1. 十三五重点研发：DTMUV传播与致病机理研究 子课题 2016.7-2021.6 130 万元 子课题负责人 主持

2. 国家自然科学基金面上项目：DTMUV分子致弱机理研究 2017.1-2020.12 75万元 项目主持人

3. 农科院协同创新：肉鸭重要病毒病诊断技术研究 课题 70万元 主持人

4. 国家自然科学基金面上项目：p10.8核质转运机理研究 2011.1-2013.12 35万元 项目主持人

5.现代农业产业技术水禽病岗位科学家专项：鹅病岗位科学家专项2011-2013 210万元 项目主持人

6. 农业行业水禽专项：水禽病诊断技术 2010.1-2014.12 80万元 主持人

7. 973项目：新发传染病-番鸭呼肠孤病毒的分子生物学特性研究 2005.1-2009.12 80万元 子课题主持人

8. 农科院科技经费项目：p10.8蛋白结构功能研究 CAAS-KJJF-2009.1-12 10万元 主持

9.黑龙江省博士后基金：HLJSBSH-06 2006.1-2007.12 5万元 主持

获奖：

1. H5N3 流感病毒细胞分子标记灭活疫苗研究-获黑龙江省科技进步二等奖（ 第三 名）；

2. H5N3流感病毒细胞培养灭活疫苗和禽流感分子标记疫苗研究-获哈尔滨市科技进步一等奖（ 第三名）；

3. 水禽呼肠孤和细小病毒病诊断技术-获中国农业科学院科技进步二等奖（ 第一 名）；

4. 水禽呼肠孤和细小病毒诊断技术-获哈尔滨市科技进步一等奖（ 第一 名）。

发表SCI论文：

1. Xueming Chen, Chenxi Li, Weiwei Lin, Tongtong Li, Xiaofei Bai X, Shaozhou Wulin,Qinghshan Zhang,Shuang Li, Ming Liu, Jyung-Hurng Liu, Yun Zhang * . A Novel Neutralizing Antibody Targeting a UniqueCross-Reactive Epitope on the hi Loop of Domain II of the Envelope Protein Protects Mice against DuckTembusu Virus. 2020, The Journal of Immunology. doi:10.4049/jimmunol.1901352.

2. Xueming Chen, Tongtong Li, Xiaodan Chen, Li C, Weiwei Lin, Hongyu Liu, Shuping Song, Xiaofei Bai, YunZhang *. Characterization of Monoclonal Antibodies against_A Protein and Cross-Reactive EpitopeIdentification and Application for Detection of Duck and Chicken Reovirus Infections. Pathogens 2019, 8, 140.

3. Xueming Chen, Yuhuan Chen, Chunguo Liu, Xiaojun Li, Hongyu Liu, Xiuchen Yin, Xiaofei Bai, Ming Ge,Ming Liu, Yuanzhao Du, Chengguo Fan, Yun Zhang * 。Improved one-tube RT-PCR method for simultaneousdetection and genotyping of duck hepatitis A virus subtypes 1 and 3. PLoS ONE. 2019. 14(8): e0219750.

4. Qingshan Zhang, Chunhe Wan, Chenxi Li, Xiaofei Bai, Ming Liu, Shiguo Liu, Yun Zhang*. Evaluation of aquantitative real-time PCR for rapid detection of Riemerella Anatipestifer infection in birds. J Vet Med Sci 2017.79(12):2057-2062.

5. Yun Liu, Hongtao Li, Yujia Xue, Shuangshuang Zhao, Chenxi Li, Liandong Qu, Yun Zhang*, Liu M.Characterization of Monoclonal Antibodies against HA Protein of H1N1 Swine Influenza Virus and ProtectiveEfficacy against H1 Viruses in Mice. Viruses. 2017.9, 209.

