团队主要以动物虫媒与虫媒病为研究对象，紧跟国际科技前沿和国家重大需求，围绕“外寄生虫与虫媒疫病病原生物学和流行病学”与“外寄生虫与虫媒疫病防控技术”两个研究方向，主要开展如下7个方面的研究工作。

　　1. 外寄生虫生物学：开展资源库建设、新虫媒发现与鉴定、虫媒生物系统进化及发育调控与传播病原的分子机制等方面的研究。

　　2. 虫媒与虫媒疫病病原生态学：开展病原分类与遗传演化、病原生态与流行动态和分子流行病学监测技术等研究。

　　3. 外寄生虫及虫媒病原功能基因及组学：开展重要虫媒与虫媒病病原组学数据的测定与分析、功能基因挖掘及其功能解析等研究。

　　4．病原-宿主-媒介互作机制：开展病原与媒介及脊椎动物与病原和媒介间互作的分子机制的研究。

　　5. 外寄生虫与虫媒病防控技术：研发外寄生虫和虫媒病绿色长效防控制剂、生物防治制剂及综合控制技术。

　　6. 虫媒病诊断检测技术：研发敏感特异、简单快速、高通量的虫媒病检测方法和制剂。

　　7. 外寄生虫和虫媒病疫苗：研制虫媒和虫媒病新型疫苗，开发脂多糖、干扰素、细胞因子、免疫核酸等免疫佐剂和分子佐剂。

（1）国家自然科学基金委员会，面上项目，32072830，基于表观遗传因子BRD4调控非

　　洲猪瘟病毒复制的分子机制研究，2021.01-2024.12，58万元，主持；

（2）甘肃省科学技术厅，甘肃省重大专项，20ZD7NA006，非洲猪瘟流行病学，致病与免

　　疫机制及疫苗开发，2021.01-2023.12，300万，主持；

（3）中国农业科学院兰州兽医研究所，家畜疫病病原生物学国家重点实验室自主课题，重大成果培育项目，SKLVEB2020CGPY02，非洲猪瘟免疫抑制机制研究及指导防控产品研发，2020.01-2024.12，90万，主持；

（4）中国农业科学院兰州兽医研究所，基本科研业务费，1610312021002，ATM/ATR/DNA-

　　PK信号通路调控非洲猪瘟病毒复制的分子机制研究，2021.01-2023.12，30万，主持；

（5）国家自然科学基金委员会，青年基金项目，31502054，青海血蜱水通道蛋白（AQPs）基因亚型鉴定与生物学功能分析，2016.01-2018.12，24万，主持；

（6）中国农业科学院，基本科研业务费预算增量项目，2015ZL009，新疆巴贝斯虫未定种棒状体相关蛋白免疫功能初步分析，2015.01-2015.12，20万元，主持；

（7）甘肃省科学技术厅，甘肃省青年科技基金，1007RJYA002，一种新发人兽共患传染病-莱姆病检测与危险评估，2010.01-2012.12，2万元，主持；

（8）中国-欧盟科技合作项目EC project PIROVAC,KBBE-3-245145,新疆巴贝斯虫未定种棒状体相关蛋白研究，500万元，参加；

（9）国家自然科学基金委员会，青年基金项目，31101621，硬蜱部分争议种分类地位的研究，2012.01-2014.12，24万元，参加；

（10）国家自然科学基金委员会，面上项目，30972182，动物梨形虫条形码基因的挖掘与DNA分类工具的建立，2010.01-2012.12，30万元，参加.

发表论文：

1.       Niu Q, Hu H, et al. Structure-guided drugdesign identifies a BRD4-selective small molecule that suppresses HIV. J Clin Invest, 2019;129(8):3361-3373. IF: 12.282

2.       Auclair S, Liu F, Niu Q, Hou W, Churchyard G et al.Distinct susceptibility of HIV vaccine vector-induced CD4 T cells to HIVinfection. PloS Pathog, 2018; 14:e1006888. IF: 6.158

3.       Liu F, Niu Q, Fan X, Liu C,Zhang J,WeiZ et al. Priming and Activation of Inflammasome by Canarypox Virus Vector ALVACvia the cGAS/IFI16-STING-Type I IFN Pathway and AIM2 Sensor. J Immunol, 2017; 199: 3293-3305. IF: 4.539

4.       NiuQ, Yang J, Liu Z, Gao S, Pan Y, Guan G,et al. First moleculardetection of piroplasm infection in pet dogs from Gansu, China. FrontMicrobiol, 2017; 8:1029. IF: 4.019

5.       NiuQ, Liu Z, Yang J, Gao S, Pan Y, Guan G,et al. Genetic characterization and molecular survey of Babesia sp. Xinjianginfection in small ruminants and ixodid ticks in China. Infect Genet Evol.2017; 49: 330-335. IF: 2.88

