团队组成：团队现有固定成员8人，包括首席科学家1人，一级骨干1人，二级骨干2人，助理4人；其中研究员4人，副研究员3人，博士后2人，在读博士研究生8名，硕士研究生15名。

主要研究方向：禽呼吸道病创新团队以严重危害养禽业的禽呼吸道病及其病毒为研究重点，立足于解决养禽业中禽呼吸道病疫病防控问题，系统研究病毒的生态分布、遗传变异规律、病毒的致病机理及疫苗的免疫机理等重点问题。

（1）禽呼吸道病流行病学研究

（2）病原致病机理、病原与宿主相作及免疫应答机制研究

（3）溶瘤病毒抗肿瘤作用机制及新型靶向药物研发

（4）新型禽呼吸道传染病疫苗及诊断制剂的创制

（5）基因工程载体活载体疫苗的研究

禽呼吸道病团队承担国家级和省部级项目25项：

1    黑龙江省自然科学基金团队项目 禽冠状病毒病分子流行病学与系列防控技术研究（申请编号JJ2021TD0024）刘胜旺100万2021-2023

2    黑龙江省自然科学基金杰青项目 鸡传染性喉气管炎病毒与宿主细胞代谢互作机制研究 李海 50万 2021-2023

3    黑龙江省自然科学基金重点项目 我国禽冠状病毒毒株资源体系建立及优势流行毒株免疫逃逸分子机制研究（ZD2019C006）韩宗玺 50万 2019-2022

