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郭永峰,男,1970年10月出生。美国康奈尔大学博士,密歇根大学博士后,中国农业科学院烟草研究所研究员,博士生导师,烟草功能基因组创新团队首席科学家,生物技术研究中心副主任。长期从事植物发育分子生物学领域研究,重点关注的研究方向包括:1)叶片衰老的分子生物学,2)植物多肽信号对发育过程调控的分子机制,3)植物生物反应器。先后主持国家自然科学基金面上项目、农业部948项目等科研项目10余项。在Molecular Plant、Plant Cell等杂志表论文70余篇,主编出版英文专著“Plant Senescence – Methods and Protocols”,同行引用3000余次。作为主要完成人获省部级科技进步三等奖2项,授权国际发明专利1项、国家发明专利11项。2004年获康奈尔大学Liu Memorial Award,2013年度人力资源和社会保障部高层次留学人才回国资助人选,2018年入选中国农业科学院农科英才领军人才(C类)。兼任国际烟草科学研究合作中心(CORESTA)科学委员会委员、农艺学组副主席、烟碱遗传学工作组负责人,Frontiers in Plant Science、中国烟草科学等学术期刊编委。中国植物生理与分子生物学学会开花成熟衰老专业委员会副主任,山东遗传学会、山东植物生理与分子生物学学会常务理事。
2021.5-2022.5 “烟草瞬时表达系统生产药用蛋白技术研究与应用”, 中央引导地方科技发展资金,自由探索类基础研究项目,300万元,主持
2021.1-2023.12 “烟草关键品质性状遗传解析与分子设计育种”,中国农业科学院科技创新工程所级重点任务,450万元,主持
2021.1-2022.12 “LRR蛋白激酶HAE/HSL2介导IDA多肽信号调控器官衰老与脱落的分子机制”,中国农业科学院烟草研究所国际合作基金,25.5万元,主持
2019.1-2023.12 “农科英才领军人才(C类)”,中国农业科学院人才项目资助,400万元,主持
2018.1-2020.12 “Tobacco Alkaloid Genetics”,CORESTA Task Force,主持
2017.1-2019.12 “CLAVATA途径对植物分生组织细胞分裂分化的分子调控机制”, 中国农业科学院基本科研业务费院级统筹项目,90万元,主持
2016.1-2019.12 “CLE多肽在拟南芥根端分生组织激活BAM1/BAM2受体蛋白的分子机制研究”,国际自然科学基金面上项目,73.2万元,主持
2013.7-2016.7 “高层次留学人才回国工作资助”, 人力资源与社会保障部, 30万元, 主持
2014.1-2014.12 “拟南芥CLE 多肽激素信号传导新因子克隆鉴定”, 中国农业科学院基本科研业务费增量项目, 40万元, 主持
2013.1-2013.12 “高通量植物衰老基因克隆技术(TASSEL-tagging系统)的引进、创新及利用”, 农业部948项目, 60万元, 主持
2013.1-2013.12 “烟草叶片衰老的分子调控机制研究”, 中国农业科学院基本科研业务费增量重点项目, 80万元, 主持
2012.1-2012.12 “烟草CLE基因TGIc104053功能分析”, 国家烟草专卖局创新平台项目, 50万元, 主持
代表性论文:
Zhang Z, Liu C, Li K, Li X, Xu M,and Guo Y* (2021) CLE14 functions asa “brake signal” suppressing age-dependent and stress-induced leaf senescencethrough promoting JUB1-mediated ROS scavenge in Arabidopsis. Molecular Plant doi: https://doi.org/10.1016/j.molp.2021.09.006.
Guo Y*,Hiatt E, Bonnet C, Kudithipudi D, Lewis RS, Shi H, Patra B, Zhao X, Dorlhac de BorneF, Gilles T, Yang S, Zhang H, Zhang M, Lusso M, Berger IJ, Xu D, Wen L (2021) Molecularregulation and genetic manipulation of alkaloid accumulation in tobacco plants.Studies in Natural Products Chemistry (Attaur, Rahman edited), Elsevier Vol. 70:119-149.
Guo Y#, Ren G#, Zhang K#, Li Z#, Miao Y*, Guo H* (2021) Leaf senescence: progression, regulation,and application. Molecular Horticulture1:5.
