01 宠物传染病及人兽共患病诊断制剂的研发

02 治疗性抗体、疫苗的研发

03 病原生物学、致病机制及免疫机制的基础研究

04 为企业和社会提供技术服务

1. 1. 国家自然科学基金青年基金项目：弓形虫氨基肽酶的功能解析及其作为药物靶点的可行性研究 (2012. 01- 2014. 12，23万元，主持)
2. 2. 黑龙江省自然科学基金面上项目：弓形虫甲硫氨酸氨基肽酶药物靶点的鉴定 (2015. 07 - 2018. 06，10万元，主持)
3. 3. “十三五” 国家重点研发计划项目：畜禽重要胞内寄生原虫的寄生与免疫机制研究（2017. 07- 2020. 12，95万元，子课题主持）；
4. 4. “十三五” 国家重点研发计划项目：畜禽重要人兽共患寄生虫病源头防控与阻断技术研究（2017. 07 - 2020. 12，20万元，子课题主持）；
5. 5. 国家自然科学基金面上项目：弓形虫SNARE蛋白在分泌性细胞器生物发生过程中的作用机制研究（2018. 01- 2021. 12，61万元，主持）。

1. Shinuo Cao #, Juan Yang #, Jiawen Fu #, Heming Chen, Honglin Jia. The Dissection of SNAREs Reveals Key Factors for Vesicular Trafficking to the Endosome-like Compartment and Apicoplast via the Secretory System in Toxoplasma gondii. mBio. 2021, 12(4):e0138021.doi: 10.1128/mBio.01380-21. 通讯作者
2. Pang, Y., Yamamoto, H., Sakamoto, H., Oku, M., Mutungi, J. K., Sahani, M. H., Kurikawa, Y., Kita, K., Noda, N. N. & Sakai, Y., Jia,     H*., Mizushima, N*. Evolution from covalent conjugation to non-covalent interaction in the ubiquitin-like ATG12 system. Nature structural & molecular biology, 2019, 26: 289-296, 共同通讯作者
3. Zheng, J., Su, W., Cao, S., Zhang, Z., Du, C., Jia, H*. TgMAP1c is involved in apicoplast biogenesis in Toxoplasma gondii. International Journal for Parasitology, 2020,50 :487-499, 通讯作者
4. Zhang, Z., Gu, H., Li, Q., Zheng, J., Cao, S., Weng, C., Jia, H*. GABARAPL2 Is Critical for Growth Restriction of Toxoplasma gondii in HeLa Cells Treated with Gamma Interferon. Infection and Immunity, 2020, 88: e00054-20, 通讯作者
5. Meng, X., Zheng, J., Gao, Y., Zhang, Y*. & Jia, H*. Evaluation of spore wall protein 1 as an alternative antigen for the diagnosis of Encephalitozoon cuniculi infection of farmed foxes using an enzyme-linked immunosorbent assay，Veterinary Parasitology, 2014, 203: 331-334, 通讯作者
6. Zheng, J., Jia, H*, & Zheng, Y. Knockout of leucine aminopeptidase in Toxoplasma gondii using CRISPR/Cas9. International Journal for Parasitology, 2015, 45:141-148, 通讯作者
7. Cao, S., Chen, H., Liang, X., Fu, J., Wang, S., Zheng, J., Zhang, Z., Pang, Y., Wang, J. & Shen, B., Jia, H*. The Sec1/Munc18‐like proteins TgSec1 and TgVps45 play pivotal roles in assembly of the pellicle and sub‐pellicle network in Toxoplasma gondii. Molecular microbiology, 2019, 113: 208-221, 通讯作者
8. Zheng, J., Cheng, Z., Jia, H*. & Zheng, Y. Characterization of aspartyl aminopeptidase from Toxoplasma gondii. Sci Rep, 2016, 6: 34448, 通讯作者
9. Zheng, J., Chen, Y., Li, Z., Cao, S., Zhang, Z. & Jia, H*. Translationally controlled tumor protein is required for the fast growth of Toxoplasma gondii and maintenance of its intracellular development. FASEB J, 2018, 32: 906-919, 通讯作者
10.  Li, J., Guo, H., Galon, E.M., Gao, Y., Lee, S., Liu, M., Li, Y., Ji, S., Jia, H*., Xuan，X*., Hydroxylamine and Carboxymethoxylamine Can Inhibit Toxoplasma gondii Growth through an Aspartate Aminotransferase-Independent Pathway, Antimicrob Agents Chemother, 2020, 64(3): e01889-19. 共同通讯作者
11. Ming Wang, Shinuo Cao, Nali DU, Jiawen Fu, Zhaoran Li, Honglin Jia＊, Mingxin Song*. The moving junction protein RON4, although not critical, facilitates host cell invasion and stabilizes MJ members. Parasitology. 2017, 144(11): 1490-1497
12. Mingfa Yang, Jun Zheng, Honglin Jia*, Mingxin Song*. Parasitology. 2016, 143(11):1443-9. Functional characterization of X-prolyl aminopeptidase from Toxoplasma gondii.
13. Xiangchun Meng, Jun Zheng, Xijun He, Honglin Jia*, Yanlong Zhang*. First characterization in China of Encephalitozoon cuniculi in the blue fox (Alopex lagopus). J Eukaryot Microbiol. 2014, 61(6):580-5.
14. Jia, H., Nishikawa, Y., Luo, Y., Yamagishi, J., Sugimoto, C., Xuan, X., Characterization of a leucine aminopeptidase from Toxoplasma gondii. Mol Biochem Parasitol 170, 1-6.
15. Jia, H., Zhou, J., Ikadai, H., Matsuu, A., Suzuki, H., Igarashi, I., Fujisaki, K., Xuan, X., 2006. Identification of a novel gene encoding a secreted antigen 1 of Babesia gibsoni and evaluation of its use in serodiagnosis. Am J Trop Med Hyg 75, 843-850.
16. Jia, H., Liao, M., Lee, E., Nishikawa, Y., Inokuma, H., Ikadai, H., Matsuu, A., Igarashi, I., Xuan, X., 2007. Development of an immunochromatographic test with recombinant BgSA1 for the diagnosis of Babesia gibsoni infection in dogs. Parasitol Res 100, 1381-1384.
17. Jia, H., Terkawi, M.A., Aboge, G.O., Goo, Y.K., Zhou, J., Lee, E.G., Nishikawa, Y., Igarashi, I., Fujisaki, K., Xuan, X., 2008. Babesia gibsoni: identification of an immunodominant, interspersed repeat antigen. Exp Parasitol 118, 146-149.
18. Jia, H., Aboge, G.O., Terkawi, M.A., Goo, Y.K., Nishikawa, Y., Kuriki, K., Lee, K.K., Jang, H.K., Kim, S., Fujisaki, K., Xuan, X., 2009. Genetic diversity of two selected antigen loci in Babesia gibsoni Asian genotype obtained from Japan and Jeju island of South Korea. Vet Parasitol 162, 142-146.
19. Jia, H., Terkawi, M.A., Aboge, G.O., Goo, Y.K., Luo, Y., Li, Y., Yamagishi, J., Nishikawa, Y., Igarashi, I., Sugimoto, C., Fujisaki, K., Xuan, X., 2009. Characterization of a leucine aminopeptidase of Babesia gibsoni. Parasitology 136, 945-952.
20. Jia, H., Terkawi, M.A., Aboge, G.O., Goo, Y.K., Ma, L., Zhou, J., Nishikawa, Y., Igarashi, I., Fujisaki, K., Xuan, X., 2009. Identification of secreted antigen 3 from Babesia gibsoni. Clin Vaccine Immunol 16, 944-948.