6.       NiuQ, Guan G, Liu Z, Yang J, Yu P, Pan Y, etal. Molecular cloning, characterization and antigenicity of Babesia sp. BQ1(Lintan) (Babesia cf. motasi) apical membrane antigen-1 (AMA-1). Parasitology, 2017; 144(5):641-649. IF: 2.511

7.       NiuQ, Liu Z, Yang J, Yu P, Pan Y, Zhai B, etal. Expression analysis and biological characterization of Babesia sp. BQ1(Lintan) (Babesia motasi-like) rhoptry-associated protein 1 and its potentialuse in serodiagnosis via ELISA. Parasit & Vectors, 2016; 9:313. IF: 3.234

8.       NiuQ, Liu Z, Yang J, Yu P, Pan Y, Zhai B, etal. Genetic diversity and molecular characterization of Babesia motasi-like insmall ruminants and ixodid ticks from China. Infect Genet Evol,2016; 41:8-15. IF: 2.591

9.       NiuQ, Liu Z, Yang J, Yu P, Pan Y, Zhai B, etal. Expressionof sheep pathogen Babesia sp. Xinjiang rhoptry associated protein 1 andevaluation of its diagnostic potential by enzyme-linked immunosorbent assay.Parasitology, 2016, 143:1990-1999. IF: 3.031

10.     Niu Q,Bonsergent C, Rogniaux H, Guan G, Malandrin L, Moreau E. RAP-1a is the mainrhoptry-associated-protein-1 (RAP-1) recognized during infection with Babesiasp. BQ1 (Lintan) (B. motasi-like phylogenetic group), a pathogen of sheep inChina. Vet Parasitol, 2016,232:48-57. IF: 2.545

11.     Yu P*, Niu Q*, Liu Z, Yang J, Chen Z, Guan G,et al. Using molecular epidemiological surveillance to assess the emergenceand re-emergence of tick-borneinfections in China. Acta Trop, 2016, 158: 181-188. IF: 2.38

12.     OmarAbdallah M*, Niu Q*, Yu P, Guan G, Yang J, Chen Z,et al. Identification of piroplasm infection by RLB in questing tick species ofChina: A broad range extension of tick-borne piroplasm in China? Parasitol Res, 2016,115: 2035-2044. IF:2.558

13.     Niu Q, Liu Z, Yu P, Yang J, Omar Abdallah M, Guan G, et al. Geneticcharacterization and molecular survey of Babesia bovis, Babesia bigemina andBabesia ovata in cattle, dairy cattle and yaks in China. Parasit & Vectors,2015, 8:518. IF: 3.43

14.     Niu Q, Marchand J, Yang C, Bonsergent C, Guan G, Yin H, Malandrin L. Rhoptry-associatedprotein (rap-1) genes in the sheep pathogen Babesia sp. Xinjiang: Multipletranscribed copies differing by 3’ end repeated sequences. VetParasitol, 2015, 211: 158-69. IF:2.46

15.     Niu Q, Valentin C, Bonsergent C, Malandrin L. Strongconservation of rhoptry-associated-protein-1 (RAP-1) locus organization andsequence among Babesia isolates infecting sheep from China (Babesia motasi-likephylogenetic group). Inf Gen Evol, 2014, 28: 21-32. IF: 3.015

16.     Niu Q,Bonsergent C, Guan G, Yin H, Malandrin L. Sequence and organization of therhoptry-associated-protein-1 (rap-1) locus for the sheep hemoprotozoan Babesiasp. BQ1 Lintan (B. motasi phylogenetic group). Vet Parasitol, 2013, 198: 24-38. IF: 2.545

17.    Niu Q, GuanG, Liu Z, Ma M, Li Y, Liu A, et al. Simultaneous detection of piroplasmainfections in field Haemaphysalis qinghaiensis ticks by reverse line blotting.Exp Appl Acarol, 2012, 56:123-32. IF 1.847

18.     Niu Q,Luo J, Guan G, Liu Z, Ma M, Liu A, et al. Differentiation of two ovine Babesiabased on the ribosomal DNA internal transcribed spacer (ITS) sequences. ExpParasitol , 2009, 121: 64-8. IF: 1.773

19.     Niu Q,Luo J, Guan G, Ma M, Liu Z, Liu A, et al. Detection and differentiation ofovine Theileria and Babesia by reverse line blotting in China, Parasitol Res, 2009, 104:1417-23. IF:1.721

20.     GuanG, Niu Q, Yang J, Li Y, Gao J, LuoJ, et al. Trypanosoma (Herpetosoma) grosi: first isolation from Chinese stripedfield mouse (Apodemus agrarius). Parasitol Int,2011, 60:101-4. IF:2.055

21.     AbdallahMO, Niu Q, Yang J, Hassan MA, Yu P , Guan G, et al.Identification of 12 Piroplasms Infecting Ten TickSpecies in China Using Reverse Line Blot Hybridization.JParasitol, 2017, 103: 221-227. IF: 1.395

