李雁冰

所在单位及职称: 中国农业科学院哈尔滨兽医研究所，动物流感基础与防控研究创新团队，研究员。

受教育经历

2005/09-2008/07，中国农业科学院研究生院，博士研究生，导师：陈化兰

2000/09-2004/01，东北农业大学动物医学院，硕士研究生，导师：刘保全

1989/09-1994/07，南京农业大学兽医系，本科，侯加法

研究工作经历

2013/01-      ， 中国农业科学院哈尔滨兽医研究所，研究员

2012/04-2013/08，美国农业部东南家禽研究所，访问学者/博士后

2006/01-2012/12，中国农业科学院哈尔滨兽医研究所，副研究员

2001/01-2005/12，中国农业科学院哈尔滨兽医研究所，助理研究员

1994/07-2000/12，中国农业科学院哈尔滨兽医研究所，研究实习员

联系方式

邮箱：liyanbing@caas.cn, yanbingli@aliyun.com

电话：0451-51051676

发表论文：80余篇，其中SCI收录近60篇，第一或通讯作者近20篇

1. Cui Y, Li M, Li Y, Zhao L, ......, Li Y*, Chen H*. Evolution and extensive reassortment of H5 influenza viruses isolated from wild birds in China over the past decade, Emerg Microbes and Infections, 2020, https://doi.org/10.1080/22221751.2020.1797542.

 2. Li Y*, Li M, Li Y, Tian J, Bai X, Ai R, Chen W, Li J, Yang C, Kong Y, Guan Y, Chen H. H5N6 highly pathogenic avian influenza virus, subclade 2.3.4.4h, caused outbreaks in swans in Xinjiang, Emerging Infectious diseases. 2020, doi: 10.3201/eid2612.201201.

 3. Li X, Sun J, Lv X, Wang Y, Li Y, Li M, Liu W, Zhi M, Yang X, Fu T, Ma P, Li Y, Zhou X, Li Y, Yang G, Chen G, Zhang J, Zheng H, Zhang G, Hua Y, Yang S, Li Y*, Richt JA, Chai H. Novel Reassortant Avian Influenza A(H9N2) Virus Isolate in Migratory Waterfowl in Hubei Province, China. Front Microbiol. 2020 Feb 13;11:220. doi: 10.3389/fmicb.2020.00220. PMID:32117193.

 4. Sun J, Zhao L, Li X, Meng W, Chu D, Yang X, Peng P, Zhi M, Qin S, Fu T, Li J, Lu S, Wang W, He X, Yu M, Lv X, Ma W, Liao M, Liu Z, Zhang G, Wang Y, Li Y*, Chai H, Lu J, Hua Y. Novel H5N6 avian influenza virus reassortants with European H5N8 isolated in migratory birds, China. Transbound Emerg Dis. 2020 Mar;67(2):648-660. doi: 10.1111/tbed.13380. PMID: 31580519.

 5. Li Y, Li M, Tian J, Zhang Y, Bai X, Wang X, Shi J, Wang Y, Ma L, Yang C, Li Y*. Characteristics of the first H16N3 subtype influenza A viruses isolated in western China. Transbound Emerg Dis. 2020. Transbound Emerg Dis. 2020 Jul;67(4):1677-1687. doi: 0.1111/tbed.13511. PMID: 32266788.

 6. Yulei Li, Minghui Li, Jingman Tian, Xiaoli Bai, Yanbing Li*, Genetic characteristics and pathogenicity of novel reassortant H6 viruses isolated from wild birds in China, Vet Microbiol, 2021 Mar;254:108978. doi: 10.1016/j.vetmic.2021.108978. 

 7. Jingman Tian , Minghui Li , Xiaoli Bai , Yuelei Li, Xuefeng Wang, Fuhong Wang , Shi Jianzhong , Zeng Xianying, Tian Guobin , Yanbing Li*, H5 Low Pathogenic Avian Influenza Viruses Maintained in Wild Birds in China. Vet Microbiol, 2022, Accepted

8. Wang W, Sun X, Li Y*, Su J, Ling Z, Zhang T, Wang F, Zhang H, Chen H, Ding J, Sun B. Human antibody 3E1 targets the HA stem region of H1N1 and H5N6 influenza A viruses (2016) Nature Communications, 7,DOI: 0.1038/ncomms13577.