4    国家科技支撑计划 禽流感等重要家禽疫病流行毒疫苗研究与开发（2015BAD12B03） 刘胜旺 690万 2015-2019

5    国家科技支撑计划 禽流感等重要禽病防控技术集成与示范（2015BAD12B05） 王云峰 117万 2015-2019

6    国家重点研发计划 坦布苏病毒体液免疫应答宿主决定机制研究（2016YFD0500107-4） 李海 127万 2016-2020

7    国家重点研发计划 畜禽重要疫病流行病学数据库和传播风险评估模型构建（2017YFD0500105） 李慧昕 330万 2017-2020

8    国家重点研发计划 水禽禽流感等重要疫病新型活载体疫苗研究（2017YFD0500805） 刘怀然 53万 2017-2020

9    国家重点研发计划 新城疫等综合防控研究及国际科技合作平台建设（2016YFE0203200） 张宇 45万 2017-2020

10  国家重点研发计划 商品蛋鸡高效安全饲养技术集成与示范（2018YFD0501302） 孙军峰 55万 2018-2020

11  国际合作项目 中埃禽传染病综合防控技术联合研究与技术示范应用（KY202002004） 韩宗玺 306万 2020-2022

12  国家自然科学基金面上项目 宿主p53抗鸡传染性喉气管炎病毒感染的分子机制研究（32072853） 李海 58万 2021-2024

13  国家自然科学基金面上项目 禽冠状病毒纤突蛋白在病毒跨种感染与致病进程中的分子作用机制研究（31872503） 韩宗玺 60万 2019-2022

14  国家自然科学基金面上项目 鸡干扰素诱导跨膜蛋白1抑制新城疫病毒感染的分子机制（31872504） 孙军峰 61万 2019-2022

15  国家自然科学基金青年基金 血清4型禽腺病毒3‘端135-bp自然缺失影响病毒致病性的研究（31702268） 李慧昕 24万 2018-2020

16  国家自然科学基金青年基金 鸡β-半乳糖凝集素蛋白-1在新城疫病毒感染中的作用及其分子机制（31502088） 孙军峰 24万 2016-2018

17  国家自然科学基金青年基金 禽网状内皮组织增生病病毒与宿主细胞波形蛋白相互作用机制的研究（31302092） 赵妍 25万2014-2016

18  农业行业科研专项 东北地区新城疫流行毒株抗原研究与应用 （201303033） 刘胜旺 106万 2013-2017

19  现代农业产业技术体系 蛋鸡产业疫病控制 （CARS-41-K12） 刘胜旺 280万 2013-2016

20  现代农业产业技术体系 蛋鸡产业疫病控制 （CARS-40-K18） 刘胜旺 253.75万 2017-2020

21  黑龙江省自然科学基金面上项目 鸡IFITM1对新城疫病毒在靶细胞复制的影响及其作用分子机制（C201461） 韩宗玺 6万 2014-2017

22  黑龙江省自然科学基金青年项目 膜联蛋白A2参与新城疫病毒复制和组装的作用机制（QC2015038） 孙军峰 5 2015-2018

23  黑龙江省自然科学基金面上项目 宿主p53对禽疱疹病毒I型诱导细胞凋亡过程的影响及其作用方式（LC2017016） 李海 5万 2017-2020

24  国家重点研发项目省级自助项目 禽流感等重要禽病防控技术集成与示范（GX16B003） 刘胜旺 25万 2016-2018

25  哈尔滨市人才项目 禽疱疹病毒I型宿主偏嗜性相关抗病毒靶标分子的筛选（2016RAXYJ072） 李海 10万 2015-2019

1、 黑龙江省自然科学基金团队项目： 禽冠状病毒病分子流行病学与系列防控技术研究（TD2021C001，2021-2023），100万元 ；

2、“十二五” 国家科技支撑计划项目：禽流感等重要家禽疫病流行毒疫苗研究与开发（2015BAD12B03，2015.04-2019.12）, 690万元；

3、 现代农业蛋鸡产业技术体系岗位科学家专项：鸡场生物安全与综合防控（CARS-40-K18，2016.01-2020.12），350万元；

4、禽呼吸道病创新团队创新经费项目，2017.01-2019.12，660万元；

5、科研院所基本科研业务费、兽医生物技术国家重点实验室专项等其他项目，2017年经费140余万元。

  一、代表论文与著作

1          Ran Zhao, Qiankai Shi, Zongxi Han, Zhen Fan, Hui Ai, Linna Chen, Le Li,Tianyi Liu, Junfeng Sun, Shengwang Liu. Newcastle Disease Virus Entry intoChicken Macrophages via a pH-Dependent, Dynamin and Caveola-Mediated EndocyticPathway That Requires Rab5. Journal of Virology. 2021, 95:e02288-20

2          Zongxi Han, Xiaochen Xu, Huixin Li, Lili Zhang, Yutong Hou, ShengwangLiu. Replication and vaccine protection of multiple infectious bronchitis virusstrains in pheasants (Phasianus colchicus). Infection, Genetics and Evolution.2021,93:104

3          Zhitao Wang, Yangyang Qiao, Zhijie Chen, Yumeng Liang, Lu Cui, YanhuiZhang, Xuefeng Li, Li Xu, Ping Wei, Shengwang Liu, Hai Li. Fos FacilitatesGallid Alpha-Herpesvirus 1 Infection by Transcriptional Control of HostMetabolic Genes and Viral Immediate Early Gene. Viruses. 2021, 13(6):1110

4          Lu Cui, Yong Ma, Yumeng Liang, Yanhui Zhang, Zhijie Chen, Zhitao Wang, HanguangWu, Xuefeng Li, Li Xu, Shengwang Liu, Hai Li. Polarization of avian macrophagesupon avian flavivirus infection. Veterinary Microbiology. 2021, 256:109044

5          Yangyang Qiao, Zhitao Wang, Zongxi Han, YuhaoShao, Yong Ma, Yumeng Liang, Zhijie Chen, Hanguang Wu, Lu Cui, Yanhui Zhang,Shengwang Liu, Hai Li. Global exploration of the metabolic requirements of gallidalphaherpesvirus 1. PLoS Pathogens. 2020,16(8): e1008

