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主要研究基于生物大数据、人工智能、序列及结构模拟等方法解析与基因高效表达以及其稳定性相关的分子特征,并对目标基因进行智能分子设计提高其应用性能。近年来主持国家自然科学基金2项,参与研究课题8项(“863”项目3项,国家自然科学基金5项)。发表研究论文39篇,其中SCI收录论文30篇,授权中国发明专利8项。
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支持扩展名:.rar .zip .doc .docx .pdf .jpg .png .jpeg2019/4-2024/3 | 生物技术研究所“青年英才计划”培育工程 |
2019/8-2022/8 | 蛋白质分子改良企业委托研究项目 |
2014/01-2017/12 | 国家自然科学基金面上项目:α-淀粉酶耐热嗜酸的分子机制及功能改造 |
[1] Meng, Xiangxi, Yang, Lixin, Liu, Hanqing, Li, Qingbin, Xu, Guoshun, Zhang, Yan, Guan, Feifei, Zhang, Yuhong, Zhang, Wei, Wu, Ningfeng* and Tian, Jian*. (2021) Protein engineering of stable IsPETase for PET plastic degradation by Premuse. Int J Biol Macromol, 180, 667-676.
[2] Yu, Xiaoxia, Zhao, Jintong, Liu, Xiaoqing, Sun, L., Tian, Jian* and Wu, Ningfeng* (2021) Cadmium Pollution Impact on the Bacterial Community Structure of Arable Soil and the Isolation of the Cadmium Resistant Bacteria. Front Microbiol, 12, 698834.
[3] Wang, Yifan, Zhang, Pingxian, Guo, Weijun, Liu, Hanqing, Li, Xiulan, Zhang, Qian, Du, Z., Hu, G., Han, Xiao, Pu, Li*, Tian, Jian*. and Gu, Xiaofeng*. (2021) A deep learning approach to automate whole-genome prediction of diverse epigenomic modifications in plants. New Phytol, 232, 880-897.
[4] Guan, Feiei#, Han, Yanshuo#, Yan, Kai, Zhang, Yan, Zhang, Zhifang, Wu, Ningfeng* and Tian, Jian* (2020) Highly efficient production of chitooligosaccharides by enzymes mined directly from the marine metagenome. Carbohydr Polym, 234, 115909.
[5] Zhang, Pingxian#, Wang, Yifan#, Chachar, S., Tian, Jian* and Gu, Xiaofeng* (2020) eRice: a refined epigenomic platform for japonica and indica rice. Plant biotechnology journal, 18, 1642-1644.
[6] Han, Yanshuo#, Guan, Feifei#, Sun, Jilu, Wu, Ningfeng* and Tian, Jian* (2020) Identification of a chitosanase from the marine metagenome and its molecular improvement based on evolution data. Appl Microbiol Biotechnol, 104, 6647-6657.
[7] Li, Qingbin#, Yan, Yaru#, Liu, Xiaoqing, Zhang, Ziding*, Tian, Jian* and Wu, Ningfeng (2020) Enhancing thermostability of a psychrophilic alpha-amylase by the structural energy optimization in the trajectories of molecular dynamics simulations. Int J Biol Macromol, 142, 624-633.
[8] Yu, Xiaoxia, Ding, Zundan, Ji, Yangyang, Zhao, Jintong, Liu, Xiaoqing, Tian, Jian*, Wu, Ningfeng* and Fan, Yunliu (2020) An operon consisting of a P-type ATPase gene and a transcriptional regulator gene responsible for cadmium resistances in Bacillus vietamensis 151-6 and Bacillus marisflavi 151-25. BMC Microbiol, 20, 18.
[9] Qin, Weitong#, Zhao, Jintong#, Yu, Xiaoxia, Liu, Xiaoqing, Chu, Xiaoyu, Tian, Jian* and Wu, Ningfeng (2019) Improving Cadmium Resistance in Escherichia coli Through Continuous Genome Evolution. Front Microbiol, 10, 278.
[10] Tian, Jian#, Li, Qingbin#, Chu, Xiaoyu and Wu, Ningfeng (2018) Presyncodon, a Web Server for Gene Design with the Evolutionary Information of the Expression Hosts. Int J Mol Sci, 19, 3872.
