国家级项目课题

1. 国家自然科学基金面上项目“芳香烃受体AhR介导的食源和异源芳香族化合物生物学效应差异及其分子机制研究（31871891）”，2019/01-2022/12，项目主持。

2. 国家自然科学基金面上项目“食源性内分泌干扰物诱导的芳香烃受体与雌激素受体互作机理研究（31371779）”，2014/01-2017/12，项目主持。

3. 国家自然科学基金面上项目“动物产品中类固醇激素高灵敏度分析及膳食暴露评估应用基础研究（31171691）”，2012/01-2015/12，项目主持。

4. 国家自然科学基金面上项目“猪肉质相关基因转录子鉴定及功能研究（30871950）”，2009/01-2011/12，项目主持。

5.“十三五”国家重点研发课题“未知组分的核磁共振识别技术研发（2018YFC1602304）”，2018/12-2021/12，课题主持。

6. 科技部国际合作项目“中国新西兰乳品综合识别溯源技术合作研究(2015DFG31890)” ，2015/04-2018/03，项目主持。

7. “十一五”国家科技支撑计划项目“畜禽产品中潜在危害添加物识别及关键技术研究（2009BADB7B07）”，2009/01-2011/12，项目主持。

国际合作项目课题

1. IAEA技术合作项目“促进稳定同位素技术在中国优质农产品真伪识别及产地溯源中的应用（Implementing the Stable Isotope Technique for HighQuality Agro-product Traceability and Authenticity）”,CPR5022，Euro 186,380，2016-2017，项目主持。

2. 中-英伙伴框架项目BBSRC China Partnering Award“UK/China partnership for innovativetechnologies for detection of environmental pollutants in animal feed andanimal-derived food（Ref No. BB/H531435/1）”，£23,637，2010-2013，中方主持。

3. 欧盟第七框架人员交流计划项目EU Marie Curie International Staff Exchange Scheme （FP7-PEOPLE-2009-IRSES-246760），Euro86,400，2010-2013，中方主持。

1．      Dan Zhu, Biniam Kebede, Kiri McComb, AlanHayman, Gang Chen*, Russell Frew*. Milk biomarkers in relation toinherent and external factors based on metabolomics. Trends in FoodScience & Technology. 2021, 109, 51–64.

2．      Dongfei Tan, Aijin Ma, Shaolei Wang, QingyangZhang, Man Jia, Afaf Kamal-Eldin, Huaxing Wu*, and Gang Chen*. Effectsof the Oxygen Content and Light Intensity on Milk Photooxidation UsingUntargeted Metabolomic Analysis. Journal of Agricultural and FoodChemistry. 2021, 69, 26, 7488-7497.

3．      Dongfei Tan, Xia Zhang, Meicheng Su, Man Jia,Dan Zhu, Biniam Kebede, Huaxing Wu*, Gang Chen*. Establishing anuntargeted-to-MRM liquid-chromatography-mass spectrometry method fordiscriminating reconstituted milk from ultra-high temperature milk. Food Chemistry 337 (2021) 127946

4．       Jing Cui,Dan Zhu, Meicheng Su, Dongfei Tan, Xia Zhang, Man Jia, Huaxing Wu, Gang Chen*.Lipidomics Strategy for the Identification of Ultra-High Temperature andReconstituted Milk by UPLC-Q-Exactive Orbitrap Mass Spectrometry. FoodAnalytical Methods. 2021, 14(5), 1064-1073. 

5．      Xia Zhang, Min Gan, Jingyun Li, Hui Li,Meicheng Su, Dongfei Tan, Shaolei Wang, Man Jia, Liguo Zhang* and Gang Chen*.An Endogenous Indole Pyruvate Pathway for Tryptophan Metabolism Mediated by IL4I1.Journal of Agricultural and Food Chemistry, 2020, 68, 10678−10684

6．     MeichengSu, Yongyou Cheng, Congcong Zhang, Dan Zhu, Man Jia, Qingyang Zhang, Huaxing Wu,Gang Chen*. Determination of the levels of tryptophan and twelve metabolitesin milk by high-performance liquid chromatography-tandem mass spectrometry withthe QuEChERS method. Journal of Dairy Science, 2020, 103:9851-9859

7．      Min Gan, Hongbiao Ding*, Gang Chen*. 6-Formylindolo[3,2-b]carbazolereduces apoptosis induced by benzo[a]pyrene in a mitochondrial-dependent manner.Cell Biology International, 2020, DOI: 10.1002/cbin.11450

8．    JingCui, Dan Zhu, Meicheng Su, Dongfei Tan, Xia Zhang, Man Jia, Gang Chen*.  The combined use of 1H and 2D NMR-basedmetabolomics and chemometrics for non-targeted screening of biomarkers andidentification of reconstituted milk. Journal of the Science of Food and Agricultural.2019 99:6455-6461.

