中国农业科学院哈尔滨兽医研究所动物流感基础与防控研究创新团队，是我国从事动物流感基础和应用研究最具影响力的团队，同时也具有广泛国际影响力。团队现有109名科研及辅助人员，包括科学院院士1人、研究员13人、副研究员5人。在首席科学家陈化兰院士的带领下，该团队在动物流感基础研究方面取得若干重要发现，先后在Science等国内外学术刊物发表研究论文300余篇。这些研究发现深化了对动物流感病毒的科学认知，为动物及人类新发流感的预警、防治策略的制定实施及相关防控技术研发，提供了理论依据。创制的多个具有国际先进技术水平的禽流感疫苗，在国内外累计生产应用2800多亿剂量，为高致病力禽流感的有效防控发挥了重要作用，创造了巨大社会和经济效益。并先后获得国家科技进步一等奖1项，国家技术发明二等奖1项，国家自然科学二等奖2项和多个省部级科技奖项。

1. 十三五重点研发计划课题“中埃禽流感综合防控技术联合研究与技术示范应用” (2020年-2022年)，100万元，主持；

2. 国家自然科学基金面上项目“H5亚型禽流感病毒同义HA的设计及其免疫特性研究 ”(2017年-2020年)，62万元，主持；

3. 十三五国家重点研发计划“鸡重要疫病免疫防控新技术研究”子课题，54.6万元，主持；

4. 国家自然科学青年基金 “Clade7.2 H5N1亚型禽流感病毒抗原性变异分子机制研究(2014年-2016年)”，23万元，主持；

5. 黑龙江省自然科学青年基金 “禽流感H5N2亚型7.2分支病毒遗传变异分析及防控疫苗研究（2014年-2016年）”，5万元，主持。

获得新兽药证书：

1. 重组禽流感病毒(H5+H7)三价灭活疫苗(细胞源，H5N1 Re-11株+Re-12株，H7N9 H7-Re2株)，三类，（2021）新兽药证字52号

2. 重组禽流感病毒（H5+H7）二价灭活疫苗（H5N1 Re-8株+H7N9 H7-Re1株），一类， (2019)新兽药证字37号

3. 鸡新城疫、禽流感（H9亚型）、减蛋综合征三联灭活疫苗（La Sota株+Re-9株+京911株），三类，（2019）新兽药证字

4. 重组禽流感病毒H5亚型灭活疫苗（H5N1，Re-6株，细胞源），三类，2018)新兽药证字25号

发表SCI论文：

1.       X. Yin#,G. Deng#, X. Zeng# (共同第一), P. Cui, Y. Hou, Y. liu, J. Fang, S. Pan, D. Wang, X. Chen, Y. Zhang, X. Wang, G. Tian, Y. Li, Y.Chen, L. Liu, Y. Suzuki, Y. Guan, C. Li, J. Shi*, H. Chen*(2021).Genetic and biological properties of H7N9 avian influenza viruses detectedafter application of the H7N9 poultry vaccine in China. PLoS Pathogens, 17(4):e1009561.

2.       X.Zeng, X. Chen, S. Ma, J.Wu, H. Bao, S Pan, Y. Liu, G. Deng, J. Shi, P. Chen, Y. Jiang, Y. Li, J. Hu, L.Tong, S. Mao, X. Guo, J. Liu, G. Tian*, H. Chen*. (2020). Protectiveefficacy of an H5/H7 trivalent inactivated vaccine produced from Re-11, Re-12,and H7-Re2 strains against challenge with different H5 and H7 viruses inchickens. Journal of Integrative Agriculture, 19(9): 2294–2300

3.       C. Gu,X. Zeng, Y. Song, Y. Li, L. Liu, Y. Kawaoka, D. Zhao*, H. Chen*（2019）.Glycosylation and an aminoacid insertion in the head of hemagglutinin independently affect the antigenicproperties of H5N1 avian influenza viruses. Science China Life Sciences, 62(1),76-83

4.       J. Shi#,G. Deng#, S. Ma#, X. Zeng, X#（共同第一）. Yin#, M. Li, B. Zhang, P. Cui, Y. Chen, H.Yang, X. Wan, L. Liu, P. Chen, Y. Jiang, Y. Guan, J. Liu, W. Gu, S. Han, Y.Song, L. Liang, Z. Qu, Y. Hou, X. Wang, H. Bao, G. Tian, Y. Li, L. Jiang, C.Li, H. Chen*(2018). Rapid evolution of H7N9 highly pathogenic viruses thatemerged in China in 2017. Cell Host& Microbe 24, 558-568

5.       ZengX, Tian G, Shi J, Deng G,Li C, Chen H. (2018). Vaccination of poultry successfully eliminatedhuman infection with H7N9 virus in China. Sci China Life Scidoi:10.1007/s11427-018-9420-1.

6.       Liu L,Zeng X (共同第一), Chen P, Deng G, Li Y, Shi J, Gu C, KongH, Suzuki Y, Jiang Y, Tian G, Chen H. (2016). Characterization of Clade7.2 H5 Avian Influenza Viruses That Continue to Circulate in Chickens in China.J Virol doi:10.1128/JVI.00855-16.

7.       Xianying Zeng, Pucheng Chen, Liling Liu, Guohua Deng, Yanbing Li,Jianzhong Shi, Huihui Kong, Huapeng Feng, Jie Bai, Xin Li, Wenjun Shi, GuobinTian, and Hualan Chen (2016)Protective Efficacy of an H5N1 Inactivated Vaccine against Challenge withLethal H5N1, H5N2, H5N6, and H5N8 Influenza Viruses in Chickens. Avian Diseases,2016;60:253-5.

