1. 甘肃省科技厅，甘肃省杰出青年基金项目，17JR5RA323，天然免疫信号分子TBK1降解口蹄疫病毒蛋白VP3的机制研究，2017-09至2020-09，20万元，结题，主持。

2.  国家自然科学基金委，青年项目，31402179，口蹄疫病毒结构蛋白 VP3 调控β干扰素信号通路的分子机制，2015-01至2017-12，24万元，已结题，主持。

3. 科技部，重点研发子课题，2018YFC0840402，非洲猪瘟病毒感染、致病与免疫分子机制研究，2018-12至2021-07，100万元，在研，主持。

4. 甘肃省科技厅，重大专项子课题，20ZD7NA006-1，ASFV 致病和免疫机制研究，2020-01至2022-12, 105万元，在研，主持。

5. 家畜疫病病原生物学国家重点实验室, 自主课题, SKLVEB2020CGPY02, 非洲猪瘟免疫抑制机制研究及指导防控产品研发,2020-05至2025-05, 200万元，在研，主持。

1. 2019年甘肃省工业优秀新产品一等奖（排名第6）

2.2020年度中国农业科学院科学技术成果奖励杰出科技创新奖（排名第9）

3.2020年度中国农业科学院成功转化奖（排名第5）

4.2020-2021年度中华农业科技奖（排名第9）

5.获得一类新兽药注册证书1项（排名第6）；两个三类新兽药注册证书（排名第6和10）

一. 发表论文

1.      Li D,YangW, Li L, Li P, Ma Z, Zhang J, Qi X, Ren J, Ru Y, Niu Q, Liu Z, Liu X, Zheng H. AfricanSwine Fever Virus MGF-505-7R Negatively Regulates cGAS-STING-Mediated SignalingPathway. J Immunol. 2021;206(8):1844-1857.

2.      Li D, LiuY, Qi X, Wen Y, Li P, Ma Z, Liu Y, Zheng H, Liu Z. AfricanSwine Fever Virus MGF-110-9L-deficient Mutant Has Attenuated Virulence in Pigs. VirolSin. 2021;36(2):187-195.

3.      Yang W#, Li D#, Ru Y, Bai J, Ren J, Zhang J, Li L, Liu X, ZhengH. Foot-and-Mouth Disease Virus 3A ProteinCauses Upregulation of Autophagy-Related Protein LRRC25 To Inhibit theG3BP1-Mediated RIG-Like Helicase-Signaling Pathway. JVirol. 2020;94(8):e02086-19.

4.      Li D, YangW, Ren J, Ru Y, Zhang K, Fu S, Liu X, Zheng H. TheE3 Ubiquitin Ligase TBK1 Mediates the Degradation of Multiple Picornavirus VP3Proteins by Phosphorylation and Ubiquitination. JVirol. 2019;93(23):e01438-19.

5.      Li D, YangW, Ru Y, Ren J, Liu X, Zheng H. Thioredoxin2 Negatively Regulates Innate Immunity to RNA Viruses by Disrupting theAssembly of the Virus-Induced Signaling Adaptor Complex. JVirol. 2020;94(7):e01756-19.

6.      Li D,LiS, Sun Y, Dong H, Li Y, Zhao B, Guo D, Weng C, Qiu HJ. Poly(C)-bindingprotein 1, a novel N(pro)-interacting protein involved in classical swine fevervirus growth. J Virol. 2013;87(4):2072-80.

7.      Li D, DongH, Li S, Munir M, Chen J, Luo Y, Sun Y, Liu L, Qiu HJ. Hemoglobinsubunit beta interacts with the capsid protein and antagonizes the growth ofclassical swine fever virus. J Virol.2013;87(10):5707-17.

8.      Li D,YangW, Yang F, Liu H, Zhu Z, Lian K, Lei C, Li S, Liu X, Zheng H, Shu H. TheVP3 structural protein of foot-and-mouth disease virus inhibits the IFN-βsignaling pathway. FASEB J. 2016;30(5):1757-66.

9.      Li D, FuS, Wu Z, Yang W, Ru Y, Shu H, Liu X, Zheng H. DDX56inhibits type I interferon by disrupting assembly of IRF3-IPO5 to inhibit IRF3nucleus import. J Cell Sci. 2019;133(5):jcs230409.

10. Yi J, Peng J, Yang W, Zhu G, Ren J, Li D*, Zheng H*. Picornavirus3C - a protease ensuring virus replication and subverting host responses. JCell Sci. 2021;134(5):jcs253237.