 9. Jin H, Wang D, Sun J, Cui Y, Chen G, Zhang X, Zhang J, Li X, Chai H, Gao Y, Li Y*, Hua Y. Pathogenesis and Phylogenetic Analyses of Two Avian Influenza H7N1 Viruses Isolated from Wild Birds. Front Microbiol. 2016 Jul 7;7:1066. doi: 10.3389/fmicb.2016.01066. PMID: 27458455.

 10. Fan Z, Ci Y, Liu L, Ma Y, Jia Y, Wang D, Guan Y, Tian G, Ma J, Li Y*, Chen H. Phylogenetic and pathogenic analyses of three H5N1 avian influenza viruses (clade 2.3.2.1) isolated from wild birds in Northeast China. Infect Genet Evol. 2015 Jan;29:138-45. doi: 10.1016/j.meegid.2014.11.020. PMID: 25461692.

 11. Fan Z, Ci Y, Ma Y, Liu L, Ma J, Li Y*, Chen H. Phylogenetic and pathogenic analysis of a novel H6N2 avian influenza virus isolated from a green peafowl in a wildlife park. Avian Dis. 2014 Dec;58(4):632-7. PubMed PMID: 25619010. 

 12. Fan Z, Ci Y, Ma Y, Liu L, Wang D, Ma J, Li Y*, Chen H. Phylogenetic analysis of a novel H6N6 avian influenza virus isolated from a green peafowl in China and its pathogenic potential in mice. Infect Genet Evol. 2014 Dec;28:107-12. doi: 10.1016/j.meegid.2014.09.008. PMID: 25220620.

 13. Li Y*, Shi J, Zhong G, Deng G, Tian G, Ge J, Zeng X, Song J, Zhao D, Liu L, Jiang Y, Guan Y, Bu Z, Chen H. Continued evolution of H5N1 influenza viruses in wild birds, domestic poultry, and humans in China from 2004 to 2009. J Virol. 2010 Sep;84(17):8389-97. doi: 10.1128/JVI.00413-10. PMID: 20538856.

 14. Li Y*, Liu L, Zhang Y, Duan Z, Tian G, Zeng X, Shi J, Zhang L, Chen H. New avian influenza virus (H5N1) in wild birds, Qinghai, China. Emerg Infect Dis. 2011 Feb;17(2):265-7. doi: 10.3201/eid1702.100732. PMID: 21291602.

 15. Li Y*, Li C, Liu L, Wang H, Wang C, Tian G, Webster RG, Yu K, Chen H. Characterization of an avian influenza virus of subtype H7N2 isolated from chickens in northern China. Virus Genes. 2006 Aug;33(1):117-22. PMID: 16791426.

16. Li Y*, Lin Z, Shi J, Qi Q, Deng G, Li Z, Wang X, Tian G, Chen H. Detection of Hong Kong 97-like H5N1 influenza viruses from eggs of Vietnamese waterfowl (2006) Archives of Virology, 151 (8), pp. 1615-1624.DOI: 10.1007/s00705-006-0738-7. 

 17. Li X, Lv X, Li Y, Peng P, Zhou R, Qin S, Ma E, Liu W, Fu T, Ma P, An Q, Li Y, Hua Y, Wang Y, Lei C, Chu D, Sun H, Li Y, Gao Y, Chai H. Highly Pathogenic Avian Influenza A(H5N8) Virus in Swans, China, 2020. Emerg Infect Dis. 2021 Jun;27(6):1732-1734. doi: 10.3201/eid2706.204727.

 18. Shi J, Deng G, Ma S, Zeng X, Yin X, Li M, Zhang B, Cui P, Chen Y, Yang H, Wan X, Liu L, Chen P, Jiang Y, Guan Y, Liu J, Gu W, Han S, Song Y, Liang L, Qu Z, Hou Y, Wang X, Bao H, Tian G, Li Y, Jiang L, Li C, Chen H. Rapid Evolution of H7N9 Highly Pathogenic Viruses that Emerged in China in 2017. Cell Host Microbe. 2018 Oct 10;24(4):558-568.e7. doi: 10.1016/j.chom.2018.08.006. PMID: 30269969.  

