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祁小乐,男,博士,研究员,硕、博士研究生导师。十三五国家重点研发计划首席科学家、全国青年岗位能手、中国农业科学院农科英才;科技部国家科技专家库专家,教育部学位中心专家,国家自然基金委同行评议专家,黑龙江省农业转基因安全委员会专家组成员;中国免疫学青年学者奖、中国畜牧兽医学会奖、黑龙江省青年科技奖、中国农业科学院建院60周年卓越奉献奖、哈尔滨兽医研究所建所70周年青年创新奖获得者。中国农业科学院哈尔滨兽医研究所禽免疫抑制病创新团队、兽医生物技术国家重点实验室、世界动物卫生组织(OIE)传染性法氏囊病参考实验室青年骨干。主要从事传染性法氏囊病(IBD)等禽免疫抑制病研究,率先提出了IBDV新的基因分型方法,首次报道了IBDV新型变异株的流行,阐明了IBDV的流行新态势;率先建立了基于RNA聚合酶II的高效IBDV反向遗传研究平台,揭示了IBDV细胞嗜性、致病和遗传变异的分子机制;合作解析了迄今分辨率最高的IBDV强、弱毒株粒子结构;创制了IBD新型疫苗,转化推广了IBD防治新技术。主持国家重点研发计划、国家自然科学基金、中法蔡元培交流合作项目、黑龙江省自然科学基金重点项目等10余项。以第一或通讯作者在Science Bulletin、Antiviral Research、Virology、Veterinary Microbiology等期刊发表论文60余篇;参编专著6部;参编国家或国际标准2项;获国家发明专利10余项;荣获黑龙江省科技进步一等奖、中华农业科技优秀创新团队一等奖、中华农业科技奖一等奖、大北农科技奖特等奖、中国专利优秀奖等成果奖6项。已培养或合作培养硕、博士研究生20余人,包括哈兽研首批博士留学生1人,学生多次获得国家奖学金等荣誉,毕业生均在重点学术机构继续深造或任职重要岗位。
[1] 国家自然科学基金面上项目:传染性法氏囊病病毒新型变异株免疫逃匿的分子机制(32072852,2021.1-2024.12),58万元,主持。
[2] 国家自然科学基金重点项目:传染性法氏囊病强、弱毒侵染宿主细胞的分子机制(31430087,2015.1-2019.12),318万元,承担(第2)。
[3] 国家自然科学基金青年基金:鸡传染性法氏囊病病毒细胞嗜性及致病性变异的分子基础(30901083,2010.1-2012.12),20万元,主持。
[4] 十三五国家重点研发计划项目:家禽主要传染病综合防控研究及国际科技合作平台建设(2016YFE0203200,2017.9-2020.8),839万元,主持。
[5] 十三五国家重点研发计划子课题:传染性法氏囊病及马立克氏病等禽免疫抑制病免疫防控新技术研究(2017YFD0500704,2017.7-2020.6),53万元,主持。
[6] 中法蔡元培交流合作项目:中国鸡传染性法氏囊病病毒基因及抗原变异的生物学意义主持(2011008007,2011.6-2013.12),17万元,主持。
[7] 中国博士后科学基金:鸡传染性法氏囊病病毒超强毒株致弱的主要分子基础(2080440921,2009.1-2011.12),3万元,主持。
[8] 黑龙江省自然科学基金重点项目:禽双RNA病毒新型变异株遗传变异及免疫逃匿的分子机制(ZD2020C006,2020.7-2023.7),50万元,主持。
[9] 黑龙江省自然科学基金青年项目:宿主蛋白CypA调控传染性法氏囊病病毒复制的分子机制(QC2015037,2015.7-2018.7),5万元,主持。
[10] 黑龙江省十四五重点研发计划:畜禽重要传染病快速诊断技术研发与推广(GA21B004,2021.9-2024.8),5万元,子课题主持。
[11] 黑龙江省十三五国家重点研发计划省级资助:家禽主要传染病综合防控研究及国际科技合作平台建设(GX18B011),67万元,主持。
[12] 黑龙江省博士后基金:鸡传染性法氏囊病病毒超强毒株致弱的主要分子基础(LBH-Z08016,2008.10-2011.12),4万元,主持。
[13] 河南省科技开放合作项目:动物重大疫病免疫防控关键技术研究(182106000048,2017.8-2019.12),8万元,子课题主持。
[14] 哈尔滨市应用技术研究与开发基金(科技攻关):传染性法氏囊病(IBD)新型疫苗技术研究(2014AB3AN058,2014.3-2017.12),120万元,主持。
[15] 哈尔滨市科技创新人才基金:鸡传染性法氏囊病新型重组疫苗的创制(2014RFQYJ129,2014.7-2016.7),6万元,主持。
主要学术奖励
[1] 鸡传染性法氏囊病变异的分子机制研究及系列疫苗研发,大北农科技奖特等奖(科技部备案),排名第2. 大北农科技有限公司.2011.
