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田明星,男,博士,副研究员,硕士导师,中国农业科学院上海兽医研究所畜禽细菌性传染病创新团队骨干专家。2014年8月至今,在中国农业科学院上海兽医研究所畜禽细菌性传染病创新团队工作,从事动物布鲁菌基础和应用研究,开展布鲁菌致病机制及其与宿主互作研究、布鲁菌诊断与疫苗研发工作。主持科研项目7项,其中国家自然科学基金2项,国家十三五重点研发项目子课题1项,、上海市青年科技英才扬帆计划1项,中国博士后科学基金面上一等资助1项,中央级公益性科研院所基本科研业务费专项资金项目等科研项目2项。发表文章70余篇,其中SCI收录40篇,获得授权专利4项。
1. 国家自然科学基金面上项目,32072828,LysR家族转录调控子调控流产布鲁菌毒力的分子机制研究,2021-01至2024-12,58万元,在研,主持;
2. 国家十三五重点研发项目子课题,2018YFD0500503,禽蛋生产过程中重要食源性病原微生物的流行和传播规律研究,2018.06.-2021.6,36万,完成,主持;
3. 中央科研院所科研基金,2019JB02,流产布鲁菌小编码蛋白VhpB1/2的功能研究,2019.01-2021.12,12.7万,完成,主持;
4. 国家自然科学基金青年基金项目,31602070,LsrB-like蛋白调控布鲁菌毒力的分子机制研究,2017.01-2019.12,20万,完成,主持;
5. 上海市青年科技英才扬帆计划,16YF1414600,LsrB-like蛋白调控布鲁菌毒力及抑制宿主先天免疫的机制研究,2016.06-2019.05,20万,完成,主持;
6. 中国博士后面上一等资助,2015M570184,酸休克蛋白24在布鲁菌致病机制过程中的作用机制,2015.05-2016.12,8万,完成,主持。
7. 中央科研院所科研基金,2016JB06,布鲁菌LPS隐蔽T4SS诱导巨噬细胞死亡的分子机制研,2016.01-2018.12,22万,完成,主持;
代表论文与著作
1. Zhimin Cheng, Zichen Li, YiYin, Zhengmin Lian, Hosny Ahmed Abdelgawad, Hai Hu, Xiang Guan, Dong Zuo, YumeiCai, Chan Ding, Shaohui Wang, Tao Li, Jingjing Qi, Mingxing Tian*, ShengqingYu*. Characteristics of Brucella abortus vaccine strain A19 reveals itspotential mechanism of attenuated virulence [J]. Vet Microbiol, 2021, 254,109007.
2. Mingxing Tian#, Yi Yin#, Zhengmin Lian, Zichen Li, Meiying Song, Hai Hu, XiangGuan, Chan Ding, Shaohui Wang, Tao Li, Jingjing Qi, Shengqing Yu*. A rough Brucellamutant induced macrophage death depends on secretion activity of T4SS, but noton cellular Txnip- and Caspase-2-mediated signaling pathway [J]. Vet Microbiol,2020, 244:108648.
3. MingxingTian#, Meiying Song#, Yi Yin, Zhengmin Lian, Zichen Li, Hai Hu, Xiang Guan,Yumei Cai, Chan Ding, ShaohuiWang, Tao Li, Jingjing Qi, Shengqing Yu*. Characterization of the mainimmunogenic proteins in Brucella infection for their application indiagnosis of brucellosis [J]. Comp Immunol Microbiol Infect Dis, 2020, 70:101462.
4. Mingxing Tian, Jing Qu, Peng Li, Yanqing Bao, Jiameng Liu,Chan Ding, Shaohui Wang, Tao Li, Jingjing Qi, Shengqing Yu*.Identification of novel genes essential for Brucella abortus to establishinfection by signature-tagged mutagenesis [J]. VetMicrobiol, 2019, 230:130-137.
5. Mingxing Tian#, Zhengmin Lian#, Yanqing Bao, Shijun Bao, Yi Yin, Peng Li, Chan Ding,Shaohui Wang, Tao Li, Jingjing Qi, Xiaolan Wang, Shengqing Yu*. Identificationof a novel, small, conserved hypothetical protein involved in Brucella abortus virulence by modifyingthe expression of multiple genes [J].Transbound Emerg Dis, 2019, 66(1): 349-562.
6. Mingxing Tian#, Yanqing Bao#,Peng Li, Hai Hu, Chan Ding, Shaohui Wang, Tao Li, Jingjin Qi, Xiaolan Wang,Shengqing Yu*. The putative amino acid ABC transportersubstrate-binding protein AapJ2 is necessary for Brucella virulence at the early stage of infection in a mouse model[J]. Vet Res, 2018, 49: 32.
7. Peng Li#,Mingxing Tian#, YanqingBao, Hai Hu, Jiameng Liu, Yi Yin, Chan Ding, Shaohui Wang, Shengqing Yu*. Brucella rough mutant induce macrophagedeath via activating IRE1α pathway of endoplasmic reticulum stress by enhancedT4SS secretion [J]. Front Cell Infect Microbiol, 2017, 7: 422.
8. Jianpeng Gao#, Mingxing Tian#, Yanqing Bao, Peng Li, Jiameg Liu, ChanDing, Shaohui Wang, Tao Li, Shengqing Yu*. Pyruvate kinase is necessary for Brucella abortus full virulence inBALB/c mouse [J]. Vet Res, 2016, 47(1): 87.
9. Mingxing Tian, Jing Qu, Yanqing Bao, Jiangpeng Gao, JiamengLiu, Shaohui Wang, Yingjie Sun, Chan Ding, Shengqing Yu*. Construction of pTMseries plasmids for gene expression in Brucellaspecies [J]. J Microbiol Method, 2016, 123: 18-23.
10. MingxingTian, Jing Qu,Xiangan Han, Chan Ding, Shaohui Wang, Daxin Peng, Shengqing Yu*. Mechanismof Asp24 upregulation in Brucella abortusrough mutant with a disrupted O-antigen export system and effect of Asp24 inbacterial intracellular survival [J]. InfectImmun, 2014, 82 (7): 2840-2850.
11. MingxingTian, Jing Qu,Xiangan Han, Min Zhang, Chan Ding, Jiabo Ding, Guanghua Chen, Shengqing Yu*.Microarray-based identification of differentially expressed genes inintracellular Brucella abortus withinRAW264.7 cells [J]. PLoS One, 8 (8): e67014.
专利
1. 于圣青,田明星,丁铲,韩先干,王少辉,孙英杰,瞿晶,鲍衍清,高建鹏,pTM系列质粒载体、其构建方法以及在布鲁菌表达外源基因中的应用,2019.1.11,中国:ZL201510690461.0
2. 于圣青,邹洁池,王小兰,丁铲,王少辉,韩先干,田明星,一株鸭疫里默氏杆菌脂多糖突变株及其应用,2018.4.6,中国:ZL201510030418.1
3. 于圣青,王少辉,赵益超,韩先干,丁铲,田明星,禽致病性大肠杆菌灭活疫苗及其制备方法,2017.12.12,中国:ZL201510215849.5
4. 于圣青,曹守林,韩先干,王少辉,丁铲,田明星,检测鸭MAPK1基因的荧光定量RT-PCR方法,2014.4.20,中国:ZL201310435432.0
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