 19. Yin X, Deng G, Zeng X, Cui P, Hou Y, Liu Y, Fang J, Pan S, Wang D, Chen X, Zhang Y, Wang X, Tian G, Li Y, Chen Y, Liu L, Suzuki Y, Guan Y, Li C, Shi J, Chen H. Genetic and biological properties of H7N9 avian influenza viruses detected after application of the H7N9 poultry vaccine in China. PLoS Pathog. 2021 Apr 27;17(4):e1009561. doi: 10.1371/journal.ppat.1009561.PMID: 33905456 

 20. Shi J, Deng G, Kong H, Gu C, Ma S, Yin X, Zeng X, Cui P, Chen Y, Yang H, Wan X, Wang X, Liu L, Chen P, Jiang Y, Liu J, Guan Y, Suzuki Y, Li M, Qu Z, Guan L, Zang J, Gu W, Han S, Song Y, Hu Y, Wang Z, Gu L, Yang W, Liang L, Bao H, Tian G, Li Y, Qiao C, Jiang L, Li C, Bu Z, Chen H. H7N9 virulent mutants detected in chickens in China pose an increased threat to humans. Cell Res. 2017 Dec;27(12):1409-1421. doi: 10.1038/cr.2017.129. PMID:29151586. 

 21. Zeng X, Chen X, Ma S, Wu J, Bao H, Pan S, Liu Y, Deng G, Shi J, Chen P, Jiang Y, Li Y, Hu J, Lu T, Mao Sheng, Guo X, Liu J, Tian G, Chen H. Protective efficacy of an H5/H7 trivalent inactivated vaccine produced from Re-11, Re-12, and H7-Re2 strains against challenge with different H5 and H7 viruses in chickens. J Integ Agri. 2020, 19(0): 2-8.

 22. Gu C, Zeng X, Song Y, Li Y, Liu L, Kawaoka Y, Zhao D, Chen H. Glycosylation and an amino acid insertion in the head of hemagglutinin independently affect the antigenic properties of H5N1 avian influenza viruses. Sci China Life Sci. 2019 Jan;62(1):76-83. doi: 10.1007/s11427-018-9439-0. PMID: 30515728. 

 23. Li X, Shi J, Guo J, Deng G, Zhang Q, Wang J, He X, Wang K, Chen J, Li Y, Fan J, Kong H, Gu C, Guan Y, Suzuki Y, Kawaoka Y, Liu L, Jiang Y, Tian G, Li Y, Bu Z, Chen H. Genetics, receptor binding property, and transmissibility in mammals of naturally isolated H9N2 Avian Influenza viruses. PLoS Pathog. 2014 Nov 20;10(11):e1004508. doi: 10.1371/journal.ppat.1004508. PMID: 25411973. 

 24. Xu X, Bao H, Ma Y, Sun J, Zhao Y, Wang Y, Shi J, Zeng X, Li Y, Wang X, Chen H. Simultaneous detection of novel H7N9 and other influenza A viruses in poultry by multiplex real-time RT-PCR. Virol J. 2015 Apr 30;12:69. doi:10.1186/s12985-015-0300-x. PMID: 25925390.

 25. Li S, Meng W, Liu D, Yang Q, Chen L, Dai Q, Ma T, Gao R, Ru W, Li Y, Yu P, Lu J, Zhang G, Tian H, Chai H, Li Y. Migratory Whooper Swans Cygnus cygnus Transmit H5N1 Virus between China and Mongolia: Combination Evidence from Satellite Tracking and Phylogenetics Analysis. Sci Rep. 2018 May 4;8(1):7049. doi: 10.1038/s41598-018-25291-1.PMID: 29728621. 

 26. Song J, Xu J, Shi J, Li Y, Chen H. Synergistic Effect of S224P and N383D Substitutions in the PA of H5N1 Avian Influenza Virus Contributes to Mammalian Adaptation. Sci Rep. 2015 May 22;5:10510. doi: 10.1038/srep10510. PMID: 26000865. 