[2] 鸡传染性法氏囊病超强毒的细胞适应株及其应用,中国专利优秀奖,排名第3. 国家知识产权局.2018年.
[3] 禽重要免疫抑制病防控关键技术创制与应用,黑龙江省科技进步一等奖,排名第4. 黑龙江省政府.2018年.
[4] 鸡传染性法氏囊病超强毒变异机制及防制技术研究与应用,黑龙江省科技进步一等奖,排名第5. 黑龙江省政府.2008年.
[5] 鸡传染性法氏囊病超强毒变异机制及防制技术研究与应用,中华农业科技奖一等奖,排名第5. 农业部.2009.
[6] 新型禽用疫苗及诊断试剂研究团队,中华农业科技优秀创新团队奖一等奖,排名第6. 农业部. 2013.
[7] 禽白血病综合防控技术及应用,哈尔滨市科技进步二等奖,排名第9. 哈尔滨市政府.2016年.
主要发明专利
[1] 祁小乐,王笑梅,高玉龙,高立,李凯,崔红玉,刘长军,潘青. 一株自然适应体外细胞培养的鸡传染性法氏囊病病毒经典株及其应用,专利授权号:ZL202010090643.5.,中国,2021.8.
[2] 王笑梅,祁小乐,高玉龙,高宏雷,秦立廷,王永强,高立. 鸡传染性法氏囊病病毒重组弱毒疫苗株及其应用,专利授权号:ZL201010215328.7.,中国,2011.12.
[3] 高玉龙,王笑梅,祁小乐,王永强. 一种能够表达ALV-J囊膜蛋白的重组A亚群禽白血病病毒及其构建方法和用途,专利授权号:ZL201610574433.7.,中国,2019.10.
[4] 王笑梅,高宏雷,祁小乐,高玉龙,秦立廷,王永强.鸡传染性法氏囊病超强毒的细胞适应株及其应用, 专利授权号:ZL201210014019.2.,中国,2013.8.
[5] 王笑梅,高宏雷,祁小乐,高玉龙,秦立廷,王永强. 鸡贫血病毒VP1、VP2蛋白共表达的重组酵母工程菌、其构建方法及应用,专利授权号:ZL201110245396.2.,中国,2013.4.
[6] 王笑梅,高宏雷,祁小乐,高玉龙,秦立廷,王永强.表达禽网状内皮组织增生病病毒gp90基因的DNA疫苗及其构建方法和应用,专利授权号:ZL201210495385.4.,中国,2013.12.
[7] 王笑梅,高玉龙,李凯,祁小乐,高玉龙,王永强. 表达鸡传染性法氏囊病病毒病毒样颗粒的重组酵母菌株及其所表达的蛋白和用途,专利授权号:ZL201610161569.5.
[8] 王笑梅,高宏雷,高玉龙,祁小乐,秦立廷,王永强.表达禽网状内皮组织增生病病毒Gp90蛋白的重组酵母工程菌株、其构建方法及应用,专利授权号: ZL201110245478.7.,中国,2013.4.
[9] 王笑梅,高玉龙,秦立廷,祁小乐,王永强,高宏雷.检测禽白血病群特异性抗原的双抗体夹心ELISA试剂盒. 专利号:ZL201210113675.8.,中国,2014.8.
[10] 崔红玉,王笑梅,高宏雷,祁小乐,张艳萍,王永强. 一株乳酸片球菌菌株及其用途,专利授权号:ZL201410619374.1,中国,2017.9.
[11] 王笑梅,高宏雷,高玉龙,祁小乐,秦立廷,王永强.表达传染性法氏囊病病毒多聚蛋白基因VP243的DNA疫苗及其构建方法和应用.专利授权号:ZL201210495383.5.,中国,2015.2.
