马传染病与慢病毒病创新团队由首席科学家（研究员1人）、科研骨干（副研究员9人）、研究助理（助理研究员2人）和科研助理（4人）及多名在读博士、硕士研究生组成。

团队主要开展以下几方面研究工作：

（1）病毒与宿主天然免疫相互作用研究。揭示宿主天然免疫与病毒间的相互作用分子机理，重点关注宿主免疫压力对逆转录病毒、流感病毒等进化的促进作用及机制、病原跨种间感染机制。

（2）马属动物传染病病原的致病与免疫机制研究。 深入开展马传贫病毒、马流感病毒和马疱疹病毒等病原的基因功能研究，病毒致病的分子机理，以及疫苗免疫保护机理研究。

（3）马属动物重要传染病的流行病学和防控应用技术研究。重点关注马属动物传染病的诊断和防控用生物制品的研发，创建新型传染病诊断试剂盒、预防及治疗用疫苗，形成系列防控用生物工程技术产品体系，服务于全国的马病防治。

主持和参加的的科研项目：

1. 国家自然科学基金（面上项目），32172831、马传染性贫血病毒新编码蛋白S4调控病毒复制的分子机制研究、2022/01-2025/12、58万元、主持。

2. 国家自然科学基金（面上项目），32170169、马传染性贫血病毒新编码蛋白MAT的表达调控机制及其生物学功能研究、2022/01-2025/12、58万元、参加。

3. 国家自然科学基金（面上项目），31672578、马传染性贫血病毒囊膜蛋白羧基端调控病毒复制的分子机制研究、2017/01-2020/12、62万元、主持。

4. 国家自然科学基金（面上项目），31572537、马传染性贫血病强弱毒株感染造成靶细胞线粒体损伤差异的研究、2016/01-2019/12、64万元、参加。

5. 国家自然科学基金（青年科学基金项目），31302066、马传染性贫血病毒弱毒疫苗株和亲本强毒株的体内进化及其与免疫应答关系研究、2014/01-2016/12、22万元、主持。

6. 中国博士后科学基金，2015M571387、马传贫病毒弱毒疫苗基因进化与免疫保护关系研究、2014/09-2017/12 、5万元、主持。

7. 黑龙江省博士后科研启动资助（2020年）LBH-Q20059、10万元，主持。

8. 黑龙江省自然科学基金面上项目，C2017076、马传染性贫血病毒Rev蛋白相互作用的宿主蛋白筛选及其分子机制研究、2017/10-2020/10，6万元，主持。

9. 黑龙江省博士后基金，LBH-Z14033、马传贫病毒弱毒疫苗囊膜基因进化及其多样性及其多样性与免疫保护关系研究、2014/12-2017 /12 、7万元、主持。

10. 上海市兽医生物技术重点实验室开放课题，klab201705、EIAV囊膜蛋白羧基端调控囊膜蛋白表达的分子机制研究（2017.12.01-2019.12.01）、5万元，主持。

1. Xue-Feng Wang, Yuhong Wang, Bowen Bai, Mengmeng Zhang, Jie Chen, Xiangmin Zhang, Min Gao, Xiaojun Wang*. Truncation of the cytoplasmic tail of equine infectious anemia virus increases virion production by improving Env cleavage and plasma membrane localization. J Virol. 2021 Sep 8:JVI0108721. doi: 10.1128/JVI.01087-21. Epub ahead of print. PMID:34495693.

2. 王雪峰，张相敏，林跃智，杜承，王晓钧*. 马传染性贫血病毒弱毒疫苗致弱及免疫保护机制研究进展，2021，生命科学，33(1): 26-35.

3. Huiling Ren, Xin Yin, Chao Su, Miaomiao Guo, Xue-Feng Wang, Lei Na, Yuezhi Lin, Xiaojin Wang*. Equine lentivirus counteracts SAMHD1 restriction by Rev-mediated degradation of SAMHD1 via the BECN1-dependent lysosomal pathway. Autophagy, 2020,1-18  

4. Yuezhi Lin#, Xue-Feng Wang#, Yuhong Wang, Cheng Du, Huiling Ren, Cong Liu, Dantong Zhu, Jie Chen, Lei Na, Diqiu Liu, Zhibiao Yang and Xiaojun Wang*. Env diversity-dependent protection of the attenuated equine infectious anaemia virus vaccine. Emerging Microbes & Infections, 2020, 9(1): 1309-1320. 