9．   Congcong Zhang, Jian Hu, Fengmei Sun, Man Jia,Gang Chen*, Cuiling Wu, Lufei Zheng*. Determination of four main componentsof gentamicin in animal tissues after solid phase extraction by high performanceliquid chromatography/tandem mass spectrometry. Rapid Communications inMass Spectrometry, 2018 Oct 30;32(20):1766-1772.   

10．  QiangqiangLi#, Yan Zhao#, Dan Zhu, Xiumei Pang, Yue Liu, Russell Frew, Gang Chen*.Lipidomics profiling of goat milk, soymilk and bovine milk by UPLC-Q-ExactiveOrbitrap Mass Spectrometry. Food Chemistry, 2017, 224:302-309.

11．  QiangqiangLi, Zunbo Yu, Dan Zhu, Xianghe Meng, Xiumei Pang, Yue Liu, Russell Frew, HeChen*, Gang Chen*. The application of NMR-based milk metabonomics inmilk authenticity identification. Journal of the Science of Food and Agricultural,2017, 97(9):2875-2882.

12．  Dan Zhu,Qiangqiang Li, Xiumei Pang, Xue Wang, Yue Liu, Gang Chen*. 2016. ASensitive Electrochemical Impedance Immunosensor for Determination of MalachiteGreen and Leucomalachite Green in the Aqueous Environment [J]. Analyticaland Bioanalytical Chemistry, 408(20): 5593-5600.

13．  Dan Zhu,Yang Mu, Qiangqiang Li, Xiumei Pang, Xue Wang, Yue Liu, Gang Chen*. 2016.A novel method for artificial antigen synthesis and preparation of a polyclonalantibody for the sensitive determination of leucomalachite green in fish samplesby enzyme-linked immunoassay. Analytical Method 8 (32),6236-6243.

14．  Dan Zhu,Qiangqiang Li, Kevin C. Honeychurch, Martina Piano, Gang Chen*. 2016.Determination of Malachite Green in Aquaculture Water by Adsorptive StrippingVoltammetry. Analytical Letters, 49(9): 1436-1451.

15．  Dan Zhu,Qiangqiang Li, Xiumei Pang, Yuwei Yuan, Gang Chen*.2016. Electrochemicalbehavior of isometamidium and its determination in milk samples at a SWCNT-AuNPs-modifiedglassy carbon electrode. Food Analytical Methods, 9:1963–1969.

16．  QiangqiangLi, Xianghe Meng, Dan Zhu, Xiumei Pang, Kaiqiang Wang, Russell Frew, GangChen*. Determination of Non-protein Nitrogen Adulteration in Milk by NuclearMagnetic Resonance. Analytical Letters, 2016, 49(18):1–11.

17．  XiaoxiaMi, Sicong Li, Yanhua Li, KaiqiangWang, Dan Zhu, Gang Chen*. 2014. Quantitative determination of 26 steroids in eggsfrom various species using liquid chromatography–triple quadrupole-mass spectrometry.Journalof Chromatography A. 1356: 54–63.

18．  Gang Chen, Ying Bai, Li Ren, Dan Zhu, Yanhua Li, Meiying Fang, Huda Al-Kateb,Olena Doran. 2015. Metabolism of androstenone, 17b-estradiol and dihydrotestosterone in primarycultured pig hepatocytes and the role of 3b-hydroxysteroid dehydrogenase in this process. PLOSONE Volume 10 (Issue 1) e113194.

19．  Chen Chen,Xiaoxia Mi, Yuwei Yuan, Gang Chen*,Li Ren, Kaiqiang Wang, Dan Zhu, Yongzhong Qian. 2014. A preliminary risk assessmentof potential exposure to naturally occurring estrogens from Beijing (China) marketmilk products. Food and Chemical Toxicology 71: 74–80.