[12] 高玉龙,王笑梅,高宏雷,王永强,祁小乐,秦立廷.一种用于禽肺病毒C亚群特异性检测的荧光定量RT-PCR试剂盒及其应用.专利授权号:ZL201310014424.9.,中国,2015.3.
[13] 高玉龙,王笑梅,秦立廷,王永强,祁小乐,高宏雷.一种用于禽肺病毒A亚群特异性检测的荧光定量RT-PCR试剂盒及其应用.专利授权号:ZL201310014454.X.,中国,2014.11.
[14] 王笑梅,李凯,刘长军,张艳萍,崔红玉,祁小乐,高立,高玉龙,王永强,高宏雷. 表达传染性法氏囊病毒VP2基因的重组鸡马立克氏病病毒疫苗株及其构建方法和应用,专利授权号:ZL201600147339.3.,中国,2018.4.
[15] 王笑梅,王永强,高玉龙,高宏雷,秦立廷,祁小乐.检测A亚群禽白血病的环介导等温扩增反应引物,专利授权号:ZL201010528610.0.,中国,2012.1.
[16] 王笑梅,王永强,高玉龙,高宏雷,秦立廷,祁小乐.检测B亚群禽白血病的环介导等温扩增反应引物,专利授权号:ZL201010528615.3.,中国,2012.8.
[17] 李凯,高玉龙,王笑梅,刘长军,张艳萍,崔红玉,祁小乐,高立,王永强. 表达J亚群禽白血病病毒Gag和Env基因的重组鸡马立克氏病病毒疫苗株及其构建方法和应用,专利授权号:ZL201610147336.X.,中国,2019.12.
主要发表文章
[1] Wang YL, Fan LJ, Jiang N, Gao L, Li K, Gao YL, Liu CJ, Cui HY,Pan Q, Zhang YP, Wang XM*, Qi XL*. An improved scheme for infectious bursaldisease virus genotype classification based on both genome-segments A and B.Journal of Integrative Agriculture, 2021, 20(5): 1372–1381. (*通讯作者)
[2] Bao KY#, Qi XL#, Li Y, Gong MM, Wang XM, Zhu P. Cryo-EMstructures of infectious bursal disease virus with different virulence provideinsights on their assembly and invasion. Science Bulletin,2021. (#Contribute equally)
[3] Wang YL, Jiang N, Fan LJ, Niu XX,Zhang WY, Huang MM, Gao L, Li K, Gao YL, Liu CJ, Cui HY, Liu AJ, Pan Q, Zhang YP,Wang XM, Qi XL*. Identification and pathogenicity evaluation of a novelreassortant infectious bursal disease virus (Genotype A2dB3). Viruses, 2021, 13(9):1682.(*通讯作者)
[4] Jiang N, Wang YL, Zhang WY, Niu XX, Gao YL, Gao L, Li K, Cui HY,Liu AJ, Pan Q, Liu CJ, Zhang YP, Wang XM, Qi XL*. Naturally occurring mutatedinfectious bursal disease virus of genotype A8B1 associated with bursa damagein China. Virus Research, 2021, 302:198498. (*通讯作者)
[5] Wang Y, Jiang N, Fan LJ, GaoL, Li K, Gao YL, Niu XX, Zhang WY, Cui HY, Liu AJ, Pan Q, Liu CJ, Zhang YP, WangXM*, Qi XL*. Development of a viral‐like particlecandidate vaccine against novel variant infectious bursal disease virus.Vaccines, 2021, 9(2):142. (*通讯作者)
[6] Fan LJ, Wang YL,Jiang N, Chen MG, Gao L, Li K, Gao YL, Cui HY, Pan Q, Liu CJ, Zhang YP, Wang XM*,Qi XL*. Novel variant infectious bursaldisease virus suppresses Newcastle disease vaccination in broiler and layerchickens. Poultry Science, 2020, 99:6542-6548. (*通讯作者)
[7] Fan LJ, Wang YL,Jiang N, Gao L, Li K, Gao YL, Cui HY, Pan Q, Liu CJ, Zhang YP, Wang XM*, Qi XL*.A reassortment vaccine candidate of thenovel variant infectious bursal disease virus. Veterinary Microbiology, 2020, 251: 108905. (*通讯作者)
