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李呈军，博士生导师，中国农业科学院哈尔滨兽医研究所动物流感基础与防控研究创新团队研究员、科研管理与国际合作处处长，获得国家自然科学基金“优青”资助，入选国家级人才、中国农业科学院“农科英才B类”、“青年英才”等。2005年博士毕业于中国农业科学院研究生院，2005-2012年在美国威斯康星大学从事博士后和助理科学家研究。2000年以来，一直专注于流感病毒的基础和防控研究，以第一或通讯作者在NatureMicrobiology，PNAS，Protein& Cell，PLoSPathogens，mBio，Journalof Virology等杂志发表SCI论文20多篇。主持国家自然科学基金面上项目和黑龙江省自然科学基金“杰青”项目，是国家自然科学基金创新研究群体项目、“十三五”和“十四五”国家重点研发计划项目及黑龙江省兽医病毒学创新研究“头雁”团队学术骨干。目前，担任中国微生物学会病毒学专业委员会委员、VirologyJournal期刊流感栏目副主编和WHO流感大流行病毒评估专家。
(1)岭南现代农业科学与技术广东省实验室，NT2021007，新发/突发畜禽动物疫病的阻断技术研究，2021/10-2024/09，1500万元（本人可支配经费300万元），在研，子课题负责人；
(2)黑龙江省杰出青年科学基金，JQ2019C005，TRIM家族蛋白调控流感病毒复制机制研究，2019/07-2022/07，50万元，在研，主持；
(3)国家重点研发计划项目，2016YFD0500200，动物流感病毒遗传变异与致病机理研究，2016/07-2021/06，4200万元（本人可支配经费155万元），在研，参加；
(4)国家自然科学基金创新研究群体项目，31521005，动物流感病毒的进化及其与宿主互作机制，2016/01-2021/12，1200万元（本人可支配经费200万元），在研，参加；
(5)国家自然科学基金优秀青年科学基金，31422054，流感病毒感染与变异，2015/01-2017/12，100万元，已结题，主持；
(6)国家自然科学基金面上项目，31472215，流感病毒M2 蛋白与宿主蛋白的相互作用及其分子机制研究，2015/01-2018/12，79万元，已结题，主持；
(7)哈尔滨市优秀学科带头人项目，2014RFXYJ048，高生长特性H5N1禽流感疫苗株研制，2014/06-2016/06，7万元，已结题，主持；
(8)欧盟第七框架项目、FP7-613804、LinkingEpidemiology and Laboratory Research on Transboundary Animal Diseases andZoonoses in China and EU，2013/11-2016/10，100万欧元，已结题，参加；
(9)人事部留学回国人员科技活动择优资助项目，2013/10-2014/12，3万元，已结题，主持；
(10)中央级公益性科研院所基本科研业务费专项，0302013016，WNT/β-Catenin信号通路对流感病毒复制的调控机制研究，2013/01-2014/12，110万元，已结题，主持。
Zhao Y#, Wen X#, Li Q, Jiang L, Wang G, Liang L, Wang X, Chen H*, Li C*. 2021. Generation and application of two monoclonal antibodies targeting conserved linear epitopes in the NP protein of influenza A virus. Journal of Integrative Agriculture Doi: 10.1016/S2095-3119(21)63840-6.
Cui J, Cui P, Shi J, Fan W, Xing X, Gu W, Zhang Y, Zhang Y, Zeng X, Jiang Y, Chen P, Yang H, Chen Y, Liu J, Liu L, Tian G, Lu Y, Chen H, Li C*, Deng G*. 2021. Continued evolution of H6 avian influenza viruses isolated from farms in China between 2014 and 2018. Transboundary and Emerging Diseases doi: 10.1111/tbed.14212.
Li J#, Liang L#, Jiang L#, Wang Q, Wen X, Zhao Y, Cui P, Zhang Y, Wang G, Li Q, Deng G, Shi J, Tian G, Zeng X, Jiang Y, Liu L, Chen H*, Li C*. 2021. Viral RNA-binding ability conferred by SUMOylation at PB1 K612 of influenza A virus is essential for viral pathogenesis and transmission. PLoS Pathogens 17:e1009336.
Sun N#, Jiang L#, Ye M, Wang Y, Wang G, Wan X, Zhao Y, Wen X, Liang L, Ma S, Liu L, Bu Z, Chen H*, Li C*. 2020. TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2. Protein Cell 11: 894-914.
Li C, Chen H*. H7N9 Influenza Virus in China. 2020. Cold Spring Harbor Perspective Medicine pii: a038349.
Wang G, Jiang L, Wang J, Zhang J, Kong F, Li Q, Yan Y, Huang S, Zhao Y, Liang L, Li J, Sun N, Hu Y, Shi W, Deng G, Chen P, Liu L, Zeng X, Tian G, Bu Z, Chen H, Li C*. 2020. The G Protein-Coupled Receptor FFAR2 Promotes Internalization during Influenza A Virus Entry. Journal of Virology 94: e01707-19.
Liang L#, Jiang L#, Li J, Zhao Q, Wang J, He X, Huang S, Wang Q, Zhao Y, Wang G, Sun N, Deng G, Shi J, Tian G, Zeng X, Jiang Y, Liu L, Liu J, Chen P, Bu Z, Kawaoka Y*, Chen H*, Li C*. 2019. Low Polymerase Activity Attributed to PA Drives the Acquisition of the PB2 E627K Mutation of H7N9 Avian Influenza Virus in Mammals. mBio 10: e01162-19.
