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独军政,男,博士,研究员,博士生导师,中国农业科学院兰州兽医研究所外寄生虫与虫媒疫病创新团队科研骨干,主要从事动物虫媒病毒的分子生物学、致病免疫机理、诊断技术和基因工程新型疫苗等方面的研究。近年来曾先后在丹麦科技大学国家兽医研究所、英国伦敦卫生与热带医学院和美国内布拉斯加大学病毒学中心做访问学者。主持国家级课题4项,省部级项目3项,其他项目6项,参加国家973项目、国家863计划、国家科技支撑计划、转基因生物新品种培育重大专项、国家自然科学基金等多项科研项目。在J Virol、Proteomics、Vet Microbiol、Mol Immunol、中国农业科学、畜牧兽医学报等国内外学术刊物上发表论文120余篇,其中SCI期刊收录40余篇,申请国家发明专利6项,参编《动物病毒反向遗传学》、《骆驼传染病》等专著6部,指导培养研究生10余名。
(1)国家自然科学基金面上项目:蓝舌病病毒NS1蛋白微管的形成机制与功能(31672562,2017.01-2020.12), 74.4万;
(2) 国家重点研发计划项目子课题:蓝舌病免疫增强型灭活疫苗的研制(2017YFD0502304,2017.07-2020.12), 40万;
(3)科技部国际合作项目:蓝舌病和非洲马瘟新型标记疫苗研制(CS08-L13,2015.03-2017.03),20万;
(4)甘肃省国际合作专项:蓝舌病病毒中国分离株的反向遗传学系统建立与复制缺陷型疫苗研制(1504WKCA056,2015.11-2017.11),15万元;
(5)教育部留学回国人员科研启动基金,蓝舌病病毒中国分离株反向遗传操作系统的建立(2015,2015.03-2017.03),3万;
(6)国家自然科学基金青年项目, FMDV宿主范围与整联蛋白受体的关系研究(30800833,2009.01-2011.12),20万元。
代表性论文:
Du Junzheng, Bhattacharya Bishnupriya, Ward Theresa H, et al. Trafficking of Bluetongue virus visualized by recovery of tetracysteine-tagged virion particles. J Virol. 2014, 88(21):12656-12668.
Du Junzheng, Xing Shanshan, Tian Zhancheng, et al. Proteomic analysis of sheep primary testicular cells infected with bluetongue virus. Proteomics. 2016, 16(10): 1499-1514.
Di Kang , Shandian Gao , Zhancheng Tian , Dexuan Huang , Guiquan Guan , Guangyuan Liu , Jianxun Luo , Junzheng Du* , Hong Yin*. Ovine viperin inhibits bluetongue virus replication Mol Immunol. 2020 Aug 9;126:87-94.
Du Junzheng, Gao Shandian, Tian Zhancheng, et al. Transcriptome analysis of responses to bluetongue virus infection in Aedes albopictus cells. BMC Microbiol. 2019, 10;19(1):121.
Ali Mohamed Darien K, Du Junzheng*, Gao Shandian, et al. Evaluation of immunogenicity afforded by a protein-based subunit vaccine against bluetongue virus in BALB/c mice and sheep. Vet Microbiol, 2018, 219:40-48
Du Junzheng, Gao Shandian, Tian Zhancheng, et al. MicroRNA expression profiling of primary sheep testicular cells in response to bluetongue virus infection. Infect Gen Evol. 2017,49:256-267.
Xing Shanshan, Du Junzheng*, Gao Shandian, et al. Analysis of the miRNA expression profile in an Aedes albopictus cell line in response to bluetongue virus infection. Infect Gen Evol. 2016, 39:74-84.
Du Junzheng, Guo Xinbin, Gao Shandian, et al. Induction of protection against foot-and-mouth disease virus in cell culture and transgenic suckling mice by miRNA targeting integrin αv receptor. J Biotechnol. 2014, 187:154-161.
Du Junzheng, Gao Shandian, Luo Jihuai, et al. Effective inhibition of foot-and-mouth disease virus replication in vitro by vector-delivered MicroRNAs targeting the 3D gene.Virol J. 2011, 8: 292.
Du Junzheng, Larska Magdalena, Chang Huiyun, et al. Molecular cloning and phylogenetic analysis of integrin αvβ1 and αvβ6 of one-humped camel (Camelus dromedarius). Vet Immunol Immunopath, 2010, 135: 164-171.
Du Junzheng, Chang Huiyun, Gao Shandian, et al. Molecular characterization and expression analysis of porcine integrins αvβ3, αvβ6 and αvβ8 that are potentially involved in FMDV infection. Mol Cell Probe, 2010, 24(5): 256-265.
Du Junzheng, Gao Shandian, Chang Huiyun, et al. Bactrian camel (Camelus bactrianus) integrins αvβ3 and αvβ6 as FMDV receptors: Molecular cloning, sequence analysis and comparison with other species. Vet Immunol Immunopath, 2009, 131(3-4): 190-199.
Du Junzheng, Chang Huiyun, Gao Shandian, et al. Sheep (Ovis aries) integrins αvβ1 and αvβ6 related to foot-and-mouth disease virus infection: Molecular cloning, sequence analysis and comparison with homologues. Mol Cell Probe, 2009, 23(5): 247-257.
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