[8] Fan LJ, Wu TT,Wang YL, Hussain A, Jiang N, Gao L, Li K, Gao YL, Liu CJ, Cui HY, Pan Q, ZhangYP, Wang XM, Qi XL*. Novel variants of infectious bursal disease virus canseverely damage the bursa of fabricius of immunized chickens. Veterinary Microbiology, 2020, 240:108507.(*通讯作者)
[9] Wang YL, Fan LJ, Jiang N, Gao L, Li K, Gao YL, Liu CJ, Cui HY , Pan Q,Zhang YP, Wang XM, Qi XL*. Naturally occurring cell-adapted classic strain ofinfectious bursal disease virus. Veterinary Microbiology, 2020, 243: 108620. (*通讯作者)
[10]Wu TT, Wang YL, Li H, Fan LJ, Jiang N, Gao L, Li K, Gao YL, LiuCJ, Cui HY, Pan Q, Zhang YP, Wang XM*, Qi XL*. Naturally occurring homologousrecombination between novel variant infectious bursal disease virus andintermediate vaccine strain. Veterinary Microbiology, 2020, 245, 108700. (*通讯作者)
[11]Hussain A, Wu TT, Fan LJ, Wang YL, Farooq KM, Jiang N, Gao L, LiK, Gao YL, Liu CJ, Cui HY, Pan Q, Zhang YP, Asim A, Khan M, Muhammad IA, HafizMA, Wang XM*, Qi XL*. The circulation of unique reassortment strains ofinfectious bursal disease virus in Pakistan. Journal of Integrative Agriculture,2020, 19(7): 1867-1875. (*通讯作者)
[12] Fan LJ, Wu TT,Hussain A, Gao YL, Zeng XY, Wang YL, Gao L, Li K, Wang YQ, Liu CJ, Cui HY, PanQ, Zhang YP, Liu YF, He HJ, Wang XM*, Qi XL*. Novel variant strains of infectiousbursal disease virus isolated in China. Veterinary Microbiology, 2019,230:212-220. (*通讯作者)
[13] Hussain A, Wu TT, Li H, Fan LJ, Li k , Gao L, Wang YQ,Gao YL, Liu CJ, Cui HY, Pan Q, Zhang YP, Aslam A, Muti-Ur-Rehman K, Munir M,Butt SL, Wang XM*, Qi XL*. Pathogenic characterization and full length genome sequenceof a reassortant infectious bursal disease virus newly isolated in Pakistan.Virologica Sinica, 2019, 34(1):102-105. (*通讯作者)
[14] Zhang LZ, Li H, Chen YM, Gao X, Lu Z, Gao L, Wang YQ, GaoYL, Gao HL, Liu CJ, Cui HY, Zhang YP, Pan Q, Qi XL*, Wang XM*. Thedown-regulation of casein kinase 1 alpha as a host defense response againstinfectious bursal disease virus infection. Virology, 2017, 512:211-221. (*通讯作者)
[15] Chen YM, Zhang LZ, Gao L, Wang N, Lu Z, Gao X, Wang YQ,Li K, Gao YL, Cui HY, Gao HL, Liu CJ, Zhang YP, Qi XL*, Wang XM*. Ribosomalprotein L4 interacts with viral VP3 and regulates the replication of infectiousbursal disease virus. Virus Research, 2016,211:73-78.(*通讯作者)
[16] Qi XL, Gao X, Lu Z, Zhang LZ, Wang YQ, Gao L, Gao YL, LiK, Gao HL, Liu CJ, Cui HY, Zhang YP, Wang XM. A single mutation in the PBC loopof VP2 is involved in the in vitro replication of infectious bursal diseasevirus. SCIENCE CHINA Life Sciences, 2016(59): 717-723.
