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李习龙，男，博士，研究员，博士生导师。2003年本科毕业于华中农业大学，2006年硕士毕业于中国农业大学，2011年博士毕业于美国Texas A&MUniversity。博士毕业后进入美国Baylor college of Medicine进行博士后研究工作。2015年以青年英才计划被中国农业科学院饲料研究所引进。现为猪营养与饲料创新团队首席科学家。
长期从事猪营养与饲料科学方面研究。目前已在国际杂志上发表30多篇论文，其中以第一和通讯作者在Nat. Commun.、J. Anim. Sci.Biotechnol.等杂志上发表SCI文章10多篇。主持和参与国家自然基金项目、“十三五”国家重点研发计划、国家重点研发计划中美政府间合作项目、北京市自然基金项目、中国农科院创新工程项目等多个项目。担任国际期刊Amino Acids杂志Editorialboard，同时为多个国际期刊审稿人。
研究方向主要为：1）母猪繁殖性能的营养调控，为母猪妊娠早期胎儿死亡率高、繁殖性能低下提供新的解决方案；2）植物活性成分调控仔猪肠道健康作用及其机制；3）猪饲料原料营养价值评定与营养需要量研究。
1.主持国家自然科学基金，腐胺调控仔猪肠黏膜上皮细胞增殖和损伤修复的分子机制，2017.1-2018.12，25万元；
2.主持国家重点研发计划子课题，功能性添加剂促进母猪泌乳性能的研究，2018.7-2021.6，26万元；
3.主持河北省重点研发项目，发酵亚麻籽饼粕应用于生猪饲料的提质增效技术创制，2021.6-2023.12，50万元;
4.参与北京市自然科学基金，3,4,5-三羟基苯甲酸调控断奶仔猪肠黏膜中NF-кB通路的分子机制，2017.1-2018.12，10万元；
5.参与国家重点研发计划中美政府间合作项目，植物提取物作用于DNA核苷酸切除修复机理研究，2019.11-2022.10，249万元。
CaiL, Wei Z X, Zhao X M, Li Y P, Li X L, Jiang X R*. Gallic acidmitigates LPS-induced inflammatory response via suppressing NF-κB signalingpathway in IPEC-J2 cells. Journal of Animal Physiology and Animal Nutrition,2021. doi: 10.1111/jpn.13612.
张彦利 蒋显仁 李习龙. 饲粮高剂量氧化锌及其替代物在断奶仔猪中的研究进展. 动物营养学报.2021,33(3):1257-1265.
Y. P. Li ,X. R. Jiang, Z. X. Wei, L. Cai, J. D. Yin and X. L. Li. Effects of soybean isoflavoneson the growth performance, intestinal morphology and antioxidative propertiesin pigs. Animal. 2020. 14:2262-2270. doi:10.1017/S1751731120001123.
L.Cai Y.P.LiZ.X.Wei X.L.Li X.R.Jiang. Effects of dietary gallic acid on growth performance,diarrhea incidence, intestinal morphology, plasma antioxidant indices, andimmune response in weaned piglets. Animal Feed Science and Technology. 2020.261:114391.
蔡龙，李习龙，蒋显仁. 没食子酸的生物学功能及在畜禽生产中的应用. 动物营养学报.2019,31(1):102-108.
Liu B, JiangX, Cai L, Zhao X, Dai Z, Wu G, Li X. Putrescine mitigates intestinal atrophythrough suppressing inflammatory response in weanling piglets. J Anim SciBiotechnol. 2019;10:69.
WangX, Li X*, WangT, Wu SP, JeongJW, KimTH, YoungSL, LesseyBA, LanzRB, LydonJP, DeMayoFJ. SOX17 regulates uterine epithelial-stromalcross-talk acting via a distal enhancer upstream of Ihh. Nat Commun. 2018;9:4421. (*equal contribution as first author)
Liu B, Lü H, Jiang X, Li X. Effect of Astragalus polysaccharidesupplementation on growth performance and plasma parameters of weaned pigletsunder commercial condition. Int. J. of Health, Animal science and Food safety.2018;5: 50-59.
Hou Y, LiX, Dai Z, Wu Z, Bazer FW, Wu G. Analysis of Glutathione in BiologicalSamples by HPLC Involving Pre-Column Derivatization with o-Phthalaldehyde.Methods Mol Biol. 2018;1694:105-115.
Jiang X, Li X, Awati A, Bento H, ZhangH and Bontempo V. Effect of an essential oils blend on growth performance, andselected parameters of oxidative stress and antioxidant defence of Escherichiacoli challenged piglets. J. Anim. Feed Sci. 2017. 26, 38-43.