Luo W#, Zhang J#, Liang L, Wang G, Li Q, Zhu P, Zhou Y, Li J, Zhao Y, Sun N, Huang S, Zhou C, Chang Y, Cui P, Chen P, Jiang Y, Deng G, Bu Z, Li C*, Jiang L*, Chen H*. 2018. Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication. PLoS Pathogens 14: e1006851.
Wang, G, Zhang J, Kong F, Li Q, Wang J, Ma S, Zhao Y, Liang L, Li J, Sun N, Guan L, Zhou Y, Zhou C, Huang S, Bu Z, Chen H*, Li C*. 2018. Generation and application of replication-competent Venus-expressing H5N1, H7N9, and H9N2 influenza A viruses. Science Bulletin 63: 176-186.
Zhu P, Liang L, Shao X, Luo W, Jiang S, Zhao Q, Sun N, Zhao Y, Li J, Wang J, Zhou Y, Zhang J, Wang G, Jiang L, Chen H*, Li C*. 2017. Host cellular protein TRAPPC6A△ interacts with influenza A virus M2 protein and regulates viral propagation by modulating M2 trafficking. Journal of Virology 91: e01757-16.
Li C#, Hatta M#, Burke DF#, Ping J#, Zhang Y#, Ozawa M, Taft AS, Das SC, Hanson AP, Song J, Imai M, Wilker PR, Watanabe T, Watanabe S, Ito M, Iwatsuki-Horimoto K, Russell CA, James SL, Skepner E, Maher EA, Neumann G, Klimov AI, Kelso A, McCauley J, Wang D, Shu Y, Odagiri T, Tashiro M, Xu X, Wentworth DE, Katz JM, Cox NJ, Smith DJ*, Kawaoka Y*. 2016. Selection of antigenically advanced variants of seasonal influenza viruses. Nature Microbiology 1: 16058.
Wang X#, Gu L#, Shi J, Xu H, Zhang Y, Zeng X, Deng G, Li C*, Chen H*. 2017. Development of a real-time RT-PCR method for the detection of newly emerged highly pathogenic H7N9 influenza viruses. Journal of Integrative Agriculture 16: 2055-2061.
Liang L#, Deng G#, Shi J, Wang S, Zhang Q, Kong H, Gu C, Guan Y, Suzuki Y, Li Y, Jiang Y, Tian G, Liu L, Li C*, Chen H* 2015. Genetics, Receptor Binding, Replication, and Mammalian Transmission of H4 Avian Influenza Viruses Isolated from Live Poultry Markets in China. Journal of Virology 90: 1455-1469.
Li C, Chen H*. 2014. Enhancement of influenza virus transmission by gene reassortment. Current Topics in Microbiology and Immunology 385: 185-204.
Li C, Bu Z, Chen H*. 2014. Avian influenza vaccines against H5N1 'bird flu'. Trends in Biotechnology 32: 147-156.
Deng G#, Tan D#, Shi J, Cui P, Jiang Y, Liu L, Tian G, Kawaoka Y, Li C*, Chen H*. 2013. Complex reassortment of multiple subtypes of avian influenza viruses in domestic ducks at the Dongting Lake Region of China. Journal of Virology 87: 9452-9462.
Shi J#, Deng G#, Liu P, Zhou J, Guan L, Li W, Li X, Guo J, Wang G, Fan J, Wang J, Li Y, Jiang Y, Liu L, Tian G, Li C*, Chen H*. Isolation and characterization of H7N9 viruses from live poultry markets—Implication of the source of current H7N9 infection in humans. 2013, Chinese Science Bulletin 58: 1857-1863.
Li C#, Bankhead A 3rd#, Eisfeld AJ, Hatta Y, Jeng S, Chang JH, Aicher LD, Proll S, Ellis AL, Law GL, Waters KM, Neumann G, Katze MG*, McWeeney S*, Kawaoka Y*. 2011. Host regulatory network response to infection with highly pathogenic H5N1 avian influenza virus. Journal of Virology 85: 10955-67.
Li C#, Hatta M#, Nidom CA, Muramoto Y, Watanabe S, Neumann G, Kawaoka Y. 2010. Reassortment between avian H5N1 and human H3N2 influenza viruses creates hybrid viruses with substantial virulence. Proceedings of the National Academy of Sciences of the United States of America 107: 4687-4692.
Li C, Hatta M, Watanabe S, Neumann G, Kawaoka Y. 2008. Compatibility among polymerase subunit proteins is a restricting factor in the reassortment between equine H7N7 and human H3N2 viruses. Journal of Virology 82: 11880-11888.
Li C, Ping J, Jing B, Deng G, Jiang Y, Li Y, Tian G, Yu K, Bu Z, Chen H. 2008. H5N1 influenza marker vaccine for serological differentiation between vaccinated and infected chickens. Biochemical and Biophysical Research Communications 372: 293-297.
Li Y#, Li C#, Liu L, Wang H, Wang C, Tian G, Webster RG, Yu K, Chen H. 2006. Characterization of an avian influenza virus of subtype H7N2 isolated from chickens in northern China. Virus genes 33: 117-122.
Li C, Yu K, Tian G, Yu D, Liu L, Jing B, Ping J, Chen H. 2005. Evolution of H9N2 influenza viruses from domestic poultry in Mainland China. Virology 340: 70-83.
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