[17] Lu Z, Zhang LZ, Wang N, Chen YM, Gao L, Wang YQ, Gao HL,Gao YL, Li K, Qi XL*, Wang XM. Naturally occurring reassortant infectiousbursal disease virus in northern China. Virus Research. 2015, 203:92-95. (*通讯作者)
[18] Wang N. Zhang LZ, Chen YM, Lu Z, Gao L, Wang YQ, Gao YL,Gao HL, Cui HY, Li K, Liu CJ, Zhang YP, Qi XL*, Wang XM. Cyclophilin A interactswith viral VP4 and inhibits the replication of infectious bursal disease virus.BioMed Research International, 2015, 719454. (*通讯作者)
[19] Zhang LZ, Ren XG, Chen YM, Gao YL, Wang N, Lu Z, Gao L,Qin LT, Wang YQ, Gao HL, Li K, Jiang LL, Cui HY, Liu CJ, Zhang YP, Qi XL*, WangXM*. Chondroitin sulphate N-acetylgalactosaminyltransferase-2 contributes tothe replication of infectious bursal disease virus via interaction with thecapsid protein VP2. Viruses, 2015, 7(3):1474-91. (*通讯作者)
[20] Deng XY, Hu F, Qi XL*, Gao L, Li K, Gao HL, Gao YL, WangYQ, Shen N, Hua YP*, Wang XM*. Construction and characterization of therecombinant reticuloendotheliosis virus expressing enhanced green fluorescentprotein. Archive Virology, 2015, PMID: 26112763. (*通讯作者)
[21] Qi XL, Lu Z, Wang N, Chen YM, Zhang LZ, Gao L, Li K, RenXG, Wang YQ, Gao HL, Gao YL, Nicolas E, Wang XM. Analysis of the function ofD279N mutation of VP2 of infectious bursal disease virus. Journal ofIntegrative Agriculture, 2015, 14(2):2618-2625.
[22] Ren XG, Zhang LZ, Gao YL, Gao HL, Wang YQ, Liu CJ, Cui HY,Zhang YP, Jiang LL, Qi XL*, Wang XM*. Binding chicken Anx2 is beneficial forinfection with infectious bursal disease virus. Virus Resarch, 2015,210:232-240. (*通讯作者)
[23] Hu F, Zhao Y, Qi X*, Cui H, Gao Y, Gao H, Liu C, Wang Y,Zhang Y, Li K, Wang X*, Wang Y*. Soluble expression and enzymatic activityevaluation of protease from reticuloendotheliosis virus. Protein Expr Purif.2015, 114:64-70. (*通讯作者)
[24] Qi XL, Chen YM, Ren XG, Zhang LZ, Gao L, Wang N, Qin LT,Wang YQ, Gao YL, Wang XM. A reassortment vaccine candidate as the improvedformulation to induce protection against very virulent infectious bursaldisease virus. Vaccine, 2014, 32: 1436-1443.
[25] Qi XL, Zhang LZ, Chen YM, Gao L, Wu G, Qin LT, Wang YQ,Ren XG, Gao YL, Gao HL, Wang XM. Mutations of residues 249 and 256 in VP2 areinvolved in the replication and virulence of infectious bursal disease virus.Plos One, 2013, 8(7):e70982.
[26] Deng XY#, Qi XL#, Wu G, Gao YL, Qin LT, Wang YQ, Gao HL,Wang XM. Construction and characterization of the infectious clone ofReticuloendotheliosis virus carrying a genetic marker. Virus Research, 2012,167(2):146-151. (#Contribute equally)
[27] Wang YQ#, Qi XL#, Kang ZH, Yu F, Qin LT, Gao HL, Gao YL,Wang XM. A single amino acid in the C-terminus of VP3 protein influences thereplication of attenuated infectious bursal disease virus in vitro and in vivo.Antiviral Research, 2010, 87: 223-229. (#Contribute equally)
[28] Deng XY#, Qi XL#, Gao YL, Wang YQ, Qin LT, Gao HL, Gao L,Wang XM. Development of a loop-mediated isothermal amplification method forrapid detection of reticuloendotheliosis virus. Journal of Virological Methods,2010, 168: 82-86. (#Contribute equally)
[29] Qi XL, Gao HL, Gao YL, Qin LT, Wang YQ, Gao L, Wang XM.Naturally occurring mutations at residues 253 and 284 in VP2 contribute to thecell tropism and virulence of very virulent infectious bursal disease.Antiviral Research, 2009, 84: 225-233.
[30] Qi XL, Gao YL, Gao HL, Deng XY, Bu ZG, Fu CY, Wang XY,Wang XM. An improved method for infectious bursal disease virus rescue usingRNA polymerase II system. Journal of Virological Methods, 2007, 142: 81-88.
主要参编(译)著作
[1] 祁小乐 参编,《动物病毒反向遗传学》(第1版和第2版),科学出版社,2009,2014.
[2] 祁小乐 参编,《动物基因工程疫苗原理与方法》,化学工业出版社,2009.
[3] 祁小乐 参编,《兽医微生物学》(第2版)),中国农业出版社,2013.
[4] 祁小乐 参译,《兽医病毒学》(第4版),中国农业出版社,2015.
[5] 祁小乐 参译,《现代马病诊疗学》(第7版),中国农业出版社,2020.
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