Steinhauser CB, Wing TT, Gao H, Li X, Burghardt RC, Wu G, Bazer FW,Johnson GA.
Identification of appropriate referencegenes for qPCR analyses of placental expression of SLC7A3 and induction ofSLC5A1 in porcine endometrium. Placenta. 2017:52:1-9.
Mazur EC, Vasquez YM, Li X, KommaganiR, Jiang L, Chen R, Lanz RB, Kovanci E, Gibbons WE, DeMayo FJ. 2015.Progesterone receptor transcriptome and cistrome in decidualized humanendometrial stromal cells. Endocrinology. 2015;156:2239-53.
Vasquez YM,Mazur EC, Li X, Kommagani R, Jiang L, Chen R, Lanz RB, Kovanci E, Gibbons WE,DeMayo FJ. FOXO1 is required for binding of PR on IRF4, novel transcriptionalregulator of endometrial stromal decidualization. Mol Endocrinol. 2015Mar;29(3):421-33.
Li X, BazerFW, Johnson GA, Burghardt RC, Frank JW, Dai Z, Wang J, Wu Z, Shinzato I, Wu G.Dietary supplementation with L-arginine between days 14 and 25 of gestationenhances embryonic development and survival in gilts. Amino Acids.2014;46:375-84.
Li X, LargeMJ, Creighton CJ, Lanz RB, Jeong JW, Young SL, Lessey BA, Palomino WA, Tsai SY,Demayo FJ. COUP-TFII regulates human endometrial stromal genes involved ininflammation. Mol Endocrinol. 2013;27:2041-54.
Wu G, Bazer FW, Satterfield MC, Li X, Wang X, Johnson GA, Burghardt RC, Dai Z, Wang J, Wu Z. Impacts of arginine nutrition on embryonic and fetal development inmammals. Amino Acids. 2013;45:241-56.
LeiJ, Feng D, Zhang Y, Dahanayaka S, Li X, Yao K, Wang J, Wu Z, Dai Z, Wu G.Hormonal regulation of leucine catabolism in mammary epithelial cells.AminoAcids. 2013;45:531-41.
WuG, Bazer FW, Johnson GA, Burghardt RC, LiX, Dai Z, Wang J, Wu Z. 2013. Maternal and fetal amino acid metabolism ingestating sows. SocReprodFertil Suppl. 2013;68:185-98.
DaiZ, Li X, Xi P, Zhang J, Wu G, Zhu W.2013. L-Glutamine regulates amino acid utilization by intestinal bacteria. AminoAcids.2013; 45:501-12.
Lei J, Feng D, Zhang Y, Dahanayaka S, Li X, Yao K, Wang J, Wu Z, Dai Z, Wu G.Regulation of leucine catabolism by metabolic fuels in mammary epithelialcells.Amino Acids. 2012;43:2179-89.
Go G, Wu G, Silvey DT, Choi S, Li X, Smith SB. Lipidmetabolism in pigs fed supplemental conjugated linoleic acid and/or dietaryarginine. Amino Acids. 2012;43:1713-26.
DaiZ, Li X, Xi P, Zhang J, Wu G, Zhu W.Regulatory role for L-arginine in the utilization of amino acids by pigsmall-intestinal bacteria. Amino Acids.2012; 43:233-44.
Gao H, Sathishkumar KR, Yallampalli U, Balakrishnan M, Li X, Wu G, Yallampalli C.Maternal protein restriction regulates IGF2 system in placental labyrinth. Front Biosci (Elite Ed). 2012;4:1434-50.
DaiZ, Li X, Xi P, Zhang J, Wu G, Zhu W.Metabolism of select amino acids in bacteria from the pig small intestine. Amino Acids.2012; 42:1597-608.
KongX, Tan B, Yin Y, Gao H, Li X, JaegerLA, BazerFW, Wu G. L-arginine stimulates the mTOR signalingpathway and protein synthesis in porcine trophectoderm cells. J Nutr Biochem. 2012;23:1178-83.
Xi P, JiangZ, Dai Z, Li X, Yao K, ZhengC, Lin Y, WangJ, Wu G. Regulation of protein turnover byL-glutamine in porcine intestinal epithelial cells.J NutrBiochem. 2012;23:1012-7.