5. Bai bowen#, Wang Xue-Feng#, Zhang Mengmeng, Na Lei, Zhang Xiangmin, Zhang Haili, Yang Zhibiao, Wang Xiaojun*. The N-glycosylation of Equine Tetherin Affects Antiviral Activity by Regulating Its Subcellular Localization. Viruses, 2020, 12(220): 1-15.  

6. Wang XF#, Bai B#, Lin Y, Qi T, Du C, Song M, Wang X: High-Efficiency Rescue of Equine Infectious Anemia Virus from a CMV-Driven Infectious Clone. Virol. Sin. 2019，34, 725–728.

7. Liu C, Wang XF#, Wang Y, Chen J, Zhong ZH, Lin YZ, Wang XJ: Characterization of EIAV env Quasispecies during Long-Term Passage In Vitro: Gradual Loss of Pathogenicity. Viruses, 2019, 11(4).

8. Yu C#, Wang X#, Zhou Y, Wang Y, Zhang X, Zheng Y: Genotyping bovine leukemia virus in dairy cattle of Heilongjiang, northeastern China. BMC Vet Res 2019, 15(1):179. 

9. Wang Xue-Feng, Liu Qiang, Wang Yu-Hong, Wang Shuai, Chen Jie, Lin Yue-Zhi, Ma Jian, Zhou Jian-Hua, Wang Xiaojun. 2018, Characterization of EIAV LTR quasispecies in vitro and in vivo. J Virol, 2018, 92(8):e02150-17.

10. Wang, Xue-Feng#; Lin, Yue-Zhi#; Li, Qiang; Liu, Qiang; Zhao, Wei-Wei; Du, Cheng; Chen, Jie; Wang, Xiaojun; Zhou, Jian-Hua, Genetic Evolution during the development of an attenuated EIAV vaccine.,  2016, Retrovirology, 13(1): 9. 

11. Wang, Xue-Feng; Wang, Shuai; Liu, Qiang; Lin, Yue-Zhi; Du, Cheng; Tang, Yan-Dong; Na, Lei; Wang, Xiaojun; Zhou, Jian-Hua, A unique evolution of the s2 gene of equine infectious anemia virus in hosts correlated with particular infection statuses., 2014, Viruses, 6(11): 4265-4279.

12. Du, Jiansen#; Wang, Xuefeng#; Ma, Jing; Wang, Jianxin; Qin, Yuyin; Zhu, Chunhui; Liu, Fang; Shao, Yiming; Zhou, Jianhua; Qiao, Wentao; Liu, Xinqi, Structural and biochemical insights into the V/I505T mutation found in the EIAV gp45 vaccine strain., 2014 , Retrovirology, 11:26.

13. Wang Xuefeng; Wang Shuai; Lin Yuezhi; Jiang Chenggang; Ma Jian; Zhao Liping; Lv Xiaoling; Wang Fenglong; Shen Rongxian; Zhou Jianhua, Unique evolution characteristics of the envelope protein of EIAV(LN40), a virulent strain of equine infectious anemia virus,2011, Virus Genes, 42(2):220-228.  

14. Wang Xuefeng; Wang Shuai; Lin Yuezhi; Jiang Chenggang; Ma Jian; Zhao Liping; Lv Xiaoling;  Wang Fenglong; Shen Rongxian; Kong Xiangang; Zhou Jianhua, Genomic comparison between attenuated Chinese equine infectious anemia virus vaccine strains and their parental virulent strains, 2011,  Archives of Virology, 156(2):353-357.  

15. Qi Xu#; Wang Xuefeng#; Wang Shuai; Lin Yuezhi; Jiang Chenggang; Ma Jian; Zhao Liping; Lv Xiaoling; Shen Rongxian; Wang Fenglong; Kong Xiangang; Su Zhiqiang; Zhou Jianhua, Genomic analysis of an effective lentiviral vaccine-attenuated equine infectious anemia virus vaccine EIAV(FDDV13), 2010, Virus Genes, 41(1):  86-98. 

16. Du Cheng; Duan Yingyi; Wang Xue-Feng; Lin YueZhi; Na Lei; Wang Xinhui; Chen Kewei; Wang Xiaojun*; Attenuation of Equine Lentivirus Alters Mitochondrial Protein Expression Profile from Inflammation to Apoptosis, 2019, Journal of Virology, 93(21): e00653-19.

17. Zhang Haili#; Zhang Zhenyu#; Wang Yujie; Wang Meiyue; Wang Xuefeng; Zhang Xiang; Ji Shuang; Du Cheng; Chen Hualan; Wang Xiaojun*; Fundamental Contribution and Host Range Determination of ANP32A and ANP32B in Influenza A Virus Polymerase Activity, 2019, Journal of Virology, 93(13): e00174-19.

