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胡森,男,博士,研究员,硕士研究生导师。主要从事布鲁氏菌分子致病机理与免疫调控研究,从分子水平揭示不同菌株毒力差异关键因子及胞内生存机制,相关研究发表在细菌学杂志、传染与免疫、兽医微生物等杂志。在布病应用研究方面,研发了马耳他种布鲁氏菌病基因缺失疫苗(M5-90Δ26)、布鲁氏菌c-ELISA抗体检测试剂盒(农业部Ⅱ类新兽药证书(2013)新兽药证字27号)、布鲁氏菌抗体胶体金检测试纸条,解决了布病防控中关键瓶颈问题,实现产业化并得到大规模应用。主持国家自然基金面上项目、国家自然基金青年项目、黑龙江省自然基金面上项目、十三五和十四五国家重点研发项目子课题,参与国家863计划、行业公关、十三五重点研发项目等20多项。发表文章40多篇、SCI14篇。参编著作2部。获得专利授权3项。获得中国农业科学院科技进步二等奖1项,培养硕博士研究生20多人。
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支持扩展名:.rar .zip .doc .docx .pdf .jpg .png .jpeg1、国家重点研发计划:畜禽重要病原菌生长代谢和毒力调控机制,子课题“布鲁氏菌非编码sRNA调控持续感染的分子机制研究”。2022.01~2025.12
2、国家自然基金(面上):非编码sRNAClu7调控布鲁氏菌胞内持续感染的分子机制研究,32172854,2022.01~2025.12
3、国家重点研发计划:中国-哈萨克斯坦跨境动物疫病防控联合研究及“一带一路”科技合作平台建设,2020YFE0203400,2020.11~2023.10
4、国家重大科技专项、2012ZX10004-214-003、动物布氏杆菌病原谱流行规律研究、2012/01-2015/12。
5、国家自然科学基金(青年)、31001068、外膜合成代谢相关基因对布鲁氏菌弱毒株M5-90致弱机制的影响、2011/01-2013/12。
6、黑龙江省自然基金(面上项目)、C2016062)、布鲁氏菌强弱毒株感染后宿主差异表达microRNA及其功能的研究、2016/7-2019/7。
7、“十三五”国家重点研发计划、2017YFD0500300、畜禽重要胞内菌基因调控及其与宿主互作的分子机制研究、2017/7-2020/7。
8、中国农业科学院科技创新工程协同创新任务、CAAS-XTCX201611-01、奶牛绿色提质增效技术集成创新、2017/1-2020/12。
1、Comparisonof transcriptional change of B. melitensis M5-90 after macrophage infectionhighlights the role of ribosome gene L31 in virulence.VetMicrobiol.2021. 253:108951.
2、Anovel small RNA Bmsr1 enhances virulence in Brucella melitensis M28.VetMicrobiol.2018,223:1-8.
3、Deep-SequencingAnalysis of the Mouse Transcriptome Response to Infection with Brucellamelitensis Strains of Differing Virulence.PLosOne.2011, 6(12): 1-13.
4、CompleteGenome Sequences of Brucella melitensis Strains M28 and M5-90, with DifferentVirulence Backgrounds.Journalof Bacteriology.2011,193(11):2904-2905.
5、Comparisonof Genomes of Brucella melitensis M28 and the B. melitensis M5-90 DerivativeVaccine Strain Highlights the Translation Elongation Factor Tu Gene tuf2 as anAttenuation-Related Gene.Infect Immun.2013,81(8):2812-2818.
6、Thetwin arginine translocation system is important for stress resistance andvirulence of Brucella melitensis.Infect Immun.2020 Aug 10;IAI.00389-20. doi: 10.1128/IAI.00389-20.
7、Agoat poxvirus-vectored peste-des-petits-ruminants vaccine induces long-lastingneutralization antibody to high levels in goats and sheep.Vaccine.2010,28(30):4742-4750.
8、Expression,purification, and improved antigenic specificity of a truncated recombinantbp26 protein of Brucella melitensis M5-90: A potential antigen for differentialserodiagnosis of brucellosis in sheep and goats.Biotechnologyand Applied Biochemistry.2011,58(1):32-38.
9、An Extracytoplasmic Function Sigma/Anti-Sigma Factor System Regulates Hypochlorous Acid Resistance and impacts Expression of the Type IV Secretion System in Brucella melitensis.Journal of Bacteriology.203:e00127-21.
https://doi.org/10.1128/JB.00127-21.
10、Proteomics Investigation of the Time Course Responses of RAW264.7 Macrophages to Infections With the Wild-Type and Twin-Arginine Translocation Mutant Strains of Brucella melitensis.Frontiers in Cellular and Infection Microbiology.11:679571.
doi: 10.3389/fcimb.2021.679571
11、ChenWeiye#, Hu Sen, Qu Linmao,Hu Qianqian, Zhang Qian, Zhi Haibing, Huang Kehe, Bu Zhigao*, A goat poxvirus-vectoredpeste-des-petits-ruminants vaccine induces long-lasting neutralization antibodyto high levels in goats and sheep, Vaccine, 2010,28(30):4742-4750.
12、ChenWeiye#, Cao, Wenyan, Zhao, Huijun, Hu, Qianqian, Qu, Linmao, Hu, Sen, Ge, Jinying, Wen, Zhiyuan,Wang, Xijun, Li, HaoBo, Huang, Kehe, Bu, Zhigao*, Establishment of a stable CHOcell line with high level expression of recombinant porcine IFN-beta, Cytokine,2011,54(3):324-329.
13、GeJinying#, Deng Guohua, Wen Zhiyuan, Tian Guobin, Wang Yong, Shi Jianzhong,Wang, Xijun, Li Yanbing, Hu Sen,Jiang Yongping, Yang Chinglai, Yu Kangzhen, Bu Zhigao*, Chen Hualan, Newcastledisease virus-based live attenuated vaccine completely protects chickens andmice from lethal challenge of homologous and heterologous H5N1 avian influenzaviruses, Journal of Virology, 2007,81(1):150-158.
14、HuaRong-Hong#, Chen Na-Sha, Qin Cheng-Feng, Deng Yong-Qiang, Ge Jin-Ying, Wang Xi-Jun,Qiao Zu-Jian, Chen Wei-Ye, Wen Zhi-Yuan, Liu Wen-Xin, Hu Sen, Bu Zhi-Gao*,Identification and characterization of a virus-specific continuous B-cellepitope on the PrM/M protein of Japanese Encephalitis Virus: potentialapplication in the detection of antibodies to distinguish Japanese EncephalitisVirus infection from West Nile Virus and Dengue Virus infections, VirologyJournal, 2010,7(1):1-8.
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