6          Zongxi Han, Xu Liwen, Mengting Ren, Jie Sheng,Tianxin Ma, Junfeng Sun, Yan Zhao, Shengwang Liu. Genetic, antigenic andpathogenic characterization of avian coronaviruses isolated from pheasants(Phasianus colchicus) in China. Veterinary Microbiology. 2020,240: 108513

7          Mengting Ren, Zongxi Han, Yan Zhao, JunfengSun, Shengwang Liu, Deying Ma. Multiple recombination events between field andvaccine strains resulted in the emergence of a novel infectious bronchitisvirus with decreased pathogenicity and altered replication capacity. PoultryScience.2020，99:1928–1938

8          Mengting Ren, Lili Zhang, Yutong Hou, Yan Zhao,Zongxi Han, Junfeng Sun, Shengwang Liu. Genetic, Antigenic, and PathogenicCharacteristics of Infectious Bronchitis Virus GI-7/TW-II in China. AvianDiseases. 2020, 64(2):183-196

9          Jie Sheng, Mengting Ren, Zongxi Han, JunfengSun, Yan Zhao, Shengwang Liu. Genetic and antigenic heterogeneity ofGI-1/Massachusetts lineage infectious bronchitis virus variants recentlyisolated in China. Poultry Science. 2020, 99:5440–5451

10      Yutong Hou, Lili Zhang, Mengting Ren, ZongxiHan, Junfeng Sun, Yan Zhao, Shengwang Liu. A highly pathogenic GI-19 lineageinfectious bronchitis virus originated from multiple recombination events withbroad tissue tropism. Virus Research. 2020, 285:19

11      Xiao Wei, Yuhao Shao, Zongxi Han, Junfeng Sun,Shengwang Liu. Glycoprotein-C-gene-deleted recombinant infectiouslaryngotracheitis virus expressing a genotype VII Newcastle disease virusfusion protein protects against virulent infectious laryngotracheitis virus andNewcastle disease virus. Veterinary Microbiology. 2020, 250: 1088

12      Junfeng Sun, Zongxi Han, Ran Zhao, Hui Ai,Linna Chen, Le Li, Shengwang Liu. Protection of chicks from Newcastle diseaseby combined vaccination with a plasmid DNA and the pre-fusion protein of thevirulent genotype VII of Newcastle disease virus. Vaccine.2020, 38:7337–7349

13      Wenjun Zhao, Xuefeng Li, Huixin Li, Zongxi Han,Fangfang Wang, Chenggang Liu, Yuhao Shao, Deying Ma. Fowl adenoviruse-4infection induces strong innate immune responses in chicken. ComparativeImmunology, Microbiology and Infectious Diseases. 2020, 68:101404

14      Yong Ma, Yumeng Liang, Nana Wang, Lu Cui,Zhijie Chen, Hanguang Wu, Chenyang Zhu, Zhitao Wang, Shengwang Liu, Hai Li. AvianFlavivirus Infection of Monocytes/Macrophages by Extensive Subversion of HostAntiviral Innate Immune Responses. Journal of Virology. 2019, 93:e00978-19

15      Mengting Ren, Jie Sheng, Tianxin Ma, Liwen Xu,Zongxi Han, Huixin Li, Yan Zhao, Junfeng Sun, Shengwang Liu. Molecular andbiological characteristics of the infectious bronchitis virus TC07-2/GVI-1lineage isolated in China. Infection, Genetics and Evolution. 2019, 75: 103942.

16      Tianxin Ma, Liwen Xu, Mengting Ren, Jie Shen,Zongxi Han, Junfeng Sun, Yan Zhao, Shengwang Liu. Novel genotype of infectiousbronchitis virus isolated in China. Veterinary Microbiology. 2019, 230, 178–186

17      Liwen Xu, Mengting Ren, Jie Sheng, Tianxin Ma,Zongxi Han, Yan Zhao, Junfeng Sun, Shengwang Liu. Genetic and biologicalcharacteristics of four novel recombinant avian infectious bronchitis virusesisolated in China. Virus Research. 2019, 263, 87–97

