导师风采
马志永
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个人信息

Personal Information

  • 研究员
  • 导师类别:硕士,博士生导师
  • 性别: 男
  • 学历:博士研究生
  • 学位:博士

联系方式

Contact Information

  • 所属院系:上海兽医所
  • 所属专业: 兽医
  • 邮箱 : zhiyongma@shvri.ac.cn
  • 工作电话 : 021-34293139

个人简介

Personal Profile

马志永,男,博士,研究员,博士导师,猪呼吸道传染病团队,所长,上海市畜牧兽医学会副理事长兼秘书长。主要开展乙型脑炎等人畜共患病研究,探究宿主先天性抗病毒反应机制及病毒逃逸机制,寻找抗病毒药物设计的靶标分子,研发新型诊断技术和疫苗。主持转基因重大专项、“973”计划课题、公益性行业项目课题、国家自然科学基金等国家、省部级科研课题多项,发表学术论文100多篇,其中在《Plos Pathogens》《J Virol》、《Mol Cell Biol》、《J Biol Chem.》等杂志上发表SCI论文50多篇。培养博士硕士研究生20多名。


  • 研究方向Research Directions
人畜共患病及兽医公共卫生学
2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行整体布局设计。 整体布局设计。
科研项目

1.政府间国际科技创新合作重点专项:新型高效安全的猪链球菌BoHV-4活载体疫苗研究(2018YFE0101300),2019.08.01-2022.07.30,495万(主持人)。

2.上海科委农业重点科技攻关项目:乙型脑炎病毒基因I型弱毒苗研究(17391901600,2017.12-2021.12),80万(主持人)。

3.国家国际科技合作专项(2014DFE30140)“乙脑病毒优势型别变化的生态流行病学及风险”(2014.12.01-2017.11.30) 127万,(主持人)。

4.国家重点基础研究发展计划(973计划)课题(2014CB542702)“猪繁殖与呼吸综合征病毒的免疫抑制与免疫逃逸机制”(2014.1-2018.12),394万(主持人)。

5.国家自然基金项目(81371814)“日本脑炎病毒抑制p53转录活性的机制及在病毒复制中的作用解析”(2014.01-2017.12),70万(主持人)。


研究成果

1.Hameed M, Wahaab A, Nawaz M, Khan S, Nazir J, Liu K, Wei J, Ma Z. Potential Role of Birds in Japanese Encephalitis Virus Zoonotic Transmission and Genotype Shift. Viruses. 2021 Feb 24;13(3):357. doi: 10.3390/v13030357. PMID: 33668224; PMCID: PMC7996159.

2.Zongjie Li, Jianchao Wei, Di Di, Xin Wang, Chenxi Li, Beibei Li, Yafeng Qiu, Ke Liu, Feng Gu, Minglong Tong, Shuiming Wang, Xiaodong Wu, Zhiyong Ma, Rapid and accurate detection of African swine fever virus by DNA endonuclease-targeted CRISPR trans reporter assay, Acta Biochimica et Biophysica Sinica, , gmaa135, https://doi.org/10.1093/abbs/gmaa135

3.Wang X, Wu Z, Li Y, Yang Y, Xiao C, Liu X, Xiang X, Wei J, Shao D, Liu K, Deng X, Wu J, Qiu Y, Li B, Ma Z. p53 promotes ZDHHC1-mediated IFITM3 palmitoylation to inhibit Japanese encephalitis virus replication. PLoS Pathog. 2020 Oct 27;16(10):e1009035. doi: 10.1371/journal.ppat.1009035. Epub ahead of print. PMID: 33108395.

4.Xiang X, Zhang Y, Li Q, Wei J, Liu K, Shao D, Li B, Olszewski MA, Ma Z, Qiu Y. Expression profile of porcine scavenger receptor A and its role in bacterial phagocytosis by macrophages. Dev Comp Immunol. 2020 Mar;104:103534. doi: 10.1016/j.dci.2019.103534. Epub 2019 Nov 2. PMID: 31689452.

5.Xi S, Liu K, Xiao C, Hameed M, Ou A, Shao D, Li B, Wei J, Qiu Y, Miao D, Ma Z. Establishment and characterization of the pig tonsil epithelial (PT) cell line as a new model for persist infection of Japanese Encephalitis Virus. Vet Microbiol. 2020 Mar;242:108587. doi: 10.1016/j.vetmic.2020.108587. Epub 2020 Jan 18. PMID: 32122591.

6.Wang Z, Zhang Y, Wang L, Wei J, Liu K, Shao D, Li B, Liu L, Widén F, Ma Z, Qiu Y. Comparative genomic analysis of Bordetella bronchiseptica isolates from the lungs of pigs with porcine respiratory disease complex (PRDC). Infect Genet Evol. 2020 Jul;81:104258. doi: 10.1016/j.meegid.2020.104258. Epub 2020 Feb 19. PMID: 32087347.

7.Lu Y, Zhang Y, Xiang X, Sharma M, Liu K, Wei J, Shao D, Li B, Tong G, Olszewski MA, Ma Z, Qiu Y. Notch signaling contributes to the expression of inflammatory cytokines induced by highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) infection in porcine alveolar macrophages. Dev Comp Immunol. 2020 Jul;108:103690. doi: 10.1016/j.dci.2020.103690. Epub 2020 Mar 25. PMID: 32222356.