8.       Xianying Zeng, Guohua Deng, Liling Liu, Yanbing Li, Jianzhong Shi,Pucheng Chen, Huapeng Feng, Jingli Liu, Xingfu Guo, Shenggang Mao, Fan Yang,Zhiyu Chen, Guobin Tian, and Hualan Chen (2015)Protective Efficacy of the Inactivated H5N1 Influenza Vaccine Re-6 againstDifferent Clades of H5N1 Viruses Isolated in China and the Democratic People'sRepublic of Korea. Avian Diseases, 2016;60:238-40.

9.       Bao,Hongmei，Ma, Yong，Shi,Jianzhong，Zhao,Yuhui，Zeng, Xianying, Wang, Xiurong，Chen,Hualan*(2015)，Evaluation and application of a one-step duplexreal-time reverse transcription polymerase chain reaction assay for the rapiddetection of influenza A (H7N9) virus from poultry samples，Archives ofvirology，160（10）：2471-2477。

10.   Wen,Xuexia ，Sun, Jiashan，Wang,Xiurong ，Bao, Hongmei，ZhaoYuhui, Zeng, Xianying，Xu, Xiaolong，Ma, Yong，Gu, Linlin，Chen,Hualan*(2015)，Identification of a novel linear epitope onthe NS1 protein of avian influenza virus.，BMCMicrobiology，15：168-168。

11.   Xu,Xiaolong ，Bao, Hongmei，Ma, Yong，Sun, Jiashan，Zhao,Yuhui,Wang, Yunhe，Shi, Jianzhong，Zeng, Xianying，Li, Yanbing，Wang,Xiurong(*)，Chen, Hualan(*)，Simultaneous detection of novel H7N9 and otherinfluenza A viruses in poultry by multiplex real-time RT-PCR.，Virology Journal，2015，12：69-69。

12.   Shi J.,G. Deng, X. Zeng, H. Kong, X. Wang,K. Lu, X. Wang, G. Mu, X. Xu, P. Cui, H. Bao, G. Tian, H. Chen* (2014). Novel Influenza A(H7N2) Virus in Chickens,Jilin Province, China, 2014. Emerging Infectious Disease, 20 (10):1719-1722

13.   Bao,H., Y. Zhao, Y. Wang, X. Xu, J. Shi, X.Zeng, X. Wang, and H. Chen (2014).Development of a reverse transcription loop-mediated isothermal amplificationmethod for the rapid detection of subtype H7N9 avian influenza virus. BioMed research international2014:525064.

14.   ZhangQ., J. Shi, G. Deng, J. Guo, X. Zeng(co-first author), X. He, H. Kong, C. Gu, X. Li, J. Liu, G.Wang, Y. Chen, L. Liu, L. Liang, Y. Li, J. Fan, J. Wang, W. Li, L. Guan, Q. Li,H. Yang, P. Chen, L. Jiang, Y. Guan, X. Xin, Y. Jiang, G. Tian, X. Wang, C.Qiao, C. Li, Z. Bu, H. Chen*(2013). H7N9 influenza viruses aretransmissible in ferrets by respiratory droplet. Science 341, 410-414.

15.   Li,J., Y. Jiang, S. Zhao, X. Chang, J. Liu, X.Zeng, Y. Li, and H. Chen (2012).Protective efficacy of an H5N1 DNA vaccine against challenge with a lethal H5N1virus in quail. Avian Dis56:937-939.

16.   Liu,J., P. Chen, Y. Jiang, L. Wu, X. Zeng,G. Tian, J. Ge, Y. Kawaoka, Z. Bu, and H. Chen (2011). A duck enteritis virus-vectored bivalent live vaccineprovides fast and complete protection against H5N1 avian influenza virusinfection in ducks. J Virol85:10989-10998.

17.   Li,Y., L. Liu, Y. Zhang, Z. Duan, G. Tian, X.Zeng, J. Shi, L. Zhang, and H. Chen (2011). New avian influenza virus(H5N1) in wild birds, Qinghai, China. EmergInfect Dis 17:265-267.

18.   Tian,G., X. Zeng(co-first authors), Y. Li, J. Shi,and H. Chen* (2010). Protective efficacy of the H5 inactivated vaccine againstdifferent highly pathogenic H5N1 avian influenza viruses isolated in China andVietnam. Avian Dis 54:287-289.

19.   Li,Y., J. Shi, G. Zhong, G. Deng, G. Tian, J. Ge, X. Zeng, J. Song, D. Zhao, L. Liu, Y. Jiang, Y. Guan, Z. Bu, and H.Chen (2010). Continued evolution ofH5N1 influenza viruses in wild birds, domestic poultry, and humans in Chinafrom 2004 to 2009. J Virol84:8389-8397.

20.   Ge,J., G. Tian, X. Zeng, Y. Jiang, H.Chen, and Z. Bu* (2010).a Generationand evaluation of a Newcastle disease virus-based H9 avian influenza livevaccine. Avian Dis 54:294-296.

21.     Gao, Y., Y. Zhang, K. Shinya, G. Deng, Y.Jiang, Z. Li, Y. Guan, G. Tian, Y. Li, J. Shi, L. Liu, X. Zeng, Z. Bu, X. Xia, Y. Kawaoka, and H. Chen (2009).Identification of amino acids inHA and PB2 critical for the transmission of H5N1 avian influenza viruses in amammalian host. PLoS Pathog5:e1000709.

22.     Jia, B., J. Shi, Y. Li, K. Shinya, Y.Muramoto, X. Zeng, G. Tian, Y.Kawaoka, and H. Chen (2008).Pathogenicity of Chinese H5N1 highly pathogenic avian influenza viruses inpigeons. Arch Virol 153:1821-1826.