18      Zhitao Wang, Bangyao Sun, Qi Gao, Yong Ma,Yumeng Liang, Zhijie Chen, Hanguang Wu, Lu Cui, Yuhao Shao, Ping Wei, Hai Li,Shengwang Liu. Host Src controls gallid alpha herpesvirus 1 intercellularspread in a cellular fatty acid metabolism-dependent manner. Virology. 2019,537:1-13

19      Hai Li, Qi Gao, Yuhao Shao, Bangyao Sun,Fengjie Wang, Yangyang Qiao, Nana Wang, Shengwang Liu. Gallid Herpesvirus 1Initiates Apoptosis in Uninfected Cells through Paracrine Repression of p53.Journal of Virology. 2018, 92(18). JVI.00529-18

20      Chenggang Liu, Lei Jiang, Liangliang Liu, LiSun, Wenjun Zhao, Yuqiu Chen, Tianming Qi, Zongxi Han, Yuhao Shao, ShengwangLiu, Deying Ma. Induction of Avian β-Defensin 2 Is Possibly Mediated by the p38MAPK Signal Pathway in Chicken Embryo Fibroblasts After Newcastle Disease VirusInfection. Frontiers in Microbiology. 2018, 9:751

21      Zongxi Han, Lei Jiang, Wenjun Zhao, Yuqiu Chen,Liwen Xu, Junfeng Sun, Yan Zhao, Shengwang Liu. Isolation and Characteristicsof the Arkansas-Type Infectious Bronchitis Virus in China. Avian Diseases.2018, 62(1):18-27

22      Dan Shan, Shouguo Fang, Zongxi Han, Hui Ai,Wenjun Zhao, Yuqiu Chen, Lei Jiang, Shengwang Liu. Effects of hypervariableregions in spike protein on pathogenicity, tropism, and serotypes of infectiousbronchitis virus. Virus Research. 2018, 250:104–113

23      Liwen Xu, Zongxi Han, Lei Jiang, Junfeng Sun,Yan Zhao, Shengwang Liu. Genetic diversity of avian infectious bronchitis virusin China in recent years. Infection, Genetics and Evolution. 2018, 66:82-94

24      Zongxi Han, Mengying Gao, Yuqiu Chen, WenzhuoZhao, Junfeng Sun, Yan Zhao, Shengwang Liu. Genetics, antigenicity andvirulence properties of three infectious bronchitis viruses isolated from asingle tracheal sample in a chicken with respiratory problems. Virus Research.2018,257:82–93

25      Tingting Zhang, Mengting Ren, Chenggang Liu,Liwen Xu, Fangfang Wang, Zongxi Han, Yuhao Shao, Deying Ma. Comparativeanalysis of early immune responses induced by two strains of Newcastle diseasevirus in chickens. MicrobiologyOpen. 2018;e701

26      Yuhao Shao, Junfeng Sun, Zongxi Han, ShengwangLiu. Recombinant infectious laryngotracheitis virus expressing Newcastledisease virus F protein protects chickens against infectious laryngotracheitisvirus and Newcastle disease virus challenge. Vaccine. 2018, 36(52) 7975-86

27      Lei Jiang,Zongxi Han, Yuqiu Chen, Wenjun Zhao, Junfeng Sun, Yan Zhao， ShengwangLiu*.Characterization of the complete genome, antigenicity, pathogenicity,tissue tropism, and shedding of a recombinant avian infectious bronchitis viruswith a ck/CH/LJL/140901-like backbone and an S2 fragment from a 4/91-likevirus. Virus Research, 2018, 244:99-109

28      JunfengSun, Zongxi Han, Tianming Qi, Ran Zhao, Shengwang Liu*.Chicken galectin-1Binhibits Newcastle disease virus adsorption and replication through binding toHN glycoprotein.Journal of Biological Chemistry, 2017, 292(49):20141-61