20．  Yinan Du, Sicong Li, Xiaoxia Mi, Xiaochun Zheng, Gang Chen*.2014. Theelectrochemical behavior of Sudan I and Sudan II at graphene modified electrodes.AsianJ. Chem. 26(4), pp 951-954.

21．  Xiaochun Zheng, Xiaoxia Mi, Sicong Li, Gang Chen*. 2013. Determination of Xylazine and2,6-Xylidine in Animal Tissues by Liquid Chromatography - Tandem MassSpectrometry. J. Food Sci. 78(6): T955-T959.

22．   Gang Chen, Sicong Li, Xinxing Dong, Ying Bai, Ailiang Chen, ShumingYang, Meiying Fang, Galia Zamaratskaia, Olena Doran. 2012 Investigation oftestosterone, androstenone, and estradiol metabolism in HepG2 cells and primaryculture pig hepatocytes and their effects on 17βHSD7 gene expression. PLOSONE Volume 7 (Issue 12)e52255.

23．  Chen Gang, Ren, L., Yang, S.M., Qiu, J., Kamal-Eldin, A., Lundström, K.2010 Determination of androstenone levels in porcine plasma by LC-MS/MS.Food Chem. 122 1278–1282.

24．  Dong X., Bai Y., Xin Y., Xu Q., Chen Gang*, Fang M.2012 Investigationon the transcription factors of porcine 3β-hydroxysteroiddehydrogenaseand 17β-hydroxysteroid dehydrogenase genes. Gene 499:186–190.

25．  Chen Gang, Cue, R.-A., Lundstrom, K., Wood, J.D. & Doran,O. 2008. Regulation of cytochrome P450 2A6 proteinexpression by skatole, indole and testicular steroids in primary cultured pig hepatocytes. DrugMetab Dispos 36(1): 56–60.

26．  Chen Gang, Zamaratskaia, G., Andersson, H. K. & Lundström, K. 2007.Effects of raw potato starch and live weight on fat and plasma skatole, indole andandrostenone levels measured by different methods in entire male pigs. FoodChem 101, 439–448.

27．  Chen Gang, Bourneuf, E., Marklund, S., Zamaratskaia, G., Madej, A.& Lundström,   K. 2007. Gene expression of 3β-hydroxysteroiddehydrogenase and 17β-hydroxysteroid dehydrogenase in relation to androstenone,testosterone, and estrone sulphate in gonadally-intact male and castrated pigs.J Anim Sci 85, 2457–2463.

28．  Chen Gang, Zamaratskaia,G., Madej, A. & Lundström, K. 2006. Effect of hCG administration of thelevels of androstenone, skatole and indole in entire male pigs. Meat Sci72, 339–347.

第一发明人专利和软件著作权                                  

1.         鉴别复原乳和超高温灭菌乳的方法，授权号ZL201910838179.0

2.         一种鉴别超高温灭菌乳与复原乳的核磁共振波谱方法，授权号ZL201811308253.X

3.         一种鉴别奶品品质的方法，授权号ZL201510432183.9

4.         一种隐性孔雀石绿半抗原的制备方法，授权号ZL201410854438.6

5.         牛奶中雌激素的定量检测方法，授权号ZL2012 1 0028917.3

6.         牛奶中主要兽药残留核磁数据库软件V1.0，软件著作权，证书号：软著登字第6134078号。登记号：2020SR1255382

7.         食品中主要兽药残留标准品核磁数据库软件V1.0，软件著作权，证书号：软著登字第6134096号。登记号：2020SR1255400

第一完成人标准                                                  

1.         食品安全国家标准《动物性食品中赛拉嗪及代谢物2,6-二甲基苯胺残留量的测定 液相色谱-串联质谱法》。

2.         农业行业标准《饲料中赛地卡霉素的测定 液相色谱-串联质谱法》（农业部公告第316号-7-2020）。

3.         农业行业标准《饲料中他唑巴坦的测定 液相色谱-串联质谱法》（农业部公告第316号-8-2020）。

4.         农业行业标准《饲料中赛地卡霉素的测定 高效液相色谱法》（农业部2224号公告-1-2015）。