 27. Chen P, Ding L, Jiang Y, Zeng X, Deng G, Shi J, Li Y, Liu L, Zhao Y, Hu Y, Liu J, Chen H. Protective efficacy in farmed ducks of a duck enteritis virus-vectored vaccine against H5N1, H5N6, and H5N8 avian influenza viruses. Vaccine. 2019 Sep 20;37(40):5925-5929. doi: 10.1016/j.vaccine.2019.08.026. PMID: 31471151. 

 28. Zhao D, Liang L, Wang S, Nakao T, Li Y, Liu L, Guan Y, Fukuyama S, Bu Z, Kawaoka Y, Chen H. Glycosylation of the Hemagglutinin Protein of H5N1 Influenza Virus Increases Its Virulence in Mice by Exacerbating the Host Immune Response. J Virol. 2017 Mar 13;91(7). pii: e02215-16. doi: 10.1128/JVI.02215-16. PMID: 28100622.

 29. Liu L, Zeng X, Chen P, Deng G, Li Y, Shi J, Gu C, Kong H, Suzuki Y, Jiang Y, Tian G, Chen H. Characterization of Clade 7.2 H5 Avian Influenza Viruses That Continue To Circulate in Chickens in China. J Virol. 2016 Oct 14;90(21):9797-9805. doi: 10.1128/JVI.00855-16. PMID: 27558424.

 30. Wang W, Sun X, Li Y, Su J, Ling Z, Zhang T, Wang F, Zhang H, Chen H, Ding J, Sun B. Human antibody 3E1 targets the HA stem region of H1N1 and H5N6 influenza A viruses. Nat Commun. 2016 Dec 2;7:13577. doi: 10.1038/ncomms13577. PMID: 27910950.

 31. Yu Z, Gao X, Wang T, Li Y, Li Y, Xu Y, Chu D, Sun H, Wu C, Li S, Wang H, Li Y, Xia Z, Lin W, Qian J, Chen H, Xia X, Gao Y. Fatal H5N6 Avian Influenza Virus Infection in a Domestic Cat and Wild Birds in China. Sci Rep. 2015 Jun 2;5:10704. doi: 10.1038/srep10704. PMID: 26034886.

 32. Zeng X, Chen P, Liu L, Deng G, Li Y, Shi J, Kong H, Feng H, Bai J, Li X, Shi W, Tian G, Chen H. Protective Efficacy of an H5N1 Inactivated Vaccine Against Challenge with Lethal H5N1, H5N2, H5N6, and H5N8 Influenza Viruses in Chickens. Avian Dis. 2016 May;60(1 Suppl):253-5. doi: 10.1637/11179-052015-ResNoteR. PMID: 27309064.

 33. Li Z, Chen H, Jiao P, Deng G, Tian G, Li Y, Hoffmann E, Webster RG, Matsuoka Y, Yu K. Molecular basis of replication of duck H5N1 influenza viruses in a mammalian mouse model. J Virol. 2005 Sep;79(18):12058-64. PMID: 16140781.

 34. Zeng X, Deng G, Liu L, Li Y, Shi J, Chen P, Feng H, Liu J, Guo X, Mao S, Yang F, Chen Z, Tian G, Chen H. Protective Efficacy of the Inactivated H5N1 Influenza Vaccine Re-6 Against Different Clades of H5N1 Viruses Isolated in China and the Democratic People's Republic of Korea. Avian Dis. 2016 May;60(1 Suppl):238-40. doi: 10.1637/11178-051915-ResNote. PMID: 27309061.

 35. Liang L, Deng G, Shi J, Wang S, Zhang Q, Kong H, Gu C, Guan Y, Suzuki Y, Li Y, Jiang Y, Tian G, Liu L, Li C, Chen H. Genetics, Receptor Binding, Replication, and Mammalian Transmission of H4 Avian Influenza Viruses Isolated from Live Poultry Markets in China. J Virol. 2015 Nov 18;90(3):1455-69. doi: 10.1128/JVI.02692-15. PMID: 26581996.