29      Lei Jiang,Wenjun Zhao, Zongxi Han, Yuqiu Chen, Yan Zhao, Junfeng Sun, Huixin Li, YuhaoShao,Liangliang Liu, Shengwang Liu*.Genome characterization, antigenicity andpathogenicity of a novel infectious bronchitis virus type isolated from southChina.Infection, Genetics and Evolution, 2017,54: 437–446

30      Yu Zhang,Chenyang Zhua, Bangyao Sun, Jiawei Lv, Zhonghua Liu, Shengwang Liu*, Hai Li*,Integrated High Throughput Analysis Identifies GSK3 as a Crucial Determinant ofp53-Mediated Apoptosis in Lung Cancer Cells.Cellular Physiology andBiochemistry,2017;42:1177-1191

31      Ran Zhao,Junfeng Sun, Tianmin Qi, Wen Zhao, Zongxi Han, Xiaopu Yang,Shengwang Liu*.Recombinant Newcastle disease virus expressing the infectious bronchitis virusS1 gene protects chickens against Newcastle disease virus and infectiousbronchitis virus challenge. Vaccine. 2017,35(18):2435-2442

32      QianqianXu, Junfeng Sun, Mengying Gao, Shasha Zhao, Huairan Liu, TingTing Zhang, ZongxiHan, Xiangang Kong, Shengwang Liu*.Journal of Veterinary DiagnosticInvestigation,2017,29(4):489-498

33      Zongxi Han,Wenjun Zhao, Yuqiu Chen, Qianqian Xu, Junfeng Sun, Tingting Zhang,Yan Zhao,Shuling Liang, Mengying Gao, Qiuling Wang, Xiangang Kong, Shengwang Liu*.Genetic, antigenic, and pathogenic characteristics of avian infectiousbronchitis viruses genotypically related to 793/B in China. VeterinaryMicrobiology, 2017,203:125–135

34      WenjunZhao, Mengying Gao, Qianqian Xu, Yang Xu, Yan Zhao, Yuqiu Chen,Tingting Zhang,Qiuling Wang, Zongxi Han, Huixin Li, Lingfeng Chen, Shuling Liang,Yuhao Shao,Shengwang Liu*. Origin and evolution of LX4 genotype infectious bronchitiscoronavirus in China. Veterinary Microbiology,2017(198):9–16.

35      Yuqiu Chen,Lei Jiang, Wenjun Zhao, Liangliang Liu, Yan Zhao, Yuhao Shao, Huixin Li, ZongxiHan, Shengwang Liu*. Identification and molecular characterization of a novelserotype infectious bronchitis virus (GI-28) in China. VeterinaryMicrobiology,2017(198):108–115.

36      Zongxi Han,Tingting Zhang, Qianqian Xu, Mengying Gao, Yuqiu Chen, Qiuling Wang, Yan Zhao,Yuhao Shao, Huixin Li, Xiangang Kong, Shengwang Liu*, Altered pathogenicity ofa tl/CH/LDT3/03 genotype infectious bronchitis coronavirus due to naturalrecombination in the 5′- 17 kb region of the genome. Virus Research，2016，213：140–148

37      QianqianXu, Zongxi Han, Qiuling Wang, Tingting Zhang, Mengying Gao, Yan Zhao, YuhaoShao, Huixin Li, Xiangang Kong, Shengwang Liu*. Emergence of novelnephropathogenic infectious bronchitis viruses currently circulating in Chinesechicken flocks. Avian Pathology, 2016,45:1, 54-65.

38      Huixin Li,JuanWang, Liye Qiu, Zongxi Han, Shengwang Liu*. Fowl adenovirus species Cserotype 4 is attributed to the emergence of hepatitis-hydropericardiumsyndrome in chickens in China. Infection, Genetics and Evolution,2016,45:230–241.