18. Fatima Urooj; Zhang Zhenyu; Zhang Haili; Wang Xue-Feng; Xu Ling; Chu Xiaoyu; Ji Shuang; Wang Xiaojun, Equine Mx1 Restricts Influenza A Virus Replication by Targeting at Distinct Site of its Nucleoprotein., 2019, Viruses, 11, 1114.

19. Liu Qiang, Wang Xue-Feng, Du Cheng, Lin Yue-Zhi, Ma Jian, Wang Yu-Hong, Zhou Jian-Hua, Wang Xiaojun. 2017. The integration of a macrophage-adapted live vaccine strain of equine infectious anaemia virus (EIAV) in the horse genome. J Gen Virol, 98:2596-2606.

20. Liu Qiang; Wang Xue-Feng; Ma Jian; He Xi-Jun; Wang Xiao-Jun; Zhou Jian-Hua, Characterization of Equine Infectious Anemia Virus Integration in the Horse Genome., 2015, Viruses, 7(6):3241-3260. 

21. Duan Liangwei; Du Jiansen; Wang Xuefeng; Zhou Jianhua; Wang Xiaojun; Liu Xinqi, Structural and functional characterization of EIAV gp45 fusion peptide proximal region and asparagine-rich layer., 2016, Virology, 491:64-72. 3.353

22. Liu Qiang; Ma Jian; Wang Xue-Feng; Xiao Fei; Li Li-Jia; Zhang Jiao-Er; Lin Yue-Zhi; Du Cheng;   He Xi-Jun; Wang Xiaojun; Zhou Jian-Hua, Infection with equine infectious anemia virus vaccine strain EIAVDLV121 causes no visible histopathological lesions in target organs in association with restricted viral replication and unique cytokine response., 2016, Vet Immunol Immunopathol, 170: 30-40. 1.718

23. Gao Xu; Jiang Cheng-Gang; Wang Xue-Feng; Lin Yue-Zhi; Ma Jian; Han Xiu-E; Zhao Li-Ping; Shen Rong-Xian; Xiang Wen-Hua; Zhou Jian-Hua, Reverse mutation of the virulence-associated S2 gene does not cause an attenuated equine infectious anemia virus strain to revert to pathogenicity., 2013, Virology.

24. Tang YD, Zhang X, Na L, Xue-Feng Wang, Fu LH, Zhu CH, Xiaojun Wang, Jian-Hua Zhou. Double-stranded-RNA-specific adenosine deaminase 1 (ADAR1) is proposed to contribute to the adaptation of equine infectious anemia virus from horses to donkeys, 2016, Archives of virology, 161(10):2667-72.

25. Du Cheng; Liu Hai-Fang; Lin Yue-Zhi; Wang Xue-Feng; Ma Jian; Li Yi-Jing; Wang Xiaojun;   Zhou Jian-Hua, Proteomic alteration of equine monocyte-derived macrophages infected with equine infectious anemia virus., 2015, Proteomics.

26. Lin Yue-Zhi，Sun Liu-Ke，Zhu Dan-Tong，Hu Zhe，Wang Xue-Feng，Du Cheng，Wang Yu-Hong，Wang Xiao-Jun，Zhou Jian-Hua，Equine schlafen 11 restricts the production of equine infectious anemia virus via a codon usage-dependent mechanism，2016，Virology，495：112-21. 2016.5.21

27. Hu Zhe; Chang Hao; Ge Man; Lin Yuezhi; Wang Xuefeng; Guo Wei; Wang Xiaojun, Development of antigen capture ELISA for the quantification of EIAV p26 protein., 2014, Applied Microbiology and Biotechnology, 98(21):9073-9081.  

28. Tang YD, Na L, Fu LH, Yang F, Zhu CH, Tang L, Li Qiang, Jia-Yi Wang, Zhan Li , Wang Xue-Feng, Cheng-Yao Li, Xiaojun Wang, Jian-Hua Zhou. Double-stranded RNA-specific adenosine deaminase 1 (ADAR1) promotes EIAV replication and infectivity.,2015, Virology, 476(1):364-371. 

29. Du Cheng; Ma Jian; Liu Qiang; Li Yun-Fei; He Xi-Jun; Lin Yue-Zhi; Wang Xue-Feng; Meng Qing-Wen; Wang Xiaojun; Zhou Jian-Hua, Mice transgenic for equine cyclin T1 and ELR1 are susceptible to equine infectious anemia virus infection., 2015, Retrovirology, 12:36.

