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王琦,研究员,博士、博士生导师,西南重大与新发动物疫病防控科研团队首席科学家,中国农业科学院青年英才引进工程入选者,四川省杰出青年科技人才。博士毕业于中国农业科学院哈尔滨兽医研究所,师从王笑梅研究员。博士毕业后在美国华盛顿大学和北卡罗来纳大学教堂山分校进行博士后训练,从事病毒感染性疾病的免疫致病机制与免疫治疗。特别在艾滋病病毒致病机理及治疗性疫苗研制方面,取得了原创性成果。在NatureImmunology,Molecular Cell,CellHost & Microbe,Journal of Clinical Investigation,mBio,Plos Pathogens等专业期刊发表多篇SCI论文。担任Cell Host & Microbe,mBio,Journal of Virology, Aging, Frontier in Immunology,Frontier in Microbiology, Virology Journal 等期刊审稿人。主持包括国家自然科学家基金面上项目等6项省部级课题。多次在美国免疫学年会受邀做口头报告,并在波士顿获得美国逆转录病毒与机会性感染会议评选出的青年学者奖。
1. Haitao Guo*, Qi Wang*, Khader Ghneim, LiWang, Elena Rampanelli, Elizabeth Holly-Guthrie, Liang Cheng, Carolina Garrido,David Margolis, Leigh Eller, Merlin Robb, Rafick Sekaly, Xian Chen, Lishan Su,Jenny Ting. Multi-omics analyses reveal that HIV-1 alters CD4 T cellimmunometabolism to fuel virus replication. Nature Immunology,2021 Feb. https://doi.org/10.1128/NI-A29484B. (* co-first author)
2. Wei Zhang*, Qi Wang*, Fan Yang, ZixiangZhu, Yueyue Duan, Yang Yang, Weijun Cao, Keshan Zhang, Junwu Ma, Xiangtao Liu,Haixue Zheng. JMJD6 negatively regulates cytosolic RNA induced antiviralsignaling by recruiting RNF5 to promote activated IRF3 K48 ubiquitination. PlosPathogens, 2021 Feb. DOI:10.1371/journal.ppat.1009366. (* co-firstauthor)
3. Luo W, Zhang JW, Zhang W, Lin YL, Wang Q.Circulating levels of IL-2, IL-4, TNF-alpha, IFN-gamma, and Creactive proteinare not associated with severity of COVID-19 symptoms. J Med Virol. 2020Jun 10. doi: 10.1002/jmv.26156. (Corresponding Author)
4.Qi Wang, Lishan Su. Vpr enhances HIV-1 Envprocessing and virion infectivity in macrophages by modulating TET2-dependentIFITM3 expression. mBio. 2019, August, 10:e01344-19.
5. Lv, Lei*, Wang, Q*, Xu, Yanping*, Tsao, Li-chung*, Nakagawa, Tadashi, Guo,Haitao, Su, Lishan and Xiong, Yue. Vpr Targets TET2 for Degradation byCRL4VprBP E3 Ligase to Sustain IL-6 Expression and Enhance HIV-1 Replication.
Molecular Cell 70, 961–970, June 7, 2018. DOI: https://doi.org/10.1016/j.molcel.2018.05.007. (*co-firstauthor)
6.Qi Wang, Natalia Reszka-Blanco, Liang Cheng,Guangming Li, Liguo Zhang and Lishan Su. p38 MAPK is critical for nucleartranslocation of IRF-7 during CpG-induced type I IFN expression in humanplasmacytoid dendritic cells. Journal of Immunology. May 1, 2018, 200 (1 Supplement) 109.6;
7. Wang, Q., Y. Gao, Y. Wang, L. Qin, X. Qi, Y. Qu, H. Gao, and X.Wang. 2012. A 205-nucleotide deletion in the 3' untranslated region of avianleukosis virus subgroup J, currently emergen in China, contributes to its pathogenicity. J Virol 86:12849-60.
8. Wang, Q., X. Ji, Y. Gao, X. Qi, X. Wang, Y. Wang, L. Qin, andH. Gao. 2013. Overexpression of MicroRNA gga-miR-1650 Decreases the Replicationof Avian Leukosis Virus Subgroup J in Infected Cells.doi:10.1099/vir.0.054007-0.
J Gen Virol August 2013 vir.0.054007-0.
9. Wang, Q., Y. Gao, X. Ji, X. Qi, L. Qin, H. Gao, Y. Wang, and X.Wang. 2013. Differential expression of microRNAs in avian leukosis virussubgroup J-induced tumors. Vet Microbiol 162:232-8.
10. Wang, Q., X. Li, Ji, X. Y. Gao, X. Qi, L. Qin, H. Gao, Y. Wang,and X. Wang. (2014). A Recombinant Avian Leukosis Virus Subgroup J for DirectlyMonitoring Viral Infection and the Selection of Neutralizing Antibodies. PLoS One. 2014.10.1371/journal.pone.0121770
11. Ji, X*., Wang, Q*, X. Li, X. Qi, Y. Wang, H. Gao, Y. Gao, and X. Wang.(2014). A 19-nucleotide insertion
inthe leader sequence of avian leukosis virus subgroup j contributes to itsreplication in vitro but is not related to its pathogenicity in vivo. PLoSOne 9:e84797. (*co-first author)
12. Ji, X*., Wang, Q*, Y.Gao, Y. Wang, L. Qin, X. Qi, H. Gao, and X. Wang. 2013. Development of a NewDuplex Real-Time Polymerase Chain Reaction Assay for Detection of Dicer in G.gallus. J Microbiol Biotechnol 23:630-6.(*co-firstauthor)
13. Bi W, Xu W, Cheng L, Xue J, Wang Q, Yu F, XiaS, et al. IgG Fc-binding motif-conjugated HIV-1 fusion inhibitor exhibitsimproved potency and in vivo half-life: Potential application in combinationwith broad neutralizing antibodies. PLoS Pathog 2019;15:e1008082.
