代表性研究论文

1. Wei Liu, Junjun Shao, Guanglei Zhang, Yanyan Chang, Sudan Ge, YueSun, Zhan Gao, Huiyun Chang. Development of an Indirect ChemiluminescenceImmunoassay Using a Multiepitope Recombinant Protein To Specifically DetectAntibodies against Foot-and-Mouth Disease Virus Serotype O in Swine. J Clin Microbiol, 2021,59(3): e02464-20. doi: 10.1128/JCM.02464-20.

2.   Zhan Gao, Jun‑Jun Shao, Guang‑Lei Zhang, Su‑Dan Ge, Yan‑Yan Chang, Lei Xiao and Hui‑Yun Chang*.Development of an indirect ELISA to specifically detect antibodies againstAfrican swine fever virus: bioinformatics approaches. Virol J. 2021. PMID:33952293.

3.  Yao Lei, Jun-jun Shao, Feifei Ma, Chenglin Lei, Hui-yun Chang*,Yong-guang Zhang. Enhanced efficacy of a multi-epitope vaccine for type A and Ofoot-and-mouth disease virus by fusing multiple epitopes with Mycobaceriumtuberculosis hearin-binding hemagglutinin(HBHA), a novel TLR4 agonist.Molecular Immunology, 2020, 121: 118-126.

4.   Wei Liu, Junjun Shao, Danian Chen, Yanyan Chang, Huiyun Chang*,Yongguang Zhang*. Identification of three linear B cell epitopes againstnon-structural protein 3ABC of FMDV using monoclonal antibodies. Appl.Microbiol. Biotechnol. 2019, 103(19): 8075-8086.

5.  Yao Lei, Junjun Shao, Furong Zhao, Yangfan Li, Chenglin Lei, FeifeiMa, Huiyun Chang, Yongguang Zhang*. Artificially designed hepatitis B viruscore particles composed of multiple epitopes of type A and O foot-and-mouthdisease virus as a bivalent vaccine candidate. J Med Virol. 2019, 91: 2142-2152

6.  Li SF, Shao JJ, Zhao FR, Gong MJ, Xie YL, Chang HY, Zhang YG. Antiviralactivity of porcine interferon delta 8 against foot-and-mouth disease virus invitro. International Immunopharmacology, 2018, 59: 47–52.

7.  Liu Z, Shao J, Zhao F, Zhou G, Gao S, Liu W, Lv J, Li X, Li Y, ChangH*, Zhang Y. Chemiluminescence immunoassay for the detection of antibodies againstthe 2C and 3ABC nonstructural proteins induced by infecting pigs with thefoot-and-mouth disease virus. Clin Vaccine Immunol. 2017; 24(8). pii: e00153-17

8.  Yanyan Chang, Junjun Shao, Yuan Gao, Wei Liu, Zhan Gao, Yonghao Hu*; Huiyun Chang *. Reporter gene knock-in into Marc-145 cells usingCRISPR/Cas9-mediated homologous recombination. Biotechnology letters. Biotechnologyletters. 2020, 42: 1317-1325.

9.  Jun-jun Shao,Jing-feng Wang, Hui-yun Chang and Ji-xing Liu. Immune Potential of a NovelMultiple-epitope Vaccine to FMDV Type Asia 1 in Guinea Pigs and Sheep. VIROLOGICASINICA, 2011, 26 (3):190-197.

10. Jun-Jun Shao, Chung Kai Wong, Tong Lin, Shuk Kwan Lee,Guo-Zheng Cong, Fion Wai Yee Sin, Jun-Zheng Du, Shan-Dian Gao, Xiang-Tao Liu, Xue-PengCai, Yong Xie,* Hui-Yun Chang,* and Ji-Xing Liu. Promising Multiple-EpitopeRecombinant Vaccine against Foot-and-Mouth Disease Virus Type O in Swine. CLINICALAND VACCINE IMMUNOLOGY, 2011, 18(1): 143–149.

国家专利

1.  常惠芸；邵军军；李扬帆；张永光. 猪口蹄疫病毒O型、A型Fc多肽双价疫苗及其制备方法和应用. ZL201810074700.3

2.  常惠芸；吴俊清；邵军军；章健；赵付荣；吴冠英；张永光. O型口蹄疫病毒抗体检测卡. ZL201620057348.9

3.  常惠芸；邵军军；吴俊清；章健；刘泽众；吴冠英；李扬帆；王泽洲；赵付荣；张永光. 口蹄疫病毒非结构蛋白抗体的快速检测系统, ZL201721431759.0

4.   邵军军；常惠芸；吴俊清；章健；李扬帆；吴冠英；赵付荣；王泽洲；张永光. A型口蹄疫病毒抗体快速定量检测系统, ZL201721431760.3

5.   常惠芸；刘泽众；邵军军；赵付荣；李秀梅；张永光. 一种猪口蹄疫3ABC和2C抗体化学发光检测试剂盒，ZL201611051539.5

6.   常惠芸；刘泽众；邵军军；赵付荣；李秀梅；张永光. 一种牛口蹄疫3ABC抗体化学发光检测试剂盒，ZL201611052512.8

7.   常惠芸；邵军军；李扬帆；张永光. 猪口蹄疫O型、A型Fc多肽双价疫苗及其制备方法和应用，ZL201810074700.3

8.   邵军军；常惠芸；李扬帆；张永光. 猪口蹄疫O型Fc多肽疫苗及其制备方法和应用，ZL201810074696.0

9.   常惠芸；高瞻；邵军军；常艳燕. 一种非洲猪瘟重组抗原及其应用，ZL202010255206.4