11.  Li D, Zhang J, YangW, He Y, Ru Y, Fu S, Li L, Liu X, Zheng H. Poly(rC) binding protein 2 interacts with VP0 and increases the replication of thefoot-and-mouth disease virus. Cell Death Dis. 2019;10(7):516.

12.  YangW, Ru Y, Ren J, Bai J, Wei J, Fu S, Liu X, LiD*, Zheng H*.G3BP1inhibits RNA virus replication by positively regulating RIG-I-mediated cellularantiviral response. Cell Death Dis.2019;10(12):946.

13.  PengJ, Yi J, Yang W, Ren J, Wen Y, Zheng H*,Li D*.Advances inFoot-and-Mouth Disease Virus Proteins Regulating Host Innate Immunity. FrontMicrobiol. 2020;11:2046.

14.  Li D, Wei J, Yang F,Liu HN, Zhu ZX, Cao WJ, Li S, Liu XT, Zheng HX, Shu HB.Foot-and-mouthdisease virus structural protein VP3 degrades Janus kinase 1 to inhibit IFN-γsignal transduction pathways. Cell Cycle.2016;15(6):850-60.

15.  FuSZ, Yang WP, Ru Y, Zhang KS, Wang Y, Liu XT, Li D*, Zheng HX*. DDX56 cooperates with FMDV3A to enhance FMDV replication by inhibiting the phosphorylation of IRF3. CellSignal. 2019;64:109393.

16.  Li D, Wu PX, Liu HN,Feng T, Yang WP, Ru Y, Li P, Qi XL, Shi ZW, Zheng HX. A QP509L/QP383R-deletedAfrican swine fever virus is highly attenuated in swine but does not conferprotection against parental virus challenge. J Virol. 2021; JVI0150021. doi:10.1128/JVI.01500-21.

17.  Li D, Zhang J, Yang WP, Li P, Ru Y, LiLL, Ran Y, Zheng HX. African swine fever virus protein MGF-505-7R promotesvirulence and pathogenesis by inhibiting JAK1- and JAK2-mediated signaling. JBiol Chem. 2021; 297(5):101190. doi: 10.1016/j.jbc.2021.101190.

18.  ZhangJ#, Li D#, YangWP, Li LL, Zheng HX. Foot-and-mouthdisease virus VP3 protein acts as a critical proinflammatory factor bypromoting toll-like receptor 4-mediated signaling. J Virol. 2021:JVI0112021.doi: 10.1128/JVI.01120-21.

19. Kang WF, Wang Y, Yang WP, Zhang J, ZhengHX, Li D. Researchprogress on the structure and function of G3BP. FrontImmunol. 2021; 12:718548. doi: 10.3389/fimmu.2021.718548.

20. Wang Y, Kang W, Yang W, Zhang J, Li D*, Zheng H*. Structureof African swine fever virus and associated molecular mechanisms underlying infectionand immunosuppression: A Review. FrontImmunol. 2021;12:715582. doi: 10.3389/fimmu.2021.715582.

二. 授权专利

1.      郑海学，李丹，杨文萍，任静静，茹毅，郝荣增，张克山，田宏，杨帆，刘湘涛。TBK1作为E3泛素连接酶的应用: ZL201910401904.8[P].2019-08-16.

2.      郑海学，李丹，杨文萍，张敬，茹毅，郝荣增，张克山，田宏，曹伟军，刘湘涛。MG132作为疫苗生产增效剂及稳定剂的用: ZL201910399786.1[P]. 2019-08-06.

3.      郑海学，李丹，张敬，杨文萍，李露露，茹毅，田宏，张克山，杨帆，刘湘涛。敲低TLR4基因猪肺泡巨噬细胞系的构建方法及其应用: ZL201910871910.X[P]. 2019-09-16.

4.      郑海学，李丹，李露露，杨文萍，张敬，茹毅，彭江玲，张克山，田宏，杨帆，刘湘涛。口蹄疫病毒3D蛋白作为细胞TLR3通路激活剂的应用：ZL201910839428.8[P].2019-09-16.

5.      郑海学，李丹，赵要风，刘恬然，彭高闯，杨帆，田宏，冯涛，齐晓兰，杜旭光，张克山，郭建宏，吴森。一种TOB1基因敲除单克隆细胞系的构建方法和应用：ZL202010522276.1[P].2020-05-22.

6.      郑海学，李丹，李攀，齐晓兰，张克山，茹毅，杨吉飞，田宏，杨帆，申超超，刘志杰，吴森，党文，殷宏，刘湘涛。一种天然免疫抑制基因缺失的减毒非洲猪瘟病毒株及应用：ZL202010233449.8[P].2020-03-29.