Position

PI   (CAAS Chengdu, China)

Research topics

My main research goal is to analyze theproperties and catalytic mechanism of enzym es involved in archaea metabolism using X-ray crystallographic, biochemical and spectroscopic methods.

Education

Diplom (Dr. rer. nat):  Max Planck Institute for Terrestrial Microbiology, Marburg,Germany, September 2015 – June 2019. 

Advisor: Dr. Seigo Shima 

Master of Science: Departmentof Biochemistry andmolecular biology, Xiamen University, Xiamen, Peoples Republic China, September2012 – June 2015. 

Advisor: Prof. Dr.Qingxi Chen and Prof. Dr. Yan Shi 

Bachelor of Science: Department of Biotechnology, WenzhouUniversity, Wenzhou, People Republic China, September 2008 – June 2012.

Advisor: Prof. Xiaowei Zhao and Prof. Maohong Zhou

Selected publications(#These authors contributed equally to these works.)

1.   Huang, G., Wagner, T., Ermler, U., Shima, S. (2020)

Methanogenesis involves direct hydride transfer from H2 to an organic substrate. Nat. Rev. Chem. 4, 213–221.

2.  Huang, G.^#, Wagner, T.^#, Wodrich, M.D., Ataka, K. Bill, E., Ermler, U., Hu, X. & Shima, S. (2019)

The atomic-resolution crystal structure of activated [Fe]-hydrogenase. Nat. Catal. 2, 537–543.

3.   Pan, H-J, Huang, G., Wodrich, M.D. Tirani, F.F. Ataka, K., Shima, S.* & Hu, X.* (2019) 

A catalytically active [Mn]-hydrogenase incorporating a non-native metal cofactor. Nat. Chem.11, 669–675.

4.   Huang, G., Wagner, T., Ermler, U. Bill, E., Ataka, K. & Shima, S. (2018)

Dioxygen sensitivity of [Fe]-hydrogenase in the presence of reducing substrates. Angew. Chem. Int. Ed. 57, 4917–4920.

5.   Wagner, T.^#, Huang. G.^#, Ermler, U. & Shima, S. (2018) 

How [Fe]-hydrogenase from Methanothermobacter is protected against light and oxidative stress. Angew. Chem. Int. Ed. 57, 15056–15059.

Participate in researchprojects

1. German Natural Science Foundation Key Project: Deutsche Forschungsgemeinschaft Priority Program 1927 “Iron-Sulfurfor Life” (SH 87/1-1)

2. Fujian Natural Science Foundation Project (2013J01146): Study on Hydrogen Metabolism ofPhotosynthetic Bacteria Rhodopseudomonas palustris CN

3. National Natural Science Foundation of China (31170760): Analysis of the mechanism of hydrogenaseresistance of Klebsiella pneumoniae

Awards and scholarships

2015 - 2019  CSC Scholarship (China)

2014             Graduate National Scholarship(China)

2012 - 2015  Xiamen University Graduate Scholarship (FirstClass) (China)

2012             Excellent graduates of Zhejiang Province (China)

2008 - 2012  Wenzhou University Scholarship (First Class)(China)

Conferences

2019.09     Chemical biology Summer School 2019,Hirschegg, Austria. (Oral presentation)

2019.04     DFG “Iron-Sulfur-Life” meeting,Potsdam, Germany.

2019.04     12thInternational Conference on Hydrogenase, Lisbon, Portugal.

2019.03     AnnualConference of the Association for General and AppliedMicrobiology(VAAM) 2019, Mainz, Germany. (Oral presentation)

2018.10      DFG “Iron-Sulfur-Life” Summer School,Freiburg, Germany.

2018.09      Chemical biology Summer School 2018,Hirschegg, Austria. (Oral presentation)

2018.06      1st Hydrogenase Minisymposium, Berlin, Germany. (Oral presentation)

2017.03      AnnualConference of the Association for General and Applied Microbiology(VAAM) 2017, Würzburg, Germany.

2016.09      Chemical biology Summer School 2016,Hirschegg, Austria. (Oral presentation)

2015.09      Chemical biology Summer School 2015,Hirschegg, Austria. (Oral presentation)