Wang Q#, Guo C#,Li Z, Sun J, Wang D, Xu L, Li X*, Guo Y*(2021) Identification and analysis of bZIP family genes in potato and their potentialroles in stress responses. Frontiers in PlantScience 12:637343.
Li L#, Li K#,Ali A, Guo Y* (2021) AtWAKL10, acell wall associated receptor-like kinase, negatively regulates leaf senescencein Arabidopsis thaliana. International Journal of Molecular Sciences 22(9):4885.
Li W, Wen L, Chen Z, Zhang Z,Pang X, Deng Z, Liu T, Guo Y* (2021)Study on metabolic variation in whole grains of four proso millet varietiesreveals metabolites important for antioxidant properties and quality traits. Food Chemistry 357: 129791.
Guo C#, Wang Q#,Li Z, Sun J, Zhang Z, Li X*, Guo Y*(2021) Bioinformatics and expression analysis of IDA-Like genes reveal theirpotential functions in flower abscission and stress response in tobacco (Nicotiana tabacum L.). Frontiers in Genetics 12: 670794.
Wang Q#, Guo C#,Li Z, Sun J, Deng Z, Wen L, Li X*, GuoY* (2021) Potato NAC transcription factor StNAC053 enhances salt anddrought tolerance in transgenic Arabidopsis. International Journal of Molecular Sciences 22(5): 2568.
Zhang Z, Xu M and Guo Y* (2020) Ring/U-Box protein AtUSR1functions in promoting leaf senescence through JA signaling pathway inArabidopsis. Frontiers in Plant Science11: 608589.
Zhang Z, Liu C and Guo Y* (2020) Wheat transcriptionfactor TaSNAC11-4B positively regulates leaf senescence through promoting ROSproduction in transgenic Arabidopsis. InternationalJournal of Molecular Sciences 21(20): 7672.
Zhang Z, Li W, Gao X, Xu M and Guo Y* (2020) DEAR4, a member ofDREB/CBF family, positively regulates leaf senescence and response to multiplestressors in Arabidopsis thaliana. Frontiers in Plant Science 11: 367.
Gao X#, Wu X#,Liu G, Zhang Z, Chao J, Li Z, Guo Y*and Sun Y* (2019) Characterization and mapping of a novel premature leafsenescence mutant in common tobacco (Nicotianatabacum L.). Plants 8(10): 415.
Ahmad S and Guo Y*(2019) Signal transduction in leaf senescence: progress and perspective. Plants 8(10): 405.
Cao S, Zhang Z, Wang C, Li X, GuoC, Yang L and Guo Y* (2019)Identification of a novel melon transcription factor CmNAC60 as a potentialregulator of leaf senescence. Genes 10(8):584.
Li X#, Guo C#,Ahmad S, Wang Q, Yu J, Liu C and Guo Y*(2019) Systematic analysis of MYB family genes in potato and their multipleroles in development and stress responses. Biomolecules9(8): 317.
Li X#, Ahmad S#,Ali A, Guo C, Li H, Yu J, Zhang Y, Gao, X, GuoY* (2019) Characterization of Somatic Embryogenesis Receptor-Like Kinase 4as a negative regulator of leaf senescence in Arabidopsis. Cells 8(1):50.
Li W, Li X, Chao J, Zhang Z, WangW and Guo Y* (2018) NAC familytranscription factors in tobacco and their potential role in regulating leafsenescence. Frontiers in Plant Science9: 1900.
Li X#, Ahmad S#,Guo C, Yu J, Cao S, Gao X, Li W, Li H, GuoY* (2018) Identification and characterization of LRR-RLK family genes in potatoreveal their involvement in peptide signaling of cell fate decisions and biotic/abioticstress responses. Cells 7(9): 120.
Li X#, Hamyat M#,Liu C, Ahmad S, Gao X, Guo C, Wang Y*, GuoY* (2018) Identification and characterization of the WOX family genes infive Solanaceae species reveal their conserved roles in peptide signaling. Genes 9(5): 260.
Guo Y. (editor)(2018) Plant Senescence – Methods and Protocols, Humana Press, New York, NY, 367pages.
Li W, Guo Y* (2018) RNA-Seq analysis of the transcriptome of leaf senescencein tobacco. Methods in Molecular Biology 1744:331-337.