6. Chenxi Li, Junyan Liu, Wulin Shaozhou, Xiaofei Bai, Qingshan Zhang, Ronghong Hua, Jyung-Hurng Liu,Ming Liu, Yun Zhang * . Epitope Identification and Application for Diagnosis of Duck Tembusu Virus Infectionsin Ducks. Viruses. 2016, 8, 306;

7. Xiaoying Wu, Tingting Zhang, Fanyi Meng, Dongchun Guo, Xiuchen Yin, Wulin Shaozhou, Chenxi Li,Qingshan Zhang, Ming Liu, Yun Zhang * . Mapping a Type-specific Epitope by Monoclonal Antibody againstVP3 Protein of Duck Hepatitis A Type 1 Virus. Scientific Reports. 2017.7(1):10820.

8. Xiaojun Li, Ran Zhao, Wei Lin, Chenxo Li, Tingting Zhang, Fanyi Meng, Ming Liu, Yun Zhang * . Evidenceof VP1 of duck hepatitis A type 1 virus as a target of neutralizing antibodies and involving receptor-bindingactivity. Virus Res. 2017. 227:240-244.

9. Chenxi Li, Hongyu Liu, Jinzhe Li, Dafei Liu, Runze Meng, Qingshan Zhang, Shaozhou Wulin, Xiaofei Bai,Tingting Zhang, Ming liu, Yun Zhang * . A Conserved Epitope Mapped with a Monoclonal Antibody against theVP3 Protein of Goose Parvovirus by Using Peptide Screening and Phage Display Approaches. PLOS ONE. 2016.11(5): e0147361.

10. Xiaowei Chen, Cailing Song, Yun Liu, Liandong Qu, Dafei Liu, Zhigao Bu, Yun Zhang*, Ming liu*.Development of an ELISA Based on Fusion VP2 332-452 Antigen for Detecting Antibodies against AleutianMink Disease Virus. Journal of Clinical Microbiology. 2016.5 4(2):439-442.

11. Chenxi Li, Xiaofei Bai, Runze Meng, Wulin Shaozhou , Qingshan Zhang, Ronghong Hua, Jyung-Hurng Liu,Ming Liu, Yun Zhang *. A New Broadly Cross-reactive Epitope within Domain III Identified with MonoclonalAntibody against E Protein of Duck Tembusu Virus. Scientific Reports. 2016. 6:36288

12. Xiaofei Bai, Wulin ShaoZhou, Qingshan Zhang, Chenxi Li, Na Qiu, Ming Liu, Yun Zhang*, Meng R.Characterization of monoclonal antibodies against duck tembusu virus E protein: an antigen-capture ELISA forthe detection of tembusu virus infection. Arch. Virology. 2015. 160(3):757-64.

13. Wulin Shaozhou, Chenxi Li, Runzhe Meng, Qingshan Zhang, Youlan Gao, Hongyu Liu, Xiaofei Bai, YuhuanChen, Siguo Liu, Ming Liu, Yun Zhang * . Duck Tembusu Virus and Its Envelope Protein InduceProgrammed Cell Death. Virus Genes. 2015. OI10.1007/s11262-015-1200-2.

14. Xiaoying Wu, Xiaojun Li, Qingshan Zhang, Shaozhou Wulin, Xiaofei Bai, Tingting Zhang, Yue Wang, MingLiu, Yun Zhang * . Identification of a Conserved B-Cell Epitope on Duck Hepatitis A Type 1 Virus VP1 Protein.PLoS ONE 2015. 10(2): e0118041.

16. Xiaofei Bai. Rang Lv, ChunGuo Liu, Na Qiu, Yilong He, XiuChen Yin, XiaoJun Li, Ming Liu, Yun Zhang*.Molecular characterization of a duck Tembusu virus from China. Virus Genes. 2013. 47:478–482.

17. Guo Dongchun, Qiu Na, Shaozhou Wulin, Bai Xiaofei, He Yilong, Zhang Qingshan, Jian Zhao, Ming Liu,Yun Zhang*. Muscovy duck reovirus p10.8 protein localizes to the nucleus via a nonconventional nuclearlocalization signal. Virology Journal 2014, 11:37.

