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李苏楠,女,博士,助理研究员,重要人兽共患病与烈性外来病研究创新团队。
主要从事抗病毒天然免疫研究,对宿主限制因子Serinc5如何限制逆转录病毒MLV感染及相关机制进行了研究。
目前主持国家自然科学基金面上项目1项,青年基金1项;参与面上项目1项,青年基金2项。
以第一作者或者共同第一作者在Cell Reports、Journal of Virology、Journal of Biological Chemistry等杂志发表SCI文章13篇。
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支持扩展名:.rar .zip .doc .docx .pdf .jpg .png .jpeg1. 国家自然科学基金面上项目:内质网I型甘露糖苷酶(ERManⅠ)通过调节Spike蛋白成熟影响SARS2-CoV-2感染的机制(32172836,2011.01-2025.12),58万,在研,主持
2.国家青年基金项目:SERINC5限制逆转录病毒MLV感染性分子机制的研究(31700138,2018.01-2020.12),24万,在研,主持;
3.国家青年基金项目:牛SERINC5与牛白血病病毒细胞-细胞接触感染的相关性研究(31702270,2018.01-2020.12),26万,在研,参与。
4.国家青年基金项目,1602020,GPR109A在奶牛乳腺上皮细胞炎症反应中的作用及其分子机制,2017/01-2019/12,21万,在研,参加。
5.国家自然科学基金面上项目,31572479,GPR109A介导的猪肠上皮屏障功能调控的分子机制,2016/01-2019/12,64万,在研,参加。
1.Qingqing Chai#, Sunan Li#, Morgan K. Collins#, Rongrong Li, Iqbal Ahmad, Silas F. Johnson, Dylan A. Frabutt, Zhichang Yang, Xiaojing Shen, Liangliang Sun, Jian Hu, Judd F. Hultquist, B. Matija Peterlin, and Yong-Hui Zheng.HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize SERINC5 for optimal viral infectivity. Cell Rep. 2021, 36(6):109514.
2.Changqing Yu, Sunan Li, Xianfeng Zhang, Ilyas Khan, Iqbal Ahmad, Yulong Zhou, Shuo Li, Jing Shi, Yu Wang, Yong-Hui Zheng. MARCH8 Inhibits Ebola Virus Glycoprotein, Human Immunodeficiency Virus Type 1 Envelope Glycoprotein, and Avian Influenza Virus H5N1 Hemagglutinin Maturation.mBio. 2020, 11(5):e01882-20.
3.Ahmad I, Li S, Li R, Chai Q, Zhang L, Wang B, Yu C, Zheng YH. (2019). The retroviral accessory proteins S2, Nef, and glycoMA use similar mechanisms for antagonizing the host restriction factor SERINC5. Journal of Biological Chemistry 294(17):7013-7024.
4.Li S, Ahmad I, Shi J, Wang B, Yu C, Wang B, Zhang L, and Zheng YH. (2019). Murine Leukemia Virus Glycosylated Gag Reduces Murine SERINC5 Protein Expression at Steady-State Levels via the Endosome/Lysosome Pathway to Counteract SERINC5 Antiretroviral Activity. Journal of Virology 93(2):e01651-18.
5.Shi J, Xiong R, Zhou T, Su P, Zhang X, Qiu X, Li H, Li S, Yu C, Wang B, Ding C, Smithgall TE, and Zheng YH. (2018). HIV-1 Nef Antagonizes SERINC5 Restriction by Downregulation of SERINC5 via the Endosome/Lysosome System. Journal of Virology 92: e00196-18
6.Zhang X, Zhou T, Yang J, Lin Y, Shi J, Zhang X, Frabutt DA, Zeng X, Li S, Venta PJ, Zheng YH. (2017). Identification of SERINC5-001 as the Predominant Spliced Isoform for HIV-1 Restriction. Journal of Virology 91: e00137-17.
7.Sunan Li, Juxiong Liu, Qingkang Lv, Chuan Zhang, Shiyao Xu, Dongxue Yang, Bingxu Huang, Yalong Zeng, Yingjie Gao, Wei Wang*. AG and UAG induce β-casein expression via activation of ERK1/2 and AKT pathways[J] Journal of Molecular Endocrinology, 2016, 56 (3): 213-25. 2016 Apr
8.Nan Li#, Bowen Liu#, Wenzhi Ren#, Juxiong Liu#, Sunan Li#, Shoupeng Fu, Yalong Zeng, Shiyao Xu, Xuan Yan, Yingjie Gao, Dianfeng Liu, Wei Wang*. GLP-2 Attenuates LPS-Induced Inflammation in BV-2 Cells by Inhibiting ERK1/2, JNK1/2 and NF-κB Signaling Pathways[J]. Int J Mol Sci, 2016, 17(2): 1-11. 2016 Feb 4
9.Qingkang Lv#, Juxiong Liu#, Sunan Li#, Yingjie Gao#, Yan Lv#, Zipeng Xu, Bingxu Huang, Shiyao Xu, Dongxue Yang, Yalong Zeng, Dianfeng Liu, Wei Wang*. Mycophenolate Mofetil Modulates Differentiation of Th1/Th2 and the Secretion of Cytokines in an Active Crohn's Disease Mouse Model[J]. Int J Mol Sci, 2015, 16(11):26654-26666.
10.Shoupeng Fu#, Sunan Li#, Jianfa Wang#, Yang Li#, Shanshan Xie, Wenjing Xue, Hongmei Liu, Bingxu Huang, Qingkang Lv, Liancheng Lei, Guowen Liu, Wei Wang*, Juxiong Liu*. BHBA suppresses LPS-induced inflammation in BV-2 cells by inhibiting NF-κB activation[J]. Mediators of Inflammation, 2014; 2014: 983401.
11.Sunan Li#, Wei Wang#, Shoupeng Fu#, Jianfa Wang#, Hongmei Liu, Shanshan Xie, Bingrun Liu, Yang Li, Qingkang Lv, Zhiqiang Li, Wenjing Xue, Bingxu Huang, Wei Chen*, Juxiong Liu*. IL-21 modulates release of proinfla- mmatory cytokines in LPS-stimulated macrophages through distinct signaling pathways[J]. Mediators of Inflammation, 2013, Article ID 548073.
12.Jianfa Wang#, Shoupeng Fu#, Sunan Li#, Zhanqing Yang, Wenjing Xue, Zhiqiang Li, Wei Wang*, Juxiong Liu*. Establishment and characterization of dairy cow growth hormone secreting anterior pituitary cell model[J]. In Vitro Cell Dev Biol Animal, 2014, 50:103-110.
13.Jianfa Wang#, Shoupeng Fu#, Sunan Li#, Zhongming Hu, Wenjing Xue, Zhiqiang Li, Bingxu Huang, Qingkang Lv, Juxiong Liu*, Wang W*. Short-chain fatty acids inhibit growth hormone and prolactin gene transcription via cAMP/PKA/CREB signaling pathway in dairy cow anterior pituitary cells[J]. International Journal of Molecular Sciences, 2013, 14(11): 21474-21488.
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