Yao K, Yin Y, Li X, Xi P, WangJ, Lei J, Hou Y, Wu G. Alpha-ketoglutarate inhibits glutaminedegradation and enhances protein synthesis in intestinal porcine epithelialcells. AminoAcids. 2012;42:2491-500.
Li X, Rezaei R, Li P, Wu G. (2011) Composition of amino acids in feedingredients for animal diets. Amino Acids. 40:1159-68.
Wu G, Bazer FW, Johnson GA, Knabe DA, Burghardt RC,Spencer TE, Li X, Wang JJ. (2011)Triennial Growth Symposium: important roles for L-glutamine in swine nutritionand production. J Anim Sci.89:2017-30.
WuG, Bazer FW, Burghardt RC, Johnson GA, Kim SW, Knabe DA, Li P, Li X,McKnight JR, Satterfield MC, Spencer TE. Proline and hydroxyproline metabolism:implications for animal and human nutrition. Amino Acids.2011;40:1053-63.
McKnightJR, Satterfield MC, Li X, Gao H, Wang J, Li D, Wu G. Obesity inpregnancy: problems and potential solutions. Front Biosci (Elite Ed).2011;3:442-52.
Li X, Bazer FW, Johnson GA, Burghardt RC, Erikson DW,Frank JW, Spencer TE, Shinzato I, and Wu G. Dietary Supplementation with 0.8%L-Arginine between Days 0 and 25 of Gestation Reduces Litter Size in Gilts. J.Nutr.2010;140:1111-16.
SatterfieldMC, Gao H, Li X, Wu G, Johnson GA,Spencer TE, Bazer FW. Select nutrients and their associated transporters areincreased in the ovine uterus following early progesterone administration. BiolReprod.2010; 82:224-31.
Yin J, Li X, Li D, Yue T, Fang Q, Ni J, ZhouX, Wu G. Dietary supplementation with zinc oxide stimulates ghrelin secretionfrom the stomach of young pigs. J Nutr Biochem. 2009;20:783-90.
ChenL, Li P, Wang J, Li X, Gao H, Yin Y, Hou Y, Wu G. Catabolism ofnutritionally essential amino acids in developing porcine enterocytes. Amino Acids. 2009;37:143-52.
Li P, Kim SW, Li X, Datta S, Pond WG, Wu G. Dietary supplementation with cholesterol anddocosahexaenoic acid affects concentrations of amino acids in tissues of youngpigs. Amino Acids.2009;37:709-16.
Li X, Bazer FW, Gao H, Jobgen W, Johnson GA, Li P,McKnight JR, Satterfield MC, Spencer TE, Wu G. (2009) Amino acids and gaseous signaling. Amino Acids. 37:65-78.
LassalaA, Bazer FW, Cudd TA, Li P, Li X,Satterfield MC, Spencer TE, Wu G.Intravenous administration of L-citrulline to pregnant ewes is more effectivethan L-arginine for increasing arginine availability in the fetus. JNutr.2009; 139:660-5.
HaynesTE, Li P, Li X, Shimotori K, Sato H,Flynn NE, Wang J, Knabe DA, Wu G.L-Glutamine or L-alanyl-L-glutamine prevents oxidant- or endotoxin-induceddeath of neonatal enterocytes. Amino Acids.2009; 37:131-42.
Gao H, WuG, Spencer TE, Johnson GA, Li X,Bazer FW. (2009) Select nutrients inthe ovine uterine lumen. I. Amino acids, glucose, and ions in uterine lumenalflushingsof cyclic and pregnant ewes. Biol Reprod. 80:86-93.
Wu G,Bazer FW, Burghardt RC, Johnson GA, Kim SW, Li X, Satterfield MC, Spencer TE. (2009) Impacts of amino acidnutrition on pregnancy outcome in pigs: mechanisms and implications for swineproduction. J Anim Sci. 88(13 Suppl):E195-204.
Li P, KimSW, Li X, Datta S, Pond WG, Wu G.Dietary supplementation with cholesterol and docosahexaenoic acid increases theactivity of the arginine-nitric oxide pathway in tissues of young pigs. NitricOxide. 2008;19:259-65.
Wang J, Chen L, Li P, LiX, Zhou H, Wang F, Li D, Yin Y, Wu G. (2008) Gene expression is altered inpiglet small intestine by weaning and dietary glutamine supplementation. JNutr. 138:1025-32.
Li X, Yin J,Li D, Chen X, Zang J, Zhou X. Dietary supplementation with zinc oxide increasesIgf-I and Igf-I receptor gene expression in the small intestine of weanlingpiglets. J Nutr.2006; 136:1786-91.
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