18. Tingting Zhang, Xi Li, Xiaoying Wu, Wulin Shaozhou, Xiaofei Bai, Yun Zhang*, S Liu, M Liu.Characterization of monoclonal antibodies against duck hepatitis type 1 virus VP1 protein. Journal of VirologicalMethods. 2014.208(7):166-170..

19. Xiuchen Yin, Rang Lv, Xiaodan Chen, Ming Liu, Ronghong Hua, Yun Zhang*. Detection of SpecificAntibodies against Tembusu Virus in Ducks by use of an E-ELISA. Journal of Clinical Microbiology. 2013.51(7):2400–2402.

20. Chun-Guo Liu, Ming Liu,*, Fei Liu, Rang Lv, Da-Fei Liu, Lian-Dong Qu, Yun Zhang*. Emerging multiplereassortant H5N5 avian influenza viruses in ducks, China. Veterinary Microbiology 167 (2013) 296–306.

21. Ming Liu, Chunguo Liu, Gang Li, Xiaojun Li, Xiuchen Yin, Yuhuan Chen, Yun Zhang*, Chen S. AdaptedTembusu-Like Virus in Chickens and Geese in China. Journal of Clinical Microbiology. 2012, 50(8):2807-2809.

22. Yongfeng Li, Xiuchen Yin, Xiaodan Chen, Xiaojun Li, Jinzhe Li, Chunguo Liu, Ming Liu∗, Yun Zhang*.Antigenic analysis monoclonal antibodies against different epitopes of B protein of Muscovy duck reovirus. VirusResearch. 163.2012 546–551.

23. Xiuchen Yin, Shumei Zhang, Youlan Gao, Jinzhe Li, Shuyi Tan, Hongyu Liu, Xiaoying Wu, Yuhuan Chen,Ming Liu*, Yun Zhang*. Characterization of monoclonal antibodies against waterfowl parvoviruses VP3 protein.Virology Journal 2012, 9:288

24. Ming Liu, Chun-Guo Liu, Yun Zhang*, Wei-Lin Shi, Wei Wang, Yan-Yun Liu. Efficacy of a high-yieldattenuated vaccine strain wholly derived from avian influenza viruses by use of reverse genetics. VeterinaryMicrobiology 2012, 161:43-48.

25. Ming Liu, Chunguo Liu, Gang Li, Xiaojun Li, Xiuchen Yin, Yuhuan Chen, Yun Zhang* Complete GenomicSequence of Duck Flavivirus from China. Journal of Virolology. 2012, 86(6):3398.

26. Ming Liu, Fanyi-Meng, Xiao-jun Li, Zhuo Zhang, Siguo Liu, Yun Zhang*. Goose haemorrhagic hepatitiscaused by a new subtype duck hepatitis type 1 virus. Veterinary Microbiology. 152 (2011) 280–283.

27. Chun G Liu, Ming Liu, Fei Liu, Da F Liu, Yun Zhang*, Wei Q Pan, Hao Chen, Chun H Wan, En C Sun, HongT Li, Wen H Xiang. Evaluation of several adjuvants in avian influenza vaccine to chickens and ducks. VirologyJournal 2011, 8:321.

28. Yun Zhang*, Yongfeng Li, Ming Liu, Dabing Zhang, Dongchun Guo, Chunguo Liu, Haidong Zhi, XiaomeiWang, Gang Li, Na Li, Shiguo Liu, Wenhua Xiang, Guangzhi Tong. Development and evaluation of VP3-ELISAfor detection of goose and Muscovy duck parvovirus antibodies. Journal of Virological Methods. 2010. 163405–409.

29. Yun Zhang*, Ming Liu, Yongfeng Li, Yin X, Chen X, Li X, Li J, Liu C. Identification of two epitopes on σBprotein of Muscovy duck reovirus. Virology Journal. 2010. 7:133 .