14. Liang Cheng, QiWang, Guangming Li, Riddhima Banga, Jianping Ma, Haisheng Yu, FumihikoYasui, Zheng Zhang, Giuseppe Pantaleo, Matthieu Perreau, Sandra Zurawski ,Gerard Zurawski, Yves Levy, Lishan Su. 2018. TLR3 agonist/CD40-targetingvaccination induces T cell response and reduces HIV-1 reservoirs. Journalof Clinical Investigation. 128, 4387-4396.
15. Guo, H. Konig, R. Deng, M. Riess, M. Mo, J.Zhang, L. Petrucelli, A. Yoh, S. M. Barefoot, B. Samo, M. Sempowski, G. D.Zhang, A. Colberg-Poley, A. M. Feng, H. Lemon, S. M. Liu, Y. Zhang, Y. Wen, H.Zhang, Z. Damania, B. Tsao, L. C. Wang,Q. Su, L. Duncan, J. A. Chanda, S. K. Ting, J. P. NLRX1 Sequesters STING toNegatively Regulate the Interferon Response, Thereby Facilitating theReplication of HIV-1 and DNA Viruses. Cell Host Microbe, 2016. 19(4): p.515-28.
16. Zhao, J. Cheng, L. Wang, H. Yu, H. Tu, B. Fu,Q. Li, G. Wang, Q. Sun, Y. Zhang, X.Liu, Z. Chen, W.Zhang, L. Su, L. Zhang, Z. (2018) Infection and depletion of CD4+ group-1 innate lymphoid cells byHIV-1 via type-I interferon pathway. PLoS Pathog 14: e1006819.
14. Chaobaihui Ye, Weiming Wang, Liang Cheng, Guangming Li,Michael Wen, Wang, Q, Qing Zhang, Dan Li, Paul Zhou and Lishan Su. Glycosyl-phosphatidylinositol (GPI)-anchored anti-HIV scFv efficientlyprotect CD4 T cells from HIV-1 infection and deletion in hu-PBL mice. J Virol 2016, doi: 10.1128/JVI.01389
17. Li, X., Zhu, H, Wang, Q., Sun, J, Wang, Y., Qi, X., Gao, H., Gao, Y., and Wang, X.Identification of a novel B-cell epitope specific for avian leukosis virus subgroupJ gp85 protein. (2015) Arch Virol. Volume 160, Issue 4, pp 995–1004
18. Li X, Wang Q, Gao Y, Qi X, Wang Y, Gao H, Gao Y, Wang X. Quantitative iTRAQ LC-MS/MSproteomics reveals the proteome profiles of DF-1 cells after infection withsubgroup J Avian leukosis virus. Biomed Res Int.2015:395307. doi: 10.1155/2015/395307. Epub 2015 Jan 8.
19. Jiang, L., X. Zeng, Y.Hua, Q. Gao, Z. Fan, H. Chai, Wang, Q.,X. Qi, Y. Wang, H. Gao, Y. Gao, and X. Wang. (2014). Genetic diversity andphylogenetic analysis of glycoprotein gp85 of avian leukosis virus subgroup Jwild-bird isolates from Northeast China. Arch Virol 159:1821-6.
20.Jiang L, Zeng X, Hua Y, Gao Q, Fan Z, Chai H, Wang Q, Qi X, Wang Y, Gao H, Gao Y,Wang X.
First isolation of reticuloendotheliosisvirus from mallards in China. ArchVirol. 2014 Jul;159(7):1821-6. doi: 10.1007/s00705-014-2004-8. Epub2014 Feb 1
21. Gao, Q., Yun, B., Wang, Q.,Jiang, L., Zhu, H., Gao, Y., Qin, L., Wang, Y., Qi, X., Gao, H., and Wang, X.(2013). Development and application of a Multiplex PCR method for the rapiddifferential diagnosis of subgroup A, B and J avian leucosis virus. JClin Microbiol. 10.1128/JCM.02200-13
22. Jiang,L., X. Qi, Y. Gao, Y. Hua, K. Li, X. Deng, Wang, Q.,L. Zhang, H. Chai, Y. Chen, C. Yin, H. Gao, L. Qin, Y. Wang, Y. Qu, Q. Chen, Z.Fan, and X. Wang. (2013). Molecular characterization and phylogenetic analysisof the reticuloendotheliosis virus isolated from wild birds in Northeast China.VetMicrobiol 166:68-75.
23. Wang, Y., Kang, Z., Gao, Y., Qin, L., Chen, L., Wang, Q., Li, J., Gao, H., Qi, X., Lin, H., and Wang, X. (2011).Development of loop-mediated isothermal amplification for rapid detection ofavian leukosis virus subgroup A.
J Virol Methods 173(1), 31-6.
24. Pan Q, Wang J,Gao Y, Wang Q, Cui H, Liu C, Qi X, et al. Identification of chicken CARhomology as a cellular receptor for the emerging highly pathogenic fowladenovirus 4 via unique binding mechanism. Emerg Microbes Infect2020;9:586-596.
25. Zhang Y, Yu Z, Lan X, Zhang F, WangQ, Li K, Pan Q, et al. A high frequency of Gallid herpesvirus-2co-infection with Reticuloendotheliosis virusis associated with high tumorrates in Chinese chicken farms. Vet Microbiol 2019;237:108418.
26. Liu A, Li H, Qi X, WangQ, Yang B, Wu T, Yan N, et al. Macrophage Migration Inhibitory FactorTriggers Inflammatory Responses During Very Virulent Infectious Bursal DiseaseVirus Infection. Front Microbiol 2019;10:2225.
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