22.     YangJ, Liu Z, Niu Q, Mukhtar MU, Guan G,et al. A novel genotype of "Anaplasma capra" in wildlife and itsphylogenetic relationship with the human genotypes. Emerg Microbes Infect,2018, 7:210. IF: 6.032

23.     HanR, Yang J, Niu Q, Liu Z, Chen Z, etal. Molecular prevalence of spotted fever group rickettsiae in ticks fromQinghai Province, northwestern China. InfectGenet Evol, 2018, 57:1-7. IF: 2.545

24.     YangJ, Han R, Niu Q, Liu Z, Guan G, etal. Occurrence of four Anaplasma species with veterinary and public healthsignificance in sheep, northwestern China. Ticks Tick Borne Dis,2018, 9:82-85. IF:2.612

25.     YuP, Liu Z, Niu Q, Yang J, Abdallah MO,et al. Molecular evidence of tick-borne pathogens in Hyalomma anatolicum ticksinfesting cattle in Xinjiang Uygur Autonomous Region, Northwestern China. ExpAppl Acarol. 2017,73:269-281. IF:1.929

26.     YangJ, Liu Z, Niu Q, Liu J, Han R, etal. A novel zoonotic Anaplasma species is prevalent in small ruminants:potential public health implications. Parasit Vectors,2017, 10:264. IF: 3.163

27.     WangZ, Yang J, Niu Q, Brayton KA, Luo J,et al. Identification of Anaplasma ovis appendage-associated protein (AAAP) fordevelopment of an indirect ELISA and its application. Parasit Vectors,2017, 10:359. IF: 3.163

28.     YangJ, Liu Z, Niu Q, Luo J, Wang X, etal. Molecular Detection of Anaplasma phagocytophilum in Wild Cervids and Haresin China. JWildl Dis, 2017, 53:420-423. IF: 1.247

29.     YangJ, Guan G, Niu Q, Liu Z,Li Y,Liu J,et al. Development and application of a loop-mediated isothermal amplificationassay for rapid detection of Borreliaburgdorferi s. l. in ticks, 2013, 60: 238-44. IF:3.504

30.     AlamerE, Zhong C, Liu Z, Niu Q, Long F, etal. Epigenetic Suppression of HIV in Myeloid Cells by the BRD4-Selective SmallMolecule Modulator ZL0580. J Virol, 2020, 94:e01880-19.IF: 4.501

31.     IqbalN, Mukhtar MU, Yang J, Niu Q, Li Z,et al. Identification and evaluation of midgut protein RL12 of Dermacentorsilvarum interacting with Anaplasma ovis VirD4. Ticks Tick Borne Dis, 2021, 12:101677. IF: 3.744

授权专利：

1.       牛庆丽，杨吉飞，赵亚茹，刘志杰，关贵全，罗建勋，殷宏，化合物ARV-825用于制备预防或治疗非洲猪瘟药物的新用途。2021.06.08，中国，ZL202010684043.1

2.       牛庆丽，杨吉飞，赵亚茹，刘志杰，关贵全，罗建勋，殷宏，化合物I-BET-762用于制备预防或治疗非洲猪瘟药物的新用途。2021.06.08，中国，ZL202010684033.8

3.       牛庆丽，杨吉飞，赵亚茹，刘志杰，关贵全，罗建勋，殷宏，化合物PLX51107用于制备预防或治疗非洲猪瘟药物的新用途。2021.06.08，中国，ZL202010684339.3

4.       牛庆丽，杨吉飞，赵亚茹，刘志杰，关贵全，罗建勋，殷宏，化合物ZL0580用于制备预防或治疗非洲猪瘟药物的新用途。2021.06.08，中国，ZL202010684287.X

5.       牛庆丽，刘志杰，杨吉飞，潘玉萍，关贵全，罗建勋，殷宏，羊新疆巴贝斯虫未定种的诊断试剂盒及检测方法。2020.02.18，中国，ZL201610905860.9

6.       牛庆丽，刘志杰，杨吉飞，关贵全，李有全，殷宏，罗建勋，一种用于羊新疆巴贝斯虫病检测的间接ELISA方法。2018.10.16，中国，ZL201610890348.1

7.       刘志杰，赵亚茹，杨吉飞，牛庆丽，刘光远，罗建勋，关贵全，殷宏，抗非洲猪瘟病毒P30蛋白单域抗体和检测非洲猪瘟病毒的ELISA试剂盒。2021.03.30，中国，ZL201910972470.7

8.       刘爱红，关贵全，刘军龙，谢俊仁，牛庆丽，罗建勋，殷宏, 一种检测羊巴贝斯虫的实时荧光定量PCR试剂盒。 2017.10.31, 中国，ZL201510011313.1.