Zhang Z, Guo Y* (2018) Hormone treatments in studying leaf senescence. Methods in MolecularBiology 1744: 125-132.
Ali A, Gao X, Guo Y* (2018) Initiation, progression,and genetic manipulation of leaf senescence. Methods in Molecular Biology 1744: 9-31.
Li W, Zhang H, Li X, Zhang F, LiuC, Du Y, Gao X, Zhang Z, Zhang X, Hou Z, Zhou H, Sheng X, Wang G, Guo Y* (2017) Integrative metabolomicand transcriptomic analyses unveil nutrient remobilization events in leafsenescence of tobacco. Scientific Reports7(1): 12126.
Guo Y#, Flegel K#, Kumar J, McKay DJ, Buttitta LA* (2016) Ecdysone signaling induces two phasesof cell cycle exit in Drosophila cells. BiologyOpen, 5(11): 1648-1661.
Guo Y and Gan S* (2014) Translationalresearches on leaf senescence for enhancing plant productivity and quality. Journalof Experimental Botany 65 (14): 3901-3913.
Li W and Guo Y* (2014)Transcriptome, transcription factors and transcriptional regulation of leafsenescence. Journal of Bioinformatics andComparative Genomics, 1: 1-3.
Guo Y(2013) Towards systems biologicalunderstanding of leaf senescence. PlantMolecular Biology 82:519-528.
Gao X and Guo Y* (2012) CLE peptides in plants: proteolytic processing,structure-activity relationship, and ligand-receptor interaction. Journal of Integrative Plant Biology 54(10):738-45.
Guo Y and Gan S* (2012) Convergence and divergence in gene expressionprofiles induced by leaf senescence and 27 senescence-promoting hormonal,pathological and environmental stress treatments. Plant, Cell &Environment35(3):644-655.
Guo Y, Ni J, Denver R, Wang X and Clark SE* (2011) Mechanisms ofmolecular mimicry of plant CLE peptide ligands by the parasitic nematode Globodera rostochiensis. Plant Physiology 157(1):476-484.
Guo Y and Gan S* (2011) AtMYB2 regulates whole plant senescenceby inhibiting cytokinin-mediated branching at late stages of development in Arabidopsis. PlantPhysiology 156 (3): 1612-1619.
Ni J, Guo Y, Jin H,Hartsell J and Clark SE* (2011) Characterization of a CLE processing activity.Plant Molecular Biology 75(1-2): 67-75.
Guo Y, Han L, Hymes M, DenverRJ and Clark SE* (2010) CLAVATA2 forms a distinct CLE-binding receptor complexregulating Arabidopsis stem cell specification. Plant Journal 63(6): 889-900.
Guo Y and Clark SE* (2010)Membrane distributions of two ligand-binding receptor complexes in theCLAVATA pathway. Plant Signaling &Behavior 5(11): 1442-1445.
Zhou C, Cai Z, Guo Y andGan S* (2009) An Arabidopsis Mitogen-Activated Protein Kinase Cascade,MKK9-MPK6, Plays a Role in Leaf Senescence. PlantPhysiology 150: 167-77.
Stenvik GE, Tandstad NM, Guo Y, Shi CL, Kristiansen W, HolmgrenA, Clark SE, Aalen RB and Butenko MA* (2008) The EPIPpeptide of INFLORESCENCE DEFICIENTIN ABSCISSIONis sufficient to induce abscission in arabidopsis through the receptor-like kinasesHAESA and HAESA-LIKE2. Plant Cell20(7): 1805-17.
Guo Y and Gan S* (2007) Genetic manipulation of leaf senescence. In “Senescence Processes in Plants” (S. Gan,ed.), Blackwell Publishing, Oxford, UK, pp. 304-322.
Guo Y and Gan S* (2006) AtNAP, a NAC family transcription factor, has animportant role in leaf senescence. PlantJournal 46: 601-612.
Guo Y and Gan S* (2005) Leaf senescence: signals, execution, andregulation. Current Topics in DevelopmentalBiology 71: 83-112.
Guo Y#,Cai Z# and GanS* (2004) Transcriptome of Arabidopsis leaf senescence. Plant, Cell & Environment 27: 521-549.
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