30. Tang Yan-Dong; Na Lei; Zhu Chun-Hui; Shen Nan; Yang Fei; Fu Xian-Qiu; Wang Yu-Hong; Fu Li-Hua; Wang Jia-Yi; Lin Yue-Zhi; Wang Xue-Feng; Wang Xiaojun; Zhou Jian-Hua; Li Cheng-Yao, Equine viperin restricts equine infectious anemia virus replication by inhibiting the production and/or release of viral Gag, Env, and receptor via distortion of the endoplasmic reticulum., 2014, Journal of Virology, 88(21):12296-12310.

31. Ma Jian; Wang Shan-Shan; Lin Yue-Zhi; Liu Hai-Fang; Liu Qiang; Wei Hua-Mian; Wang Xue-Feng; Wang Yu-Hong; Du Cheng; Kong Xian-Gang; Zhou Jian-Hua; Wang, Xiaojun, Infection of equine monocyte-derived macrophages with an attenuated equine infectious anemia virus (EIAV) strain induces a strong resistance to the infection by a virulent EIAV strain, 2014, Veterinary Research, 45:30-40. 

32. Na Lei; Tang Yan-Dong; Liu Jian-Dong; Yu Chang-Qing; Sun Liu-Ke; Lin Yue-Zhi; Wang Xue-Feng; Wang Xiaojun; Zhou Jian-Hua, TRIMe7-CypA, an alternative splicing isoform of TRIMCyp in rhesus macaque, negatively modulates TRIM5alpha activity., 2014, Biochem Biophys Res Commun, 446(2):470-474.

33. Ma Jian; Wang Shan-Shan; Lin Yue-Zhi; Liu Hai-Fang; Wei Hua-Mian; Du Cheng; Wang Xue-Feng;  Zhou Jian-Hua, An attenuated EIAV strain and its molecular clone strain differentially induce the expression of Toll-like receptors and type-I interferons in equine monocyte-derived macrophages., 2013, Veterinary Microbiology, 166(1-2),:263-269.

34. Lin Yue-Zhi; Yang Fei; Zhang Shu-Qin; Sun Liu-Ke; Wang Xue-Feng; Du Cheng; Zhou Jian-Hua, The Soluble Form of the EIAV Receptor Encoded by an Alternative Splicing Variant Inhibits EIAV Infection of Target Cells., 2013, PLos One, 8(11):e79299. 

35. Lin Yue-Zhi; Shen Rong-Xian; Zhu Zhen-Ying; Deng Xi-Lin; Cao Xue-Zhi; Wang Xue-Feng; Ma Jian;  Jiang Cheng-Gang; Zhao Li-Ping; Lv,Xiao-Ling; Shao Yi-Ming; Zhou Jian-Hua, An attenuated EIAV vaccine strain induces significantly different immune responses from its pathogenic parental strain although with similar in vivo replication pattern, 2011, Antiviral Research, 92(2):292-304. 

36. Lin Yue-Zhi; Cao Xue-Zhi; Li Liang; Li Li; Jiang Cheng-Gang; Wang Xue-Feng; Ma Jian; Zhou Jian-Hua, The pathogenic and vaccine strains of equine infectious anemia virus differentially induce cytokine and chemokine expression and apoptosis in macrophages, 2011, Virus Research, 160(1-2):274-282. 

37. Jiang Cheng-Gang; Gao Xu; Ma Jian; Lin Yue-Zhi; Wang Xue-Feng; Zhao Li-Ping; Hua Yue-Ping; Liu Di; Zhou Jian-Hua, C-terminal truncation of the transmembrane protein of an attenuated lentiviral vaccine alters its in vitro but not in vivo replication and weakens its potential pathogenicity, 2011, Virus Research, 158(1-2):235-245. 

38. Ma Jian; Shi Nan; Jiang Cheng-Gang; Lin Yue-Zhi; Wang Xue-Feng; Wang Shuai; Lv Xiao-Ling; Zhao Li-Ping; Shao Yi-Ming; Kong Xian-Gang; Zhou Jian-Hua; Shen, Rong-Xian, A proviral derivative from a reference attenuated EIAV vaccine strain failed to elicit protective immunity, 2011, Virology, 410(1): 96-106. 

39. Ma Jian; Jiang Chenggang; Lin Yuezhi; Wang Xuefeng; Zhao Liping; Xiang Wenhua; Shao Yiming;   Shen Rongxian; Kong Xiangang; Zhou Jianhua, In vivo evolution of the gp90 gene and consistently low plasma viral load during transient immune suppression demonstrate the safety of an attenuated equine infectious anemia virus (EIAV) vaccine, 2009, Archives of Virology, 154(5):867-873.