 36. Li X, Shi J, Guo J, Deng G, Zhang Q, Wang J, He X, Wang K, Chen J, Li Y, Fan J, Kong H, Gu C, Guan Y, Suzuki Y, Kawaoka Y, Liu L, Jiang Y, Tian G, Li Y, Bu Z, Chen H. Correction: Genetics, Receptor Binding Property, and Transmissibility in Mammals of Naturally Isolated H9N2 Avian Influenza Viruses. PLoS Pathog. 2020 Jan 8;16(1):e1008284. doi: 10.1371/journal.ppat.1008284.  PMID: 31914139.

 37. Zhao D, Liang L, Li Y, Jiang Y, Liu L, Chen H. Phylogenetic and pathogenic analyses of avian influenza A H5N1 viruses isolated from poultry in Vietnam. PLoS One. 2012;7(11):e50959. doi: 10.1371/journal.pone.0050959. PMID: 23226433.

 38. Bao H, Wang X, Zhao Y, Sun X, Li Y, Xiong Y, Chen H. Development of a reverse transcription loop-mediated isothermal amplification method for the rapid detection of avian influenza virus subtype H7. J Virol Methods. 2012 Jan;179(1):33-7. doi: 10.1016/j.jviromet.2011.08.023. PMID: 21930158.

 39. Shan S, Jiang Y, Bu Z, Ellis T, Zeng X, Edwards J, Tian G, Li Y, Ge J, Chen H, Fenwick S. Strategies for improving the efficacy of a H6 subtype avian influenza DNA vaccine in chickens. J Virol Methods. 2011 May;173(2):220-6. doi: 10.1016/j.jviromet.2011.02.008. PMID: 21333689.

 40. Jiao P, Tian G, Li Y, Deng G, Jiang Y, Liu C, Liu W, Bu Z, Kawaoka Y, Chen H. A single-amino-acid substitution in the NS1 protein changes the pathogenicity of H5N1 avian influenza viruses in mice. J Virol. 2008 Feb;82(3):1146-54. Epub 2007 Nov 21. PMID: 18032512.

 41. Li C, Ping J, Jing B, Deng G, Jiang Y, Li Y, Tian G, Yu K, Bu Z, Chen H. H5N1 influenza marker vaccine for serological differentiation between vaccinated and infected chickens. Biochem Biophys Res Commun. 2008 Jul 25;372(2):293-7. doi: 10.1016/j.bbrc.2008.05.057. PMID: 18501701.

 42. Ge J, Deng G, Wen Z, Tian G, Wang Y, Shi J, Wang X, Li Y, Hu S, Jiang Y, Yang C, Yu K, Bu Z, Chen H. Newcastle disease virus-based live attenuated vaccine completely protects chickens and mice from lethal challenge of homologous and heterologous H5N1 avian influenza viruses. J Virol. 2007 Jan;81(1):150-8. PMID: 17050610.

 43. Zhao D, Liang L, Li Y, Liu L, Guan Y, Jiang Y, Chen H. Proteomic analysis of the lungs of mice infected with different pathotypes of H5N1 avian influenza viruses. Proteomics. 2012 Jun;12(12):1970-82. doi: 10.1002/pmic.201100619. PMID: 22623221.

 44. Song J, Feng H, Xu J, Zhao D, Shi J, Li Y, Deng G, Jiang Y, Li X, Zhu P, Guan Y, Bu Z, Kawaoka Y, Chen H. The PA protein directly contributes to the virulence of H5N1 avian influenza viruses in domestic ducks. J Virol. 2011 Mar;85(5):2180-8. doi: 10.1128/JVI.01975-10. PMID:21177821.

 45. Tian G, Zeng X, Li Y, Shi J, Chen H. Protective efficacy of the H5 inactivated vaccine against different highly pathogenic H5N1 avian influenza viruses isolated in China and Vietnam. Avian Dis. 2010 Mar;54(1 Suppl):287-9. PMID: 20521646.

 46. Jiang Y, Yu K, Zhang H, Zhang P, Li C, Tian G, Li Y, Wang X, Ge J, Bu Z, Chen H. Enhanced protective efficacy of H5 subtype avian influenza DNA vaccine with codon optimized HA gene in a pCAGGS plasmid vector. Antiviral Res. 2007 Sep;75(3):234-41. PMID: 17451817.