8.Wei J, Hameed M, Wang X, Zhang J, Guo S, Anwar MN, Pang L, Liu K, Li B, Shao D, Qiu Y, Zhong D, Zhou B, Ma Z. Antiviral activity of phage display-selected peptides against Japanese encephalitis virus infection in vitro and in vivo. Antiviral Res. 2020 Feb;174:104673. doi: 10.1016/j.antiviral.2019.104673. Epub 2019 Dec 5. PMID: 31812636.

9.Di D, Li C, Zhang J, Hameed M, Wang X, Xia Q, Li H, Xi S, Li Z, Liu K, Li B, Shao D, Qiu Y, Wei J, Ma Z. Experimental Infection of Newly Hatched Domestic Ducklings via Japanese Encephalitis Virus-Infected Mosquitoes. Pathogens. 2020 May 12;9(5):371. doi: 10.3390/pathogens9050371. PMID: 32408553; PMCID: PMC7281460.

10.Li C, Di D, Huang H, Wang X, Xia Q, Ma X, Liu K, Li B, Shao D, Qiu Y, Li Z, Wei J, Ma Z. NS5-V372A and NS5-H386Y variations are responsible for differences in interferon α/β induction and co-contribute to the replication advantage of Japanese encephalitis virus genotype I over genotype III in ducklings. PLoS Pathog. 2020 Sep 3;16(9):e1008773. doi: 10.1371/journal.ppat.1008773. PMID: 32881988; PMCID: PMC7494076.

11.Liu K, Xiao C, Xi S, Hameed M, Wahaab A, Shao D, Li Z, Li B, Wei J, Qiu Y, Miao D, Zhu H, Ma Z. Mosquito Defensins Enhance Japanese Encephalitis Virus Infection by Facilitating Virus Adsorption and Entry within the Mosquito. J Virol. 2020 Oct 14;94(21):e01164-20. doi: 10.1128/JVI.01164-20.

12.Anwar MN, Wang X, Hameed M, Wahaab A, Li C, Sharma M, Pang L, Malik MI, Liu K, Li B, Qiu Y, Wei J, Ma Z. Phenotypic and Genotypic Comparison of a Live-Attenuated Genotype I Japanese Encephalitis Virus SD12-F120 Strain with Its Virulent Parental SD12 Strain. Viruses. 2020 May 16;12(5):552. doi: 10.3390/v12050552. PMID: 32429445; PMCID: PMC7290960.

13.Hameed M, Khan S, Xu J, Zhang J, Wang X, Di, Chen Z, Anwar MN, Wahaab A, Ma X, Nawaz M, Liu K, Li B, Shao D, Qiu Y, Wei J, Ma Z. Detection of Japanese Encephalitis Virus in Mosquitoes from Xinjiang during Next Generation Sequencing Arboviral Surveillance. Transbound Emerg Dis. 2020 Jul 2. doi: 10.1111/tbed.13697. Epub ahead of print. PMID: 32614516.

14.Hameed M, Liu K, Anwar MN, Wahaab A, Li C, Di D, Wang X, Khan S, Xu J, Li B, Nawaz M, Shao D, Qiu Y, Wei J, Ma Z. A viral metagenomic analysis reveals rich viral abundance and diversity in mosquitoes from pig farms. Transbound Emerg Dis. 2020 Jan;67(1):328-343. doi: 10.1111/tbed.13355. Epub 2019 Oct 13. PMID: 31512812.

15.Hameed M, Liu K, Anwar MN, Wahaab A, Safdar A, Di D, Boruah P, Xu J, Wang X, Li B, Zhu H, Nawaz M, Shao D, Qiu Y, Wei J, Ma Z. The emerged genotype I of Japanese encephalitis virus shows an infectivity similar to genotype III in Culex pipiens mosquitoes from China. PLoS Negl Trop Dis. 2019 Sep 26;13(9):e0007716. doi: 10.1371/journal.pntd.0007716. eCollection 2019 Sep.

16.Li C, Di D, Wang X, Xia Q, Wahaab A, Anwar MN, Li Z, Liu K, Shao D, Qiu Y, Wei J, Li B, Ma Z. Duck karyopherin α4 (duKPNA4) is involved in type I interferon expression and the antiviral response against Japanese encephalitis virus. Dev Comp Immunol. 2019 Nov 5;104:103535. doi: 10.1016/j.dci.2019.103535. [Epub ahead of print]

17.Xiang X, Zhang Y, Li Q, Wei J, Liu K, Shao D, Li B, Olszewski MA, Ma Z, Qiu Y. Expression profile of porcine scavenger receptor A and its role in bacterial phagocytosis by macrophages. Dev Comp Immunol. 2019 Nov 2;104:103534. doi: 10.1016/j.dci.2019.103534. [Epub ahead of print]

18.Wei J, Wang X, Zhang J, Guo S, Pang L, Shi K, Liu K, Shao D, Qiu Y, Liu L, Widén F, Li B, Ma Z. Partial cross-protection between Japanese encephalitis virus genotype I and III in mice. PLoS Negl Trop Dis. 2019 Aug 2;13(8):e0007601. doi: 10.1371/journal.pntd.0007601. eCollection 2019 Aug.

19.Liu K, Ma G, Liu X, Lu Y, Xi S, Ou A, Wei J, Li B, Shao D, Li Y, Qiu Y, Miao D, Ma Z. Porcine reproductive and respiratory syndrome virus counteracts type I interferon-induced early antiviral state by interfering IRF7 activity. Vet Microbiol. 2019 Feb;229:28-38. doi: 10.1016/j.vetmic.2018.12.015.


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