30. Ming Liu, Tingting Zhang, Yun Zhang*, Fanyi Meng, Xiaojun Li, Zhenzhong Hou, Xinchang Feng, XiangangKong. Development and evaluation of a VP1-ELISA for detection of antibodies to duck hepatitis type 1 virus.Journal of Virological Methods. 169 (2010) 66–69.

31. Hongwei Geng, Yun Zhang, Yin Liu-Partanen, Dongcun Guo, Vanhanseng, Yue Wang, Ming Liu, GuangzhiTong. Apoptosis induced by duck reovirus p10.8 protein in primary duck embryonated fibroblast and Vero E6cells. Avian Diseases. 2009.53(3):

32. Liu Ming，Pan weiqi, Liu Chunguo, Yang Tao, Zhang Yun, Liu Dafei, Chen Hualan. Rescue ofA/chicken/Guangdong/04(H5N1) influenza virus by reverse genetics and its pathogenic characterization in mice.Options for the control of influenza VI. Proceedings book, International Medical Press. 2008, 647-649.

33. Yun Zhang*, Ming Liu, Lindong Qu, Wenhua Xiang., Xiufang Yuan, Chun Zhang, Ming Ge. Sequence and phylogenetic analysis of S-class genome segments of a duck reovirus. Acta Virologica. 2007, 51: 239-247.

34. Weiqi Pan, Ming Liu, Yun Zhang*, Chunguo Liu, Tao Yang, Jingpeng Li. Rescue of H5N1 subtype avianinfluenza A virus lethal to mice. Chinese Journal of Agricultural Biotechnology. 2007,4(1)：87-92.

35. Yun Zhang*, Dongchun Guo, Hongwei Geng, Ming Liu, Qilin Hu, Junwei Wang, Tong G, Kong X, Liu N,Liu C. Characterization of M-class genome segments of muscovy duck reovirus S14. Virus Research. 2007. 125,42-53

36. Yun Zhang*, Dongchun Guo, Ming Liu, Hongwei Geng, Qilin Hu, Y Liu, N Liu. Characterization of theσB-encoding genes of musocvy duck reovirus: σC-σB-ELISA for antibodies against duck reovirus in ducks.Veterinary Microbiology. 2007, 121, 231-241.

37. Yun Zhang*, Ming Liu, Qilin Hu, Shuidong Ouyang, Tong G.Characterization of the C-encoding gene from Musocvy duck reovirus. Virus Gene. 2006, 36(2):165-170.

38. Yun Zhang*, Ming Liu, Ouyan Shuidong, Qilin Hu, Dongchun Guo, Chen HY, Zhou Han. Detection andIdentification of Avian, Duck, and Goose Reoviruses by RT-PCR: Goose and Duck Reoviruses aggregated theSame Specified Genogroup in Orthoreovirus Genus II. Arch Virol. 2006, 151(8), 1525-1538.

39. Chaonan Liu, Ming Liu, Yun Zhang *, Chun-guo Liu, Xue-li Gao. Pathogenicity of H5N1 Influenza Virus forDucks. Scientia Agricultura Sinica. 2006,39(2):412-417.

40. Yun Zhang*, Ming Liu. Kangzhen Yu, Robert G. Webster. Generation of recombinant equine influenzavaccine candidate rgH3N8 virus by reverse genetics. Agricultural Sciences in China. 2005, 4(4), 317-320.

获国家发明专利：

1.一管PCR式鉴别鹅细小病毒和番鸭细小病毒的试剂盒ZL201210324527.0 (第一)

2.抗新I型鸭肝炎病毒3D蛋白单克隆抗体ZL201110112160.1. (第一)

3.抗水禽细小病毒VP3蛋白单克隆抗体 ZL201010246095.7 (第一)

4.一管PCR鉴别I型鸭肝炎病毒和新I型鸭肝炎病毒的试剂盒ZL201210325598.2. (第一)

5.重组禽流感病毒毒株、其制备方法及由其制得的疫苗ZL200510077272.2. (第二)

6.重组犬流感病毒毒株、其制备方法及由其制备得到的疫苗, ZL201410082973.4. (第四)