39      QianqianXu, Yuqiu Chen, Wenjun Zhao, Tingting Zhang, Chenggang Liu, Tianming Qi, ZongxiHan, Yuhao Shao, Deying Ma ,Shengwang Liu*. Infection of Goose with GenotypeVIId Newcastle Disease Virus of Goose Origin Elicits Strong Immune Responses atEarly Stage. Frontiers in Microbiology. 2016, 7:1587.

40      Huixin Li,Yulong Wang, Zongxi Han, Yu Wang , Shulin Liang, Lu Jiang, Yonghao Hu, XiangangKong, Shengwang Liu*. Recombinant duck enteritis viruses expressing majorstructural proteins of the infectious bronchitis virus provide protectionagainst infectious bronchitis in chickens. Antiviral Research. 2016, 130:19e26.

41      MengyingGao, Qiuling Wang, Wenjun Zhao, Yuqiu Chen, Tingting Zhang, Zongxi Han,QianqianXu, Xiangang Kong, Shengwang Liu*. Serotype, antigenicity, and pathogenicity ofa naturally recombinant TW I genotype infectious bronchitis coronavirus inChina. Veterinary Microbiology,2016,191:1–8.

  二、专利和标准

1. 1、 刘胜旺，孔宪刚，韩宗玺，邵昱昊，李慧昕，鸡传染性支气管炎病毒弱毒疫苗株及其应用，2011.03.23，中国，ZL200910128488.5
2.  2、刘胜旺，韩宗玺，邵昱昊，刘晓丽，孔宪刚，鸡传染性支气管炎冷适应致弱疫苗株及其应用，2013.03.20，中国，ZL201110110461.0
3. 3、 刘胜旺，李慧昕，韩宗玺，孔宪刚，表达增强型绿色荧光蛋白基因的鸭瘟病毒重组疫苗株及其构建方法和应用，2017.01.18，中国，ZL201410330828.3
4. 4、 刘胜旺，李慧昕，韩宗玺，王娟，邵昱昊，产蛋下降综合征诊断技术，NY/T 551-2017
5. 5、鸡传染性支气管炎致弱疫苗株LDL-T株及其应用（ZL201710308221.9），2018年5月
6. 6、一种表达新城疫病毒F蛋白的传染性喉气管炎重组病毒株及其构建方法和应用（ZL201810420386.X），2019年5月
7. 7、一种鸡Nrf2蛋白抗体及其免疫原、免疫原性多肽、检测试剂盒和应用（ZL201910184841.5），2019年11月
8. 8、一种鸡Nrf2蛋白抗体及其免疫原、免疫原性多肽、ELISA检测试剂盒和应用（ZL201910184817.1），2019年11月
9. 9、一种形成新城疫病毒F蛋白融合前构象的多肽、核苷酸及构建方法和应用（ZL201910819317.0）2020年6月

 三、获得奖励

1. 1、 中国鸡传染性支气管病毒流行、变异机制及毒株资源库的建立，黑龙江省自然科学奖一等奖，刘胜旺，韩宗玺，邵昱昊，刘晓丽，孔宪刚，2015年
2. 2、 新型禽用疫苗与诊断试剂研究团队奖，中华农业科技奖，优秀创新团队奖（等同于科研成果一等奖），王笑梅，刘胜旺，王云峰，刘长军，高玉龙，祁小乐，秦立廷，高宏雷，韩宗玺，邵昱昊，刘晓丽，李慧昕，张艳萍，李志杰，崔红玉，赵妍，王永强，2013年
   
3. 3、中国专利优秀奖 鸡传染性支气管病毒弱毒疫苗株及其应用，刘胜旺，孔宪刚，韩宗玺，邵昱昊，李慧昕，2018年12月
4. 四、新兽药证书
   
5. 1、鸡传染性支气管炎活疫苗（LDT3-A株），2011新兽药证字（51）号
   
6. 2、鸡新城疫、传染性支气管炎二联活疫苗（LaSota株+LDT3-A株）2019新兽药证字（35号）
7. 3、鸡传染性支气管炎ELISA抗体检测试剂盒（2018）新兽药证字44号