国家重点实验室自主研究课题：甲病毒感染小鼠动物模型的建立及其致病性研究，(SKLVBP2018002，2021.01-2021.12)，10万元

企业横向课题：BHK-1025细胞个性化无血清培养基产品升级的测试评价服务，(2020.11-2025.10)，260万元

国家自然科学基金青年项目：口蹄疫病毒基因组3'非编码区通过DDX21诱导I型干扰素产生的分子机制，(31400138，2015.01-2017.12)，23万元

中央级公益性科研院所基本科研业务费：通过药物筛选聚合酶高保真性突变体获取口蹄疫病毒减毒株，(1610302014017，2014.01-2014.12)，13万元

中央级公益性科研院所基本科研业务费：O型、A型和Asia1型口蹄疫病毒耐酸毒株的筛选，(0302013012，2013.01-2013.12)，15万元

国家重点研发计划：种畜场口蹄疫净化技术集成与示范，(2016YFD0501505，2016.07-2020.12)，80万元

国家自然科学基金面上项目：内部核糖体进入位点决定口蹄疫病毒毒力的分子机制，(31770173，2018.01-2021.12)，55万元

代表论文与著作

Yang Decheng#,Sun Chao#, Gao Rongyuan, Wang Haiwei, Liu Wenming, Yu Kewei, Zhou Guohui, ZhaoBo, Yu Li*. A Temperature-Dependent Translation Defect Caused by IRES MutationAttenuates Foot-And-Mouth Disease Virus: Implications for Rational VaccineDesign. J Virol. 2020 Jun 3: JVI.00990-20.doi: 10.1128/JVI.00990-20.

LiuWenming#, Yang Decheng#, SunChao, Wang Haiwei, Zhao Bo, Zhou Guohui, Yu Li*. hnRNP K Is a Novel ITAF ThatNegatively Regulates Foot-And-Mouth Disease Virus Translation and Replicationand Is Antagonized by Viral 3C Protease. JVirol. 2020 Jun 24: JVI.00803-20. doi: 10.1128/JVI.00803-20. 

SunChao, Liu Mengmeng, Chang Jitao, YangDecheng*, Zhao Bo, Wang Haiwei, Zhou Guohui, Weng Changjiang, Yu Li*. hnRNPL negatively regulates foot-and-mouth disease virus replication throughinhibiting viral RNA synthesis by interacting with IRES in 5' untranslatedregion. J Virol. 2020 May 4; 94(10):e00282-20. doi: 10.1128/JVI.00282-20. 

ChaoSun#, Decheng Yang#, Rongyuan Gao,Te Liang, Haiwei Wang, Guohui Zhou and Li Yu* Modification of the InternalRibosome Entry Site Element Impairs the Growth of Foot-and-Mouth Disease Virusin Porcine-derived Cells J Gen Virol, 2016, 97: 901-11.

Te Liang#, Decheng Yang#, Mengmeng Liu, Chao Sun, Fang Wang, Jingfei Wang, HaiweiWang, Shanshan Song, Guohui Zhou, Li Yu* Selection and characterization of anacid-resistant mutant of serotype O foot-and-mouth disease virus. Arch Virol, 2014, 159(4):657-67.

Decheng Yang,Chunyuan Zhang, Lei Zhao, Guohui Zhou, Haiwei Wang, Li Yu* Identification of aconserved linear epitope on the VP1 protein of serotype O foot-and-mouthdisease virus by neutralising monoclonal antibody 8E8. Virus Research, 2011, 155: 291–299.

专利和标准

于力，杨德成，王海伟，周国辉，孙超，耐热表型稳定遗传、携带负标记的重组口蹄疫病毒无毒株及O/A型口蹄疫二价灭活疫苗，202010780070.9

于力，杨德成，梁争论，毛群颖，表达人肠道病毒71型衣壳蛋白的重组腺病毒、由其制备的疫苗和应用，ZL201510391127.5

于力，杨德成，王海伟，周国辉，口蹄疫病毒温度敏感减毒株及其构建方法和用途，ZL201711093774.3

于力，杨德成，O型口蹄疫病毒耐酸突变株、其携带的衣壳蛋白及其编码基因和应用，ZL201210499507.7

于力，杨德成，于永忠，周国辉，O型口蹄疫病毒变异株及其编码基因和应用，ZL201010160669.9

Li Yu，DechengYang，Haiwei Wang，Guohui Zhou，Temperature-sensitiveattenuating strain of Foot-and-mouth disease virus, construction methodtherefor and uses thereof, PCT/CN2017/111936, WO2018/090994A1

LiYu，DechengYang，Haiwei Wang，Guohui Zhou，ChaoSun, Recombinant avirulent strains of foot-and-mouth disease virus possessingnegative markers and thermostability phenotype and O/A type bivalentinactivated vaccine, PCT/CN2020/111715

于力，周国辉，杨德成，表达O型口蹄疫病毒空衣壳的重组缺损腺病毒及其应用，ZL201210030115.6

于力，王海伟，杨德成，周国辉，Asia1型口蹄疫病毒感染性cDNA 及其构建方法和应用，ZL200810171258.2

于力，周国辉，杨德成，表达O型口蹄疫病毒空衣壳的重组缺损腺病毒及其构建方法和应用，ZL2014100587130.X