[11] Yu, Xiaoxia, Wei, Shuai, Yang, Yunxia, Ding, Zundan, Wang, Qian, Zhao, Jintong, Liu, Xiaoqing, Chu, Xiaoyu, Tian, Jian*, Wu, Ningfeng*, Fan, Yunliu (2018) Identification of cadmium-binding proteins from rice (Oryza sativa L.). Int J Biol Macromol, 119, 597-603.
[12] Qin, Weitong, Liu, Xiaoqing, Yu, Xiaoxia, Chu, Xiaoyu, Tian, Jian* and Wu, Ningfeng (2017) Identification of cadmium resistance and adsorption gene from Escherichia coli BL21 (DE3). RSC Advances, 7, 51460-51465.
[13] Tian, Jian, Yan, Yaru, Yue, Qingxia, Liu, Xiaoqing, Chu, Xiaoyu, Wu, Ningfeng* and Fan, Yunliu (2017) Predicting synonymous codon usage and optimizing the heterologous gene for expression in E. coli. Scientific reports, 7, 9926.
[14] Yu, Xiaoxia, Xu, Jiangtao, Liu, Xiaoqing, Chu, Xiaoyu, Wang, Ping, Tian, Jian*, Wu, Ningfeng*, Fan, Yunliu: Identification of a highly efficient stationary phase promoter in Bacillus subtilis. Scientific reports 2015, 5:18405.
[15] Tian, Jian#,Woodard, Jaie#,Whitney, Anna,Shakhnovich, Eugene(*),Thermal Stabilization of Dihydrofolate Reductaseusing Monte Carlo Unfolding Simulations and its Functional Consequences,PLoS Computational Biology, 2015, 2015, 11(4):e1004207.
[16] Tian, Jian, Wang, Ping, Huang, Lu, Chu, Xiaoyu, Wu, Ningfeng* and Fan, Yunliu (2013) Improving the thermostability of methyl parathion hydrolase from Ochrobactrum sp. M231 using a computationally aided method. Appl Microbiol Biotechnol, 97, 2997-3006.
[17] Tian, Jian, Wu, Ningfeng*, Chu, Xiaoyu, Fan, Yunliu: Predicting changes in protein thermostability brought about by single- or multi-site mutations. BMC bioinformatics 2010, 11.
[18] Tian, Jian, Wang, Ping, Gao, Shan, Chu, Xiaoyu, Wu, Ningfeng, Fan, Yunliu: Enhanced thermostability of methyl parathion hydrolase from Ochrobactrum sp. M231 by rationally engineering a glycine to proline mutation. FEBS Journal 2010, 277:4901-4908.
[19] Shi, Pengjun#, Tian, Jian#, Yuan, Tiezheng, et al: Paenibacillus sp. strain E18 bifunctional xylanase-glucanase with a single catalytic domain. Applied and environmental microbiology 2010, 76(11):3620-3624.
[20] Tian, Jian, Wu, Ningfeng*, Guo, Xuexia, Guo, Jun, Zhang, Junhua, Fan, Yunliu: Predicting the phenotypic effects of non-synonymous single nucleotide polymorphisms based on support vector machines. BMC bioinformatics 2007, 8:450.
[21] Tian, Jian, Wu, Ningfeng*, Li, Jiang, Liu, Yajie, Guo, Jun, Yao, Bin, Fan, Yunliu: Nickel-resistant determinant from Leptospirillum ferriphilum. Applied and environmental microbiology 2007, 73(7):2364-2368.
授权专利和软件著作权:(仅列出了已授权的第一发明人的专利)
[1] 一种启动子和重组表达载体及其用途和表达外源蛋白的方法(专利号:ZL201510149449.9) 2018年获国家发明专利授权。
[2] 多策略叠加提高甲基对硫磷水解酶在毕赤酵母中分泌表达量的方法(专利号:ZL201510107100.9)2017年获国家发明专利授权。
[3] 玉米组织特异性启动子及其应用(专利号:ZL201410429204.7),2017年获国家发明专利授权。
[4] 基于密码子关联分析的密码子优化系统V1.0,登记号:2016SR103338。
[5] 细胞色素结合结构域蛋白作为助分泌因子提高外源基因在毕赤酵母中分泌表达量的用途(申请号 201210469485.X),2014年获国家发明专利授权。
[6] 转植酸酶玉米的用途和制备液化液和糖化液及发酵产品的方法(申请号201210415196.1),2014年获国家发明专利授权。
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