 47. Gao Y, Zhang Y, Shinya K, Deng G, Jiang Y, Li Z, Guan Y, Tian G, Li Y, Shi J, Liu L, Zeng X, Bu Z, Xia X, Kawaoka Y, Chen H. Identification of amino acids in HA and PB2 critical for the transmission of H5N1 avian influenza viruses in a mammalian host. PLoS Pathog. 2009 Dec;5(12):e1000709. doi:10.1371/journal.ppat.1000709. PMID: 20041223.

 48. Qiao C, Tian G, Jiang Y, Li Y, Shi J, Yu K, Chen H. Vaccines developed for H5 highly pathogenic avian influenza in China. Ann N Y Acad Sci. 2006 Oct;1081:182-92. PMID: 17135510.

 49. Tian G, Zhang S, Li Y, Bu Z, Liu P, Zhou J, Li C, Shi J, Yu K, Chen H. Protective efficacy in chickens, geese and ducks of an H5N1-inactivated vaccine developed by reverse genetics. Virology. 2005 Oct 10;341(1):153-62. PMID: 16084554.

 50. Fan S, Gao Y, Shinya K, Li C, Li Y, Shi J, Jiang Y, Suo Y, Tong T, Zhong G, Song J, Zhang Y, Tian G, Guan Y, Xu XN, Bu Z, Kawaoka Y, Chen H. Immunogenicity and protective efficacy of a live attenuated H5N1 vaccine in nonhuman primates. PLoS Pathog. 2009 May;5(5):e1000409. doi: 10.1371/journal.ppat.1000409. PMID: 19412338.

 51. Jia B, Shi J, Li Y, Shinya K, Muramoto Y, Zeng X, Tian G, Kawaoka Y, Chen H. Pathogenicity of Chinese H5N1 highly pathogenic avian influenza viruses in pigeons. Arch Virol. 2008;153(10):1821-6. doi: 10.1007/s00705-008-0193-8. PMID: 18779923.

 52. Chen Y, Zhong G, Wang G, Deng G, Li Y, Shi J, Zhang Z, Guan Y, Jiang Y, Bu Z, Kawaoka Y, Chen H. Dogs are highly susceptible to H5N1 avian influenza virus. Virology. 2010 Sep 15;405(1):15-9. doi: 10.1016/j.virol.2010.05.024. PMID: 20580396.

 53. Chen H, Li Y, Li Z, Shi J, Shinya K, Deng G, Qi Q, Tian G, Fan S, Zhao H, Sun Y, Kawaoka Y. Properties and dissemination of H5N1 viruses isolated during an influenza outbreak in migratory waterfowl in western China. J Virol. 2006 Jun;80(12):5976-83. PMID: 16731936.

 54. Wang X, Shi L, Tao Q, Bao H, Wu J, Cai D, Wang F, Zhao Y, Tian G, Li Y, Qao C, Chen H. A protein chip designed to differentiate visually antibodies in chickens which were infected by four different viruses. J Virol Methods. 2010 Aug;167(2):119-24. doi: 10.1016/j.jviromet.2010.03.021. PMID: 20362004.

 55. Tao Q, Wang X, Bao H, Wu J, Shi L, Li Y, Qiao C, Yakovlevich SA, Mikhaylovna PN, Chen H. Detection and differentiation of four poultry diseases using asymmetric reverse transcription polymerase chain reaction in combination with oligonucleotide microarrays. J Vet Diagn Invest. 2009 Sep;21(5):623-32. PMID: 19737757.

 56. Li J, Jiang Y, Zhao S, Chang X, Liu J, Zeng X, Li Y, Chen H. Protective efficacy of an H5N1 DNA vaccine against challenge with a lethal H5N1 virus in quail. Avian Dis. 2012 Dec;56(4 Suppl):937-9. PMID: 23402115. 

 57. Zhang H, Meng L, Gao Y, Zhang Y, Niu L, Yu Z, Li Y, Guan T, Sun X, Zhao H. Changes in methylation of genomic DNA from chicken immune organs in response to H5N1 influenza virus infection (2016) Genetics and Molecular Research, 15 (